The atypical profile of quetiapine is supported by its lack of sustained elevation of plasma prolactin concentrations
May 18-20, San Diego, Calif. Abstract NR232
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Multiple fixed doses of Seroquel (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo
Arvanitis LA, Miller BG, and the Seroquel Trial 13 Study Group. Multiple fixed doses of Seroquel (quetiapine) in patients with acute exacerbation of schizophrenia: a comparison with haloperidol and placebo. Biol Psychiatry 1997;42:233-2-6
Efficacy and extrapyramidal side effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: A meta-analysis of randomized controlled trials
Leucht S, Pitschel-Walz G, Abraham D, et al. Efficacy and extrapyramidal side effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials. Schizophr Res 1999;35: 51-68
ICI 204,636 (Seroquel): A dibenzothiazepine atypical antipsychotic: review of preclinical pharmacology and highlights of Phase II clinical trials
Goldstein JM, Arvanitis LA. ICI 204,636 (Seroquel): a dibenzothiazepine atypical antipsychotic: review of preclinical pharmacology and highlights of Phase II clinical trials. CNS Drug Review 1995;1:50-73
Multiple-dose pharmacokinetics of 'Seroquel' (quetiapine) in elderly psychotic patients
Wong J, Ewing BJ, Jaskiw G, et al. Multiple-dose pharmacokinetics of 'Seroquel' (quetiapine) in elderly psychotic patients [abstract]. Schizophr Res 1997;24:199-200
Quetiapine in patients with schizophrenia: A high- and low-dose double-blind comparison with placebo
Small JG, Hirsch SR, Arvanitis LA, et al. Quetiapine in patients with schizophrenia: a high- and low-dose double-blind comparison with placebo. Arch Gen Psychiatry 1997;54:549-557
ICI 204,636, an atypical antipsychotic: Efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia
U.S. Seroquel Study Group
Borison RL, Arvanitis LA, Miller BG. ICI 204,636, an atypical antipsychotic: efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia. U.S. Seroquel Study Group. J Clin Psychopharmacol 1996;16:158-169
N-[11C]methylspiperone PET. In contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic
Hagberg G, Gefvert O, Bergstrom M, et al. N-[11C]methylspiperone PET. in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic. Psychiatry Res 1998;30:147-160
Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia
Berl
Gefvert O, Bergstrom M, Langstrom B, et al. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology (Berl) 1998;135:119-126
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors
Seeman P, Corbett R, Van Tol HH. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 1997;16:93-110