High insulin and low IGF-I plasma levels following pancreas transplantation in rats. Implications for bone and mineral metabolism

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 60, Issue 3, 2000, Pages 175-188

  Kissler, Hermann J ^a   Hofmann, G ^a   Gepp, H ^a   Erben, R G ^b   Schwille, P O ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Histomorphometry; Insulin resistance; Markers of bone metabolism; Oral glucose tolerance test; Orthotopic pancreas transplantation; Portal venous drainage

Indexed keywords

INSULIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE METABOLISM; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN DEFICIENCY; INSULIN RESISTANCE; INTESTINE ABSORPTION; MINERAL METABOLISM; NONHUMAN; OSTEOPENIA; PANCREAS TRANSPLANTATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

ANIMALIA;

EID: 0034094119     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655100750044820     Document Type: Article

References (59)

1. 1 Silberberg R. The skeleton in diabetes mellitus: a review of the literature. Diabetes Res 1986; 3: 329-38.
2. 2 Piepkorn B, Kann P, Forst T, Andreas J, Pfützner A, Beyer J. Bone mineral density and bone metabolism in diabetes mellitus. Horm Metab Res 1997; 29: 584-91.
3. 3 Bouillon R. Diabetic bone disease. Calcif Tissue Int 1991; 49; 155-60.
4. 4 Bouillon R. Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. Verh K Acad Geneeskd Belg 1992; 54: 365-92.
5. 5 McNair P. Bone mineral metabolism in human type I (insulin dependent) diabetes mellitus. Dan Med Bull 1988; 35: 109-21.
6. 6 Locatto ME, Fernandez MC, Caferra DA, Puche RC. The long-term effects of pancreatectomy on the Ca metabolism in the rat. Acta Diabetol Lat 1983; 20: 297-302.
7. 7 Weber CJ, Hardy MA, Williams GA, Lerner RL, Reemtsma K. Pancreatic islet transplantation and hyperparathyroidism in diabetic rats. Surg Forum 1976; 27: 317-20.
8. 8 Silberberg R, Scharp DW, Lesker PA. Biochemical studies of bone from diabetic rats and rats bearing transplanted pancreatic islets. Exp Cell Biol 1981; 49: 61-7.
9. 9 Nozawa M, Otsu I, Ikebukuro H, Ishida H, Seino Y, Taminato T. Reversal of osteopenia in streptozotocin diabetic rats by pancreatic transplantation. Life Support Syst 1985; 3 Suppl 1: 685-90.
10. 10 Derfus BA, Carrera GF, Komorowski RA, Ryan LM. Severe arthropathy and osteopathy following combined renal/pancreas transplantation. Transplantation 1992; 53: 678-81.
11. 11 Ishida H, Seino Y, Takeshita N, Kurose T, Tsuij K, Okamoto Y, et al. Effect of pancreas transplantation on decreased levels of circulating bone gamma-carboxyglutamic acid-containing protein and osteopenia in rats with streptozotocin-induced diabetes. Acta Endocrinol 1992; 127: 81-5.
12. 12 Cesnjevar R, Schwille PO, Kissler H, Berge B, Köckerling F, Fries W, et al. Impairment of bone and mineral metabolism after pancreatic transplantation: observations in syngeneic rats. Eur J Surg 1997; 163: 851-9.
13. 13 Chiu MY, Sprague SM, Bruce DS, Woodle ES, Thistlewaite JR. Jr., Josephson MA. Analysis of fracture prevalence in kidney-pancreas allograft recipients. J Am Soc Nephrol 1998; 9: 677-83.
14. 14 Smets YF, van der Pijl JW, de Fijter JW, Ringers J, Lemkes HH, Hamdy NA. Low bone mass and high incidence of fractures after successful simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant 1998; 13: 1250-5.
15. 15 Smets YF, van der Pijl JW, Ringers J, de Fijter JW, Lemkes HH, Hamdy NA. Pattern of bone loss after simultaneous pancreas kidney transplantation: a prospective study. Transplant Proc 1998; 30: 326.
