Effects of nefazodone on the immune system of mice

European Neuropsychopharmacology

Volumn 10, Issue 4, 2000, Pages 255-264

  Freire Garabal, Manuel ^a   Varela, Milvia ^a   Riveiro, Pilar ^a   Balboa, José ^a   Liñares, David ^a   Mañá, Paula ^a   Mayán, Jose M ^a   Rey Méndez, Manuel ^a   Núñez, María J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Immunity; Mice; Nefazodone; Phagocytosis; Stress; T cells

Indexed keywords

CONCANAVALIN A; NEFAZODONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNITY; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN; STRESS; T LYMPHOCYTE; THYMUS;

EID: 0034092373     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(00)00080-8     Document Type: Article

References (55)

1. Ader, R., Felten, D., Cohen, N., 1990. Interactions between the brain and the immune system. Annu. Rev. Pharmacol. Toxicol. 30, 561–602.
2. Aune, T.M., Golden, H.W., McGrath, K.M., 1994. Inhibitors of serotonin synthesis and antagonists of serotonin IA receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo. J. Immunol. 153 (2), 489–498.
3. Ameisen, J.C., Meade, R., Askenase, P.W., 1989. A new interpretation of the involvement of serotonin in delayed-type of hypersensitivity. J. Immunol. 142, 3171–3179.
4. Ben-Eliyahu, S., Yirmiya, R., Shavit, Y., Liebeskind, J.C., 1990. Stress-induced suppression of natural killer cell cytotoxicity in the rat: a paradigm. Behav. Neurosci. 104 (1), 235–238. naltrexone-insensitive
5. Blalock, J.E., 1990. Molecular mechanisms of bidirectional communica-tion between the immune and neuroendocrine systems. Int. J. Neuro-sci. 51, 363–364.
6. Blalock, J.E., Bost, K.L., Smith, E.M., 1985. Neuroendocrine peptide hormones and their receptors in the immune system. Production, processing and action. J. Neuroimmunol. 10, 31–40.
7. Bullock, K., 1987. The innervation of immune system tissues and organs. In: Cotman, C.W., Brinton, R.E., Galaburda, A., McEwen, B. (Eds.), The Neuro-Immune-Endocrine Connection, Raven Press, New York, pp. 33–47.
8. Davis, R., Whittington, R., Bryson, H.M., 1997. Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs 53 (4), 608–636.
9. 3 H1-dopamine uptake by human lymphocytes: correlates with serotonin transporter activity. Pharmacology 48, 320–327.
10. Freire-Garabal, M., Belmonte, A., Balboa, J.L., Nidiez, M.J., 1992. Effects of midazolam on T-cell immunosuppressive response to surgical stress in mice. Pharmacol. Biochern. Behav. 43, 85–89.
11. Freire-Garabal, M., Belinonte, A., Suarez-Quintanilla, J.A., 1991. Effects of buspirone on T-cell immunosuppressive response to stress in mice. Arch. Int. Pharmacodyn. Therap. 314, 160–168.
12. Freire-Garabal, M., Couceiro, J., Balboa, J.L. et al., 1991d. Effects of diazepam on the resistance, on the development of immunity and on the passive transfer of immunity to Listeria monocyto genes in mice submitted to surgical stress. Acta Therap. 17 (4), 1–8.
13. Freire-Garabal, M., Nunez, M.J., Balboa, J.L., Belmonte-Otero, A., Belmonte, A., 1991b. Effects of buspirone on the development of MTV-induced mammary tumors in female mice under stress. Res. Commun. Psych. Psy. 16, 107–114.
14. Freire-Garabal, M., Nunez, M.J., Balboa, J.L. et al., 1993. Effects of alprazolam on cellular immune response to surgical stress in mice. Cancer Lett. 73, 155–160.
15. Freire-Garabal, M., Nunez, M.J., Balboa, J.L., Fernandez-Rial, J.C., Rey-Mendez, M., 1995. Effects of buspirone on the immune response to stress in mice. Pharmacol. Biochem. Behav. 51, 821–825.
16. Freire-Garabal, M., Nunez, M.J., Balboa, J.L., Suarez, J.A., Belmonte, A., 1991c. Effects of alprazolam on the development of MTV-induced mammary tumors in female mice under stress.Cancer Lett. 62, 185–189.
17. Freire-Garabal, M., Nunez, M.J., Fernandez-Rial, J.C., Balboa, J.L., Couceiro, J., Belmonte, A., 1993d. Effects of alprazolam on influenza virus infection in stressed mice. Pharmacol. Biochem. Behav. 46, 167–172.
18. Freire-Garabal, M., Nunez, M.J., Fernandez-Rial, J.C., Couceiro, J., Garcia-Vallejo, L.A., Rey-Mendez, M., 1993b. Phagocytic activity in stressed mice5effects of alprazolam. Res. Immunol. 144, 311–316.
