Histological and ultrastructural findings suggesting an initiating role for Chlamydia pneumoniae in the pathogenesis of atherosclerosis: A study of 50 cases

Cardiovascular Journal of South Africa

Volumn 11, Issue 1, 2000, Pages 16-23

  Shor, Allan ^a,b   Phillips, James I ^a  

^a National Centre for Occupational Health   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; CHLAMYDOPHILA PNEUMONIAE; CLINICAL ARTICLE; GRANULOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ULTRASTRUCTURE;

EID: 0034095941     PISSN: 10159657     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hajjar DP, Nicholson AC. Atherosclerosis. American Scientist 1995; 83:460-467.
2. Ross R. The pathogenesis of atherosclerosis; a perspective for the 1990s. Nature 1993; 362: 801-809.
3. Benditt E, Schwartz SM. Blood vessels. In: Rubin E, Farber JL, eds. Pathology. Philadelphia: Lippincott, 1989: 459-477.
4. Woolf N. The morphology of the atherosclerotic lesion. In: Woolf N, ed. Pathology of Atherosclerosis. London: Butterworth, 1982: 47-83.
5. Ross R. Atherosclerosis. In: O'D McGee J, Isaacson PG, Wright NA, eds. Oxford Textbook of Pathology. Oxford: Oxford University Press, 1992: 798-812.
6. Ellis RW. Infection and coronary heart disease. J Med Microbiol 1997; 46:535-539.
7. Grayston JT, Kuo C-C, Wang S-P, Altman J. A new Chlamydia psittici strain, TWAR isolated in acute respiratory tract infections. N Engl J Med 1986;315: 161-168.
8. Shor A, Kuo C-C, Patton DL. Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S Afr Med J 1992; 82: 158-161.
9. Kuo C-C, Shor A, Campbell LA, Fukushi H, Patton DL, Grayston JT. Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. J Infect Dis 1993; 167: 841-849.
10. Kuo C-C, Gown AM, Benditt EP, Grayston JT. Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immuno-cytochemical stain. Arterioscler Thromb 1993; 13: 1501-1504.
11. Kuo C-C, Grayston JT, Campbell LA, Goo YA, Wissler RW, Benditt E. Chlamydia pneumoniae (TWAR) in coronary arteries of young adults. Proc Natl Acad Sci USA 1995; 92: 6911-6914.
12. Campbell LA, O'Brien ER, Cappuccio AL, et al. Detection of Chlamydia pneumoniae (TWAR) in human coronary atherectomy tissue. J Infect Dis 1995; 172: 585-588.
13. Muhlestein JB, Hammond EH, Carlquist JF, et al. Increased incidence of Chlamydia species within the coronary arteries of patients with symptomatic atherosclerotic versus other forms of cardiovascular disease. J Am Coll Cardiol 1996; 127: 1555-1561.
14. Kuo C-C, Grayston JT, Campbell LA, Jackson L, Wang S-P. Chlamydia pneumoniae lives in most atherosclerotic lesions. 4th International Conference on the Macrolides, Azalides, Streptogramins and Ketolides, Barcelona, Spain, 21-23 Jan 1998 (abstract 4.08).
15. Ong G, Thomas BJ, Mansfield AO, Davidson BR, Taylor-Robinson D. Detection and widespread distribution of Chlamydia pneumoniae in the vascular system and its possible implications. J Clin Pathol 1996; 49: 102-196.
16. Juvonene J, Juvonene T, Laurila A, et al. Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms. J Vasc Surg 1997; 25: 499-505.
17. Blasi F, Denti F, Erba M, et al. Detection of Chlamydia pneumoniae but not Helicobacter pylori in atherosclerotic plaques of aortic aneurysms. J Clin Microbiol 1996; 34: 2766-2769.
18. Kuo C-C, Coulson AS, Campbell LA, et al. Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction. J Vasc Surg 1997; 26: 29-31.
19. Shor A, Phillips JI, Ong G, Thomas BJ, Taylor-Robinson D. Chlamydia pneumoniae in atheroma: consideration of criteria for causality. J Clin Pathol 1998; 51: 812-817.
20. Ramirez JA. and the Chlamydia pneumoniae/Atherosclerosis Study Group. Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis. Ann Intern Med 1996; 125: 979-982.
21. Jackson LA, Campbell LA, Kuo C-C, et al. Isolation of Chlamydia pneumoniae from a carotid endarterectomy specimen. J Infect Dis 1997; 176: 292-295.
22. Maass M, Bartels C, Engel PM, et al. Endovascular presence of viable Chlamydia pneumoniae is a common phenomenon in coronary artery disease. J Am Coll Cardiol 1998;31: 827-832.
23. Weiss SM, Roblin PM, Gaydos CA, et al. Failure to detect Chlamydia pneumoniae in coronary atheromas of patients undergoing atherectomy. J Infect Dis 1996; 173:957-962.
24. Taylor-Robinson D, Thomas BJ. Chlamydia pneumoniae in arteries: the facts, their interpretation, and future studies. J Clin Pathol 1998; 51: 793-797.