16. 16 Chicheportiche D, Darquy S, Lepeintre J, Capron F, Halban PA, Reach G. High-performance liquid chromatography analysis of circulating insulins distinguishes between endogenous insulin production (a potential pitfall with streptozotocin diabetic rats) and islet xenograft function. Diabetologia 1990; 33: 457-61.
17. 17 Cvetkovic M, Mann GN, Romero DF, Liang XG, Ma Y, Jee WS, et al. The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. Transplantation 1994; 57: 1231-7.
18. 18 Ziegler R, Kasperk C. Glucocorticoid-induced osteoporosis: prevention and treatment. Steroids 1988; 63: 344-8.
19. 19 Diem P, Abid M, Redmon JB, Sutherland DE, Robertson RP. Systemic venous drainage of pancreas allograft as independent cause of hyperinsulinemia in type I diabetic recipients. Diabetes 1990; 39: 534-40.
20. 20 Meister R, Schwille PO. Intraportale Transplantation des Duodeno-Pankreas bei der Ratte. Chir Gastroenterol 1991; Suppl ; 7: 23-6.
21. 21 Zimmermann FA, Butcher GW, Davies HS, Brons G, Kamada N, Türel O. Techniques for orthotopic liver transplantation in the rat and some studies of the immunologic responses to fully allogeneic liver grafts. Transplant Proc 1979; 11: 571-7.
22. 22 Kissler H, Gepp H, Schmiedl A, Schwille PO. Preserved incretin effect after orthotopic pancreas transplantation in inbred rats. Metabolism 1999; 48: 645-50.
23. 23 Draper HH, Sie TL, Bergan JG. Osteoporosis in aging rats induced by high phosphorus diets. J Nutr 1972; 102: 1133-41.
24. 24 Shevock PN, Khan SR, Hackett RL. Urinary chemistry of the normal Sprague-Dawley rat. Urol Res 1993; 21: 309-12.
25. 25 Schenk R, Olah A, Herrmann W. Preparation of calcified tissues for light microscopy. In: Dickson G, editor. Methods of calcified tissue preparation. Amsterdam: Elsevier; 1984. p. 1-56
26. 26 Erben RG, Kohn B, Rambek WA, Zucker H. Histomorphometric analysis of the rat proximal tibial metaphysis by "linear scanning". Scanning Microsc 1990; 4: 625-38.
27. 27 Baron R, Vignery A, Neff L, Silverglate A, Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR, editor. Bone histomorphometry: techniques and interpretation. Boca Raton: CRC Press; 1983. p. 13-35
28. 28 Rümenapf G, Schwille PO, Erben RG, Schreiber M, Fries W, Schmiedl A, et al. Osteopenia following total gastrectomy in the rat - state of mineral metabolism and bone histomorphometry. Eur Surg Res 1997; 29: 209-21.
29. 29 Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987; 2: 595-610.
30. 30 Herbert V, Lau K-S, Gottlieb CW, Bleicher SJ. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 1965; 25: 1375-84.
31. 31 Akpan JO, Weide LG, Gingerich RL. A specific and sensitive radioimmunoassay for rat C-peptide. Int J Pancreatol 1993; 13: 87-95.
32. 32 Aguilar-Parada E, Eisentraut AM, Unger RH. Pancreatic glucagon secretion in normal and diabetic subjects. Am J Med Sci 1969; 257: 415-9.
33. 33 Chance RE, Moon NE, Johnson MG. Human pancreatic polypeptide (HPP) and bovine pancreatic polypeptide (BPP). In: Jaffe BM, Behrman HR, editors. Methods of hormone radioimmunoassays. New York: Academic Press; 1979. p. 657-72
34. 34 Goverde BC, Veenkamp FJ. Routine assay of total urinary hydroxyproline based on resin-catalysed hydrolysis. Clin Chim Acta 1972; 41: 29-40.
35. 35 Chen PJ, Toribara T, Warner H. Microdetermination of phosphorus. Anal Chem 1956; 28: 1756-8.
36. 36 Ebert R, Illmer K, Creutzfeldt W. Release of gastric inhibitory polypeptide (GTP) by intraduodenal acidification in rats and humans and abolishment of the incretin effect of acid by GIP-antiserum in rats. Gastroenterology 1979; 76: 515-23.
37. 37 Shuster LT, Go VL, Rizza RA, O'Brien PC, Service FJ. Incretin effect due to increased secretion and decreased clearance of insulin in normal humans. Diabetes 1988; 37: 200-3.
38. 38 Parfitt AM. Chlorothiazide-induced hypercalcemia in juvenile osteoporosis and hyperparathyroidism. N Engl J Med 1969; 281: 55-9.
