In vivo dynamic real-time monitoring and quantification of platelet- thrombus formation: Use of a local isotope detector

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 3, 2000, Pages 860-865

  Zaman, Azfar G ^a   Osende, Julio I ^a   Chesebro, James H ^a   Fuster, Valentin ^a   Padurean, Adrian ^b   Gallo, Richard ^c   Worthley, Stephen G ^a   Helft, Gerard ^a   Rodriguez, Oswaldo X ^a   Fallon, John T ^a   Badimon, Juan J ^a,d  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b REGIONS HOSPITAL   (United States)

^c MONTREAL HEART INSTITUTE   (Canada)

^d Cardiovasc Biol Res Laboratory   (United States)

Author keywords

Antithrombotics; Platelets; Radioisotopes; Thrombus

Indexed keywords

ACETYLSALICYLIC ACID; HEPARIN; HIRUDIN; INDIUM 111;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY FLOW; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; DOPPLER FLOWMETRY; IMAGE ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SCINTIANGIOGRAPHY; SWINE; THROMBOCYTE AGGREGATION; THROMBOGENESIS; VALIDATION PROCESS;

EID: 0034101444     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.3.860     Document Type: Article

References (22)

1. Steele PS, Chesebro JH, Stanson AW, Holmes DR, Dewanjee MK, Badimon L, Fuster V. Balloon angioplasty: natural history of the pathophysiological response to injury in a pig model. Circ Res. 1985;57: 105-122.
2. Fuster V, Falk E, Fallon JT, Badimon L, Chesebro JH, Badimon JJ. The three processes leading to post PTCA restenosis: dependence on the lesion substrate. Thromb Haemost. 1995;74:552-559.
3. Eisen WG, van Reyn J, Birk G, Hoffman B, Schlachetzki F, Kubale R, Schneider E, Hoffman U. Noninvasive method for measuring thrombus formation in patients after peripheral angioplasty using three-dimensional B-mode and color-coded Doppler ultrasonography. J Clin Pharmacol. 1997;37:79S-83S.
4. Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest. 1993;92:2003-2012.
5. Diquelou A, Lemozy S, Depoy D, Boneu B, Sakariassen KS, Cadroy Y. Effect of blood flow on thrombin generation is dependent on the nature of the nature of the thrombogenic surface. Blood. 1994;84:2206-2213.
6. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996;348:1329-1339.
7. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation. 1994;90:1631-1637.
8. Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study Investigators. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. N Engl J Med. 1998;338: 1498-1505.
9. Folts J. An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombus. Circulation. 1991;83(suppl IV):IV-3-IV-14.
10. Wysokinski WE, McBane RD, Owen WG. Individual propensity for arterial thrombosis. Arterioscler Thromb Vasc Biol. 1999;19:883-886.
11. McBane RD, Wysokinski WE, Chesebro JH, Owen WG. Antithrombotic action of endogenous porcine protein C activated with a latent porcine thrombin preparation. Thromb Haemost. 1995;74:879-885.
12. McBane RD Miller RS, Hassinger NL, Chesebro JH, Nemerson Y, Owen WG. Tissue prothrombin: universal distribution in smooth muscle. Arterioscler Thromb Vasc Biol. 1997;17:2430-2437.
13. Wysokinski W, McBane R, Chesebro JH, Owen WG. Reversibility of platelet thrombosis in vivo: quantitative analysis in porcine carotid arteries. Thromb Haemost. 1996;76:1108-1113.
14. Badimon L, Badimon JJ, Galvez A, Chesebro JH, Fuster V. Influence of arterial damage and wall shear rate on platelet deposition: ex vivo study in a swine model. Arteriosclerosis. 1986;6:312-320.
15. Folts JD, Gallagher KP, Rowe GG. Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? Circulation. 1982;65:248-255.
16. Sakariassen KS, Kuhn H, Muggli R, Baumgartner HR. Growth and stability of thrombi in flowing citrated blood: assessment of platelet-surface interactions with computer-assisted morphometry. Thromb Haemost. 1988;60:392-398.
17. Kotze HF, Lamprecht S, Badenhorst PN. A four hour infusion of recombinant hirudin results in long-term inhibition of arterial-type thrombosis in baboons. Blood. 1995;85:3158-3163.
18. Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA. Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis. Circulation. 1990;82:578-585.
19. Schneider PA, Kotze HF, Heyns. A du P, Hanson SR. Thromboembolic potential of synthetic vascular grafts in baboons. J Vasc Surg. 1989;10: 75-82.
20. Lassila R, Badimon JJ, Vallabhajosula S, Badimon L. Dynamic monitoring of platelet deposition on severely damaged vessel wall in flowing blood: effects of different stenoses on thrombus growth. Arteriosclerosis. 1990;10:306-315.
21. Heras M, Chesebro JH, Webster MW, Mruk JS, Grill DE, Penny WJ, Bowie EJ, Badimon L, Fuster V. Hirudin, heparin and placebo during deep arterial injury in the pig: the in vivo role of thrombin in platelet-mediated thrombosis. Circulation. 1990;82:1476-1484.
22. Folts JD, Schafer AI, Loscalzo J, Willerson JT, Muller JE. A perspective on the potential problems with aspirin as an anti-thrombotic agent: a comparison of studies in an animal model with clinical trials. J Am Coll Cardiol. 1999;33:295-303.