Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: State or trait marker status

International Clinical Psychopharmacology

Volumn 15, Issue 2, 2000, Pages 93-98

  Plein, H ^a   Berk, M ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Calcium; Electroconvulsive therapy; Peripheral marker; Platelet; Receptor; Serotonin

Indexed keywords

CALCIUM; SEROTONIN; SEROTONIN 2A RECEPTOR;

ADULT; AGED; ARTICLE; CALCIUM CELL LEVEL; CLINICAL ARTICLE; DEPRESSION; ELECTROCONVULSIVE THERAPY; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; SECOND MESSENGER; SPECTROFLUOROMETRY;

EID: 0034096128     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004850-200015020-00005     Document Type: Article

References (34)

1. 3H-LSD binding in blood platelets of depressed patients. Life Sci 44:725-734.
2. Berk M, Bodemer W, Van Oudenhove T, Butkow N (1995) The platelet intracellular response to serotonin is augmented in bipolar manic and depressed patients. Hum Psychopharmacol 10:189-193.
3. Biegon A, Weizman A, Karp L, Ram A, Tiano S, Wolff M (1987) Serotonin 5HT2 receptor binding in blood platelets - a peripheral marker for depression? Life Sci 41:2485-2492.
4. Blier P, de Montigny C, Chaput Y (1990) A role for the serotonin system in the mechanism of action of antidepressant treatments: pre-clinical evidence. J Clin Psychiatry 51:14-20.
5. Chaput Y, de Montigny C, Blier P (1991) Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments: an in vivo electrophysiologic study in the rat. Neuropsychopharmacology 5:219-229.
6. Cowen PJ, Charig EM, Fraser S, Elliott JM (1987) Platelet 5HT receptor binding during depressive illness and tricyclic antidepressant treatment. J Affect Disord 13:45-50.
7. Da Prada M, Cesura AM, Launay JM, Richards JG (1988) Platelets as a model for neurones? Experentia 44: 115-126.
8. Delisi SM, Konopka LM, O'Connor FL, Crayton JW (1998) Platelet cytosolic calcium responses to serotonin in depressed patients and controls: relationship to symptomatology and medication Biol Psychiatry 43:327-334.
9. De Montigny C (1984) Electroconvulsive shock treatments enhance responsiveness of forebrain neurons to serotonin. J Pharmacol Experimental Therapeut 228:230-234.
10. Dubovsky SL, Thomas M (1995) Beyond specificity: effects of serotonin and serotonergic treatments on psychobiological dysfunction. J Psychosomatic Res 39:429-444.
11. Dubovsky SL, Lee C, Christiano J, Murphy J (1991) Elevated platelet intracellular calcium concentration in bipolar depression. Biol Psychiatry 29:441-450.
12. Eckert A, Gann H, Riemann D, Aldenhoff J, Muller WE (1993) Elevated intracellular calcium levels after 5HT2 receptor stimulation in platelets of depressed patients. Biol Psychiatry 34:565-568.
13. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
14. Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M (1993) 5HT uptake sites and 5HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5HT2 sites in cortex and amygdala. Brain Res 614:37-44.
15. Hrdina PD, Bakish D, Chudzik J, Ravindran A, Lapierre YD (1995) Serotonergic markers in platelets of patients with major depression: upregulation of 5HT2 receptors. J Psychiatr Neurosci 20:11-19.
16. Hrdina PD, Bakish D, Ravindran A, Chudzik J, Cavazzoni P, Lapierre YD (1997) Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry Res 66:73-85.
17. Kellar KJ, Cascio CS, Butler JA, Kurtzke RN (1981) Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. Eur J Pharmacol 69:515-518.
18. Konopka LM, Cooper R, Crayton JW (1996) Serotonin-induced increases in platelet cytosolic calcium concentration in depressed, schizophrenic, and substance abuse patients. Biol Psychiatry 39:708-713.
19. Kusumi I (1993) Serotonin-2-receptor-mediated intraplatelet calcium mobilization in affective disorders: relevance to the pathophysiology of depression. Hokkaido Igaku Zasshi 68:325-336.
20. Leonard BE (1991) Blood cells as models of neurons: studies in the affective disorders. J Irish Coll Phys Surg 20:282-284.
21. Leonard BE (1992) Fundamentals of Psychopharmacology. Chichester: John Wiley.
22. Mann JJ, Malone KM, Diehl DJ, Perel J, Cooper TB, Mintun MA (1996) Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am J Psychiatry 153:174-182.
23. McBride PA, Brown RP, DeMeo M, Keilp J, Mieczkowski T, Mann J (1994) The relationship of platelet 5HT2 receptor indices to major depressive disorder, personality traits, and suicidal behavior. Biol Psychiatry 35:295-308.
24. Newman ME, Shapira B, Lerer B (1998) Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. Int J Neuropsychopharmacol 1:49-69.
25. O'Keane V, McLoughlin D, Dinan TG (1992) D fenfluramine-induced prolactin and cortisol release in major depression: response to treatment. J Affect Disord 26:143-150.
26. Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, et al. (1990) Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs. J Clin Psychiatry 51:44-50.
27. Shapira B, Lerer B, Kindler S, Lichtenberg P, Gropp C, Cooper T, Calev A (1992) Enhanced serotonergic responsivity following electroconvulsive therapy in patients with major depression. Br J Psychiatry 160:223-229.
28. Shapira B, Cohen J, Newman ME, Lerer B (1993) Prolactin response to fenfluramine and placebo challenge following maintenance pharmacotherapy withdrawal in remitted depressed patients. Biol Psychiatry 33:531-535.
29. Stahl SM (1977) The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Arch Gen Psychiatry 34:509-516.
30. Stahl S (1994) 5HT1A receptors and pharmacotherapy. Psychopharmacol Bull 30:39-43.
31. Stain-Malmgren R, Tham A, Aberg-Wistedt A (1998) Increased platelet 5HT2 receptor binding after electroconvulsive therapy in depression. J ECT 14:15-24.
32. Yates M, Leake A, Candy JM, Fairbairn AF, McKeith JG, Ferrier IN (1990) 5HT2 receptor changes in major depression. Biol Psychiatry 27:489-496.
33. Weiner RD, Krystal AD (1994) The present use of electro-convulsive therapy. Ann Rev Med 45:273-281.
34. Zhou D (1991) Comparison of the effects of four psychiatric treatments on rat brain beta 5HT2 receptors. Chung Hua Shen Ching Ching Shen Ko Tsa Chih 24:207-209:251-152.