39. 39 Graves K, Wolinsky I. Calcium and phosphorus metabolism in pregnant rats ingesting a high protein diet. J Nutr 1980; 110: 2420-32.
40. 40 Saville PD, Smith R. Bone density, breaking force and leg muscle mass as functions of weight in bipedal rats. Am J Phys Anthrop 1966; 25: 35-9.
41. 41 Anderson GH, Draper HH. Effect of dietary phosphorus on calcium metabolism in intact and parathyroidectomized adult rats. J Nutr 1972; 102: 1123-32.
42. 42 Luzi L, Battezzati A, Perseghin G, Bianchi E, Vergani S, Secchi A, et al. Lack of feedback inhibition of insulin secretion in denervated human pancreas. Diabetes 1992; 41: 1632-9.
43. 43 Boden G, Chen X, DeSantis R, Kolaczynski J, Morris M. Evidence that suppression of insulin secretion by insulin itself is neurally mediated. Metabolism 1993; 42: 786-9.
44. 44 Jaspan J, Polonsky K. Glucose ingestion in dogs alters the hepatic extraction of insulin. In vivo evidence for a relationship between biologic action and extraction of insulin. J Clin Invest 1982; 69: 516-25.
45. 45 Schneider LE, Nowosielski LM, Schedl HP. Insulin-treatment of diabetic rats: effects on duodenal calcium absorption. Endocrinology 1977; 100: 67-73.
46. 46 Hough S, Russell JE, Teitelbaum SL, Avioli LV. Calcium homeostasis in chronic streptozotocin-induced diabetes mellitus in the rat. Am J Physiol 1982; 242: E451-6.
47. 47 Wood RJ, Allen LH, Bronner F. Regulation of calcium metabolism in streptozotocin-induced diabetes. Am J Physiol 1984; 247: R120-3.
48. 48 Nyomba BL, Verhaeghe J, Thomasset M, Lissens W, Bouillon R. Bone mineral homeostasis in spontaneously diabetic BB rats. I. Abnormal vitamin D metabolism and impaired active intestinal calcium absorption. Endocrinology 1989; 124: 565-72.
49. 49 Rümenapf G, Issa S, Schwille PO. The influence of progressive hyperinsulinemia on duodenal calcium absorption in the rat. Metabolism 1987; 36: 60-5.
50. 50 Rümenapf G, Schmidtler J, Schwille PO. Intestinal calcium absorption during hyperinsulinemic euglycemic glucose clamp in healthy humans. Calcif Tissue Int 1990; 46: 73-9.
51. 51 Henry HL. Insulin permits parathyroid hormone stimulation of 1,25-dihydroxyvitamin D3 production in cultured kidney cells. Endocrinology 1981; 108: 733-5.
52. 52 Hough S, Avioli LV, Bergfeld MA, Fallen MD, Slatopolsky E, Teitelbaum SL. Correction of abnormal bone and mineral metabolism in chronic streptozotocin-induced diabetes mellitus in the rat by insulin therapy. Endocrinology 1981; 108: 2228-34.
53. 53 Rosato MT, Schneider SH, Shapses SA. Bone turnover and insulin-like growth factor I levels increase after improved glycemic control in non-insulin-dependent diabetes mellitus. Calcif Tissue Int 1998; 63: 107-11.
54. 54 Cakatay U, Telci A, Kayali R, Akcay T, Sivas A, Aral F. Changes in bone turnover on deoxypyridinoline levels in diabetic patients. Diabetes Res Clin Pract 1998; 40: 75-9.
55. 55 Nyomba BL, Berard L, Murphy LJ. Free insulin-like growth factor I (IGF-I) in healthy subjects: relationship with IGF-binding proteins and insulin sensitivity. J Clin Endocrinol Metab 1997; 82: 2177-81.
56. 56 Zhuang HX, Wuarin L, Fei ZJ, Ishij DN. Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy. J Pharmacol Exp Ther 1997; 283: 366-74.
57. 57 Hock JM, Centrella M, Canalis E. Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 1988; 122: 254-60.
58. 58 Raisz LG. Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 1988; 318: 818-28.
59. 59 Verhaeghe J, van Herck E, Visser WJ, Suiker AM, Thomasset M, Einhorn TA, et al. Bone and mineral metabolism in BB rats with long-term diabetes. Decreased bone turnover and osteoporosis. Diabetes 1990; 39: 477-82.