The intraperitoneal Plasmodium berghei-Pasteur infection of Swiss mice is not a system that is able to detect the antiplasmodial activity in the Pothomorphe plant extracts that are used as antimalarials in Brazilian endemic areas

Experimental Parasitology

Volumn 94, Issue 4, 2000, Pages 243-247

  Ferreira Da Cruz, Maria De Fátima ^a   Adami, Yara L ^a   Espinola Mendes, Érika Da Cruz ^a   Figueiredo, Maria Raquel ^a   Daniel Ribeiro, Cláudio T ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antimalarial activity; Malaria; Medicinal plants; Plasmodium berghei; Pothomorphe peltata; Pothomorphe umbellata

Indexed keywords

ANTIMALARIAL AGENT; PLANT EXTRACT; POTHOMORPHE EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; BRAZIL; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG ISOLATION; DRUG SCREENING; ENDEMIC DISEASE; FEMALE; MALARIA; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PRIORITY JOURNAL;

EID: 0034094492     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.2000.4494     Document Type: Article

References (13)

1. Adami Y. L., Milhous W., Daniel-Ribeiro C. T., Ferreira-da-Cruz M. F. In vitro antimalarial activity of crude extracts of Pothomorphe peltata and P. umbellata (Piperaceae). Tropical Medicine. 40:1998;91-94.
2. Amorim C. Z., Flores C. A., Gomes B. E., Marques A. D., Cordeiro R. S. B. Screening for antimalarial activity in the genus Pothomorphe. Journal of Ethnopharmacology. 24:1988;101-106.
3. Bruce-Chwatt L. J., Black R. H., Canfield C. J., Clyde D. F., Peters W., Wernsdorfer W. H. Chemotherapy of Malaria. 1981;World Health Organization.
4. Cabral J. A., McChesney J. D., Milhous W. K. A new antimalarial quassinoid from Simaba guianensis. Journal of Natural Products. 11:1993;1954-1961.
5. Carvalho L. H., Brandãto M. G. L., Santos-Filho D., Lopes J. C., Krettli A. U. Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in culture. Brazilian Journal of Medical and Biological Research. 24:1991;1113-1123.
6. Cordeiro R. S. B., Cunha F. Q., Filho J. A., Flores C. A., Vasconcelos H. N., Martins M. A. Plasmodium berghei: Physiopathological changes during infections in mice. Annals of Tropical Medicine and Parasitology. 77:1983;455-465.
7. Cruz G. L. Dicionário das Plantas Úteis do Brasil. 1985;Civilização Brasileira, Rio de Janeiro.
8. Klayman D. L. Qinghaosu (artemisinin): An antimalarial drug from China. Science. 228:1985;1049-1054.
9. Matos F. J. A. Introdução Fitoquímica Experimental. 1988;Cejub, Ceará
10. Peters W. Drug resistance in Plasmodium berghei Vincke & Lips: Chloroquine resistance. Experimental Parasitology. 17:1965;80-89.
11. Peters W. Malaria: Epidemiology, Chemotherapy, Morphology and Metabolism. 1980;Academic Press.
12. Steele J. C., Warhurst D. C., Kirby G. C., Simmonds M. S. In vitro and in vivo evaluation of betulinic acid as antimalarial. Phytotherapy Research. 13:1999;115-119.
13. Vincke I. H., Lips M. Un nouveau plasmodium d'un rangeur du Congo (Plasmodium berghei n.sp.). Annals Societé Belgique Medicine Tropicale. 28:1948;97.