Pancytopenia and valproic acid: A dose-related association

Journal of the American Geriatrics Society

Volumn 48, Issue 3, 2000, Pages 349-350

  Oluboka, O J ^a   Haslam, D ^b   Gardner, D M ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b North Bay Psychiatric Hospital   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CLONAZEPAM; MOCLOBEMIDE; VALPROIC ACID;

ADULT; BLOOD CELL COUNT; CASE REPORT; DRUG INDUCED DISEASE; HUMAN; LETTER; MALE; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; PANCYTOPENIA; PSYCHOPHARMACOTHERAPY; TREATMENT OUTCOME;

AGED; ANTIMANIC AGENTS; BIPOLAR DISORDER; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; PANCYTOPENIA; VALPROIC ACID;

EID: 0034101004     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2000.tb02668.x     Document Type: Letter

References (14)

1. Lambert PA, Cavaz G., Borsclli S., et al,. Action neuropsychotrope d'un nouvel anti-epiieptique: Le D-pamide. Ann Med Psychol (Paris) 1966; 1: 707-710.
2. Calabrese JR, Markovitz PJ, Kimmel SE, et al,. Spectrum of efficacy of valproate in 78 rapid-cycling bipolar patients. J Clin Psychopharmacol 1992; 12: 53-56S.
3. McElroy SL, Kech PE Jr., Pope HG Jr., et al,. Valproate in bipolar disorder; Literature review and treatment guidelines. J Clin Psychopharmacol 1992; 12: 42-52S.
4. Anonymous. Sodium valproate. Lancet 1988; 2: 1229-1231.
5. Smith MC, Bleck TP,. Convulsive disorders: Toxicity of anticonvulsants. Clin Neuropharmacol 1991; 14: 97-115.
6. Schatzberg RF, Nemeroff CB,. The American Psychiatric Press Textbook of Psychopharmacology, 1st Ed., Washington DC: American Psychiatric Press Inc. 1998, pp 362-363.
7. May RB, Sunder TR,. Hematologic manifestations of long-term valproate therapy. Epilepsia 1993; 34: 1098-1101.
8. Pappo AS, Fields BW, Buchanan GR,. Etiology of red blood cell macrocytosis during childhood: Impact of new diseases and therapies. Pediatrics 1992; 89: 1063-1067.
9. Tohen M., Castillo PHJ, Baldessarini RJ, et al,. Blood dyscrasias with carbamazepine and valproate: A pharmacoepidemiological study of 2228 patients at risk. Am J Psychiatry 1995; 152: 413-418.
10. Williams WJ, Beutler E., Erslev AJ, Lichtman MA,. Hematology, 4th Ed. Milan: McGraw-Hill, 1990, pp 158-176.
11. Saundler RM, Bevan PC, Roberts GE, et al,. Interaction between sodium, valproate and platelets: A further study. BMJ 1979; 2: 1476.
12. Saundler PM, Emberson C., Roberts GE, et al,. IgM platelet auto antibody due to sodium valproate. BMJ 1978; 2: 1683-1684.
13. Kaya IS, Dilmen U., Toppare M., et al,. Valproic acid induced pancytopenia and Coombs test positivity. Lancet 1991; 337: 1227-1228.
14. Robinson D., Langer A., Casso D., et al,. Pancytopenia and valproic acid-A possible association. J Am Geriatr Soc 1995; 43: 198.