Widespread elevated expression of the human papilloma virus (HPV)-activating cellular transcription factor Brn-3a in the cervix of women with CIN3 (cervical intraepithelial neoplasia stage 3)

Clinical Science

Volumn 98, Issue 5, 2000, Pages 601-602

  Ndisang, Daniel ^a   Budhram Mahadeo, Vishwanie ^a   Singer, Albert ^b   Latchman, David S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b WHITTINGTON HOSPITAL   (United Kingdom)

Author keywords

Brn 3a; Cervical cancer; Human papilloma virus; Transforming proteins

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU4F1; UNCLASSIFIED DRUG;

CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LETTER; PRIORITY JOURNAL; UTERINE CERVIX; UTERINE CERVIX CANCER; VIRUS INFECTION; WART VIRUS;

EID: 0034100697     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0980601     Document Type: Letter

References (6)

1. 1 Durst, M., Gissmann, L., Ikenberg, H. and Zur Hausen, H. (1983) A papilloma virus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. U.S.A. 80, 3812-3815
2. 2 Cox, M. F., Meanwell, C. A., Maitland, N. J., Blackledge, G., Scully, C. and Jordan, J. A. (1986) Human papillomavirus type-16 homologous DNA in normal human ectocervix. Lancet ii, 157-158
3. 3 Storey, A., Thomas, M., Kalita, A. et al. (1998) Role of a p53 polymorphism in the development of human papillomavirus. Nature (London) 393, 229-234
4. 4 Morris, P. J., Theil, T., Ring, C. J. A., Lillycrop, K. A., Möröy, T. and Latchman, D. S. (1994) The opposite and antagonistic effects of the closely related POU family transcription factors on the activity of a target promoter are dependent upon differences in the POU domain. Mol. Cell. Biol. 14, 6907-6914
5. 5 Ndisang, D., Budhram-Mahadeo, V., Morris, P. J. and Latchman, D. S. (1999) The Brn-3a transcription factor plays a critical role in regulating HPV gene expression and determining the growth characteristics of cervical cancer cells. J. Biol. Chem. 274, 28521-28527
6. 6 Ndisang, D., Morris, P. J., Chapman, C., Ho, L., Singer, A. and Latchman, D. S. (1998) The HPV activating transcription factor Brn-3a is over expressed in CIN3 lesions. J. Clin. Invest. 101, 1687-1692