Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats

Arzneimittel-Forschung/Drug Research

Volumn 50, Issue 3, 2000, Pages 227-231

  Ma, Tian Cai ^a,b   Zhu, Xing Zu ^b  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

6 Keto prostaglandin F(1 ); CAS 2149 70 4; CAS 53 86 1; Hippocampal; In vivo studies; Indometacin; Interleukin 6; N(G) nitro L arginine; Nitric oxide; Passive avoidance; Pharmacology

Indexed keywords

INDOMETACIN; INTERLEUKIN 6; N(G) NITROARGININE; NITRIC OXIDE; NITRITE; PROSTAGLANDIN;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INDUCTION; HIPPOCAMPUS; NONHUMAN; PASSIVE AVOIDANCE; PATHOGENESIS; RAT; TASK PERFORMANCE;

EID: 0034101047     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300190     Document Type: Article

References (15)

1. [1] Bauer, J., Strauss, U., Schreiter-Gasser, U. et al., Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett. 285, 111 (1991)
2. [2] Campbell, I. L., Abraham, C. R., Masliah, E. et al., Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6. Proc. Natl. Acad. Sci. USA 90, 10061 (1993)
3. [3] Hüll, M., Strauss, S., Berger, M. et al., The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer disease. Behav. Brain Res. 78, 37 (1996)
4. [4] Fiebich, B. L., Hüll, M., Lieb, K. et al., Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer disease. J. Neural Transm. Suppl. 54, 268 (1998)
5. [5] Ma, T. C, Zhu, X. Z., Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats. Acta Pharmacol. Sin. 18, 121 (1997)
6. 2 release in rats by indometacin. Arzneim.-Forsch./Drug Res. 47 (I), 595 (1997)
7. [7] Böhme, G. A., Bon, C., Lemaire, M. et al., Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc. Natl. Acad. Sci. USA 90, 9191 (1993)
8. [8] Geiger, P. J., Bessman, S. P., Protein determination by Lowry's method in the presence of sulphydryl reagent. Anal. Biochem. 49, 467 (1972)
9. [9] Misko, T. P., Schilling, R. J., Salvemini, D. et al., A fluorometric assay for the measurement of nitrite in biological samples, Anal. Biochem. 214, 11 (1993)
10. [10] Paxinos, G., Watson, C., The rat brain in stereotaxic coordinates Academic Press, New York (1982)
11. [11] Huang, A. M., Lee, E. H. Y., Role of hippocampal nitric oxide in memory retention in rats. Pharmacol. Biochem. Behav. 50, 327 (1995)
12. [12] Rogers, J., Inflammation as a pathogenic mechanism in Alzheimer's disease. Arzneim.-Forsch./Drug Res. 45 (I), 439 (1995)
13. [13] Lanzrein, A. S., Johnston, C. M., Perry, V. H. et al., Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor receptors I and II, and alpha 1-antichymotrypsin. Alzheimer Dis. Assoc. Disord. 12, 215 (1998)
14. [14] Dawson, T. M., Snyder, S. H., Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14, 5147 (1994)
15. [15] Wong, M. L., Rettori, V., Al-Shekhlee, A. et al., Inducible nictic oxide synthase gene expression in the brain during systemic inflammation. Nature Med. 2, 581 (1996)