EDG receptors as a therapeutic target in the nervous system

Annals of the New York Academy of Sciences

Volumn 905, Issue , 2000, Pages 118-131

  Beer, Margaret S ^a   Stanton, Josephine A ^a   Salim, Kamran ^a   Rigby, Michael ^a   Heavens, Robert P ^a   Smith, David ^a   McAllister, George ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; RECEPTOR SUBTYPE;

ANIMAL TISSUE; APOPTOSIS; BRAIN REGION; CELL GROWTH; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSKELETON; DRUG SCREENING; DRUG TARGETING; EMBRYO; EPENDYMA CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; MULTIGENE FAMILY; MULTIPLE SCLEROSIS; MYELINATION; NERVE CELL; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVOUS SYSTEM; NONHUMAN; PROTEIN LOCALIZATION; RAT; RECEPTOR GENE; SECOND MESSENGER; WHITE MATTER;

ANIMALIA; MAMMALIA;

EID: 0034093521     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06544.x     Document Type: Conference Paper

References (19)

1. 1. HLA, T. & T. MACIAG. 1990. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J. Biol. Chem. 265: 9308-9313.
2. 2. GOETZL, E.J. & S. AN. 1998. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 12: 1589-1598.
3. 3. GRALER, M.H., G. BERNHARDT & M. LIPP. 1998. EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics 53: 164-169.
4. i-family G-proteins: studies with pertussis toxin-resistant G-protein mutants. Biochem. J. 321: 721-728.
5. 5. SIRINATHSINGHJI, D.J. & S.B. DUNNETT. 1993. Molecular Imaging in Neuroscience, N.A. Sharif, Ed.: 43-70. Oxford Univ. Press. London.
6. 6. LUI, C.H. & T. HLA. 1997. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics 43: 15-24.
7. 7. LADO, D.C., C.S. BROWE, A.A. GASKIN, J.M. BORDEN & A.J. MACLENNAN. 1994. Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions. Gene 149: 331-336.
8. 8. YAMAGUCHI, F., M. TOKUDA, O. HATASE & S. BRENNER. 1996. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochem. Biophys. Res. Commun. 227: 608-614.
9. 9. ZHANG, G., J.J.A. CONTOS, J.A. WEINER, N. FUKUSHIMA & J. CHUN. 1999. Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 227: 89-99.
10. 10. AN, S., T. BLEU, O.G. HALLMARK & E.J. GOETZL. 1998. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273: 7906-7910.
11. 11. WEINER, J.A., J.H. HECHT & J. CHUN. 1998. Lysophosphatidic acid receptor gene vzg-1/1pa1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J. Comp. Neurol. 398: 587-598.
12. 12. WEINER, J.A. & J. CHUN. 1999. Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc. Natl. Acad. Sci. USA 96: 5233-5238.
13. 13. ALLARD, J., S. BARRON, J. DIAZ, C. LUBETZKI, B. ZALC, J.-C. SCHWARTZ & P. SOKOLOFF. 1998. A rat G protein-coupled receptor selectivity expressed in myelin-forming cells. Eur. J. Neurosci. 10: 1045-1053.
14. 14. ALLARD, J., S. BARRON, S. TROTTIER, P. CERVERA, C. DAUMAS-DUPORT, E. LEGUERN, A. BRICE, J.-C. SCHWARTZ & P. SOKOLOFF. 1999. Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in charcot-marie-tooth disease. Glia 26: 176-185.
15. 15. VAN BROCKLYN, J.R., Z. TU, L.C. EDSALL, R.R. SCHMIDT & S. SPIEGEL. 1999. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. J. Biol. Chem. 274: 4626-4632.
16. 16. HOLTSBERG, F.W., M.R. STEINER, J.N. KELLER, R.J. MARK, M.P. MATTSON & S.M. STEINER. 1998. Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons. J. Neurochem. 70: 66-76.
17. 17. HOLTSBERG, F.W., M.R. STEINER, A.J. BRUCE-KELLER, J.N. KELLER, M.P. MATTSON, J.C. MOYERS & S.M. STEINER. 1998. Lysophosphatidic acid and apoptosis of nerve growth factor-differentaited PC12 cells. J. Neurosci. Res. 53: 685-696.
18. 18. ERIKSSON, P.S., E. PERFILIEVA, T. BJORK-ERIKSSON, A.-M. ALBORN, C. NORDBORG, D.A. PETERSON & F.H. GAGE. 1998. Neurogenesis in the adult human hippocampus. Nature Med. 4: 1313-1317.
19. 19. GOULD, E., P. TANAPAT, B. S. MCEWEN, G. FLUGGE & E. FUCHS. 1998. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. USA 95: 3168-3171.