19. Freire-Garabal, M., Nunez, M.J., Fernandez-Rial, J.C., Rey-Mendez, M., Belmonte, A., 1993e. Effects of buspirone on the resistance, development and passive transfer of immunity to Listeria monocytogenes in mice submitted to stress. Arch. Int. Pharmacodyn. Therap. 324, 114– 123.
20. Freire-Garabal, M., Nunez, M.J., Losada, C. et al., 1995b. Effects of buspirone on delayed type hypersensitivity (DTH) response in stressed mice. Res. Commun. Psych. Psy. 20, 49–57.
21. Freire-Garabal, M., Nunez, M.J., Losada, C. et al., 1997. Effects of fluoxetine on the immunosuppressive response to stress in mice. Life Sci. 60, 403–413.
22. tases Freire-Garabal, M., Nunez-Iglesias, M.J., Balboa, J.L. et al., 1993c. Inhibitory effects of alprazolam on the enhancement of lung metas-induced by operative stress in rats. Int. J. Oncol. 3, 513–517.
23. Freire-Garabal, M., Nunez-Iglesias, M.J., Losada, C. et al., 1995c. Effects of buspirone on influenza A virus infection in stressed mice. Life Sci. 56, 187–193.
24. �effects Fride, E., Meng, R., Skolnick, P., Arora, P.K., 1992. Immunoenhancing of alprazolam, a benzodiazepine receptor agonist. Ann. NY Acad. Sci. 15 (650), 132–139.
25. Galdiero, F., Bentivoglio, C., Nuzzo, I. et al., 1995. Effects of benzodiazepines on immunodeficiency and resistance in mice. Life Sci. 57 (26), 2413–2423.
26. Garssen, J., Van-Loveren, H., Van-Der-Vliet, H., Bot, H., Nijkamp, F.P., 1993. T cell-mediated induction of airway hyper-responsiveness and altered lung functions in mice are independent of increased vascular permeability and mononuclear cell infiltration. Am. Rev. Respir. Dis. 147 (2), 307–313.
27. Hedges, D.W., Reimherr, F.W., Strong, R.E., Halls, C.H., Rust, C., 1996. An open trial of nefazodone in adult patients with generalized anxiety disorder. Psychopharmacol. Bull. 32 (4), 671–676.
28. Hellstrand, K., Hermodsson, S., 1987. Role of serotonin in the regulation of human natural killer cell cytotoxicity. J. Immunol. 139, 869–875.
29. 1A receptors. Cell Immunol. 127, 199–214.
30. Irvin, J., Livnat, S., 1987. Behavioral influences on the immune system: stress and conditioning. Prog. Neuropsychopharmacol. Biol. Psychiatry 11, 137–143.
31. Jackson, J.C., Cross, R.J., Walker, R.F., Markesbery, W.R., Brooks, W.H., Roszman, T.L., 1985. Influence of serotonin on the immune response. Immunology 54, 505–512.
32. Keller, S.E., Schleifer, S.J., Camerino, M.A., Falini, J.A., Halperin, J., Stein, M., 1984. Stress-induced suppression of antibody production and PFCs in the rat. Psychosom. Med. 46, 286–293.
33. Kelley, K.W., Dantzer, R., 1991. Stress and immunity. In: Plotnikoff, N., Murgo, A., Faith, R., Wybran, J. (Eds.), Stress and Immunity, CRC Press, Boca Raton, FL, pp. 433–452.
34. Khansari, D.N., Murgo, A.J., Faith, R.E., 1990. Effects of stress on the immune system. Immunol. Tod. 11, 170–175.
35. Lader, M.H., 1996. Tolerability and safety: essentials in antidepressant pharmacotherapy. J. Clin. Psychiatry 57 (2), 39–44.
36. Matheson, G.K., Knowles, A., Guthrie, D., Gage, D., Weinzapfel, D., Blackbourne, J., 1997. Actions of serotonergic agents on hypo-thalamic–pituitary–adrenal axis activity in the rat. Gen. Pharmacol. 29 (5), 823–828.
37. Monjan, A.A., Collector, M.l., 1977. Stress-induced modulation of the immune response. Science 15, 307–308.
38. Morley, J.E., Kay, N.E., Solomon, G.F., Plotnikoff, N.P., 1987. Neuro-peptides: conductors of the immune orchestra. Life Sci. 41, 527–544.
39. Nunez, M.J., Riveiro, P., Varela, M. et al. Effects of nefazodone on delayed type hypersensitivity (DTH) response in stressed mice. Res. Commun. Psych. Psychiatry (in press).
40. Okimura, T., Ogawa, M., Yamauchi, T., 1986. Stress and immune responses Ill. Effect of restraint stress on delayed type hypersensitivity (DTH) response, natural killer (NK) activity and phagocytosis in mice. Jpn. J. Pharmacol. 41, 229–235.
41. Paegelow, I., Werner, H., Hagen, M., Wartner, U., Lange, P., 1985. Influence of serotonin on lymphokine secretion in vitro. Int. J. Immunopharmacol. 7, 889–896.
42. Qui-shi, L., Gui-zhen, Y., 1986. Influence of surgical stress on cellular immunity and the induction of plastic adherent suppressor cells of spleen in mice. Immunol. Invest. 15, 419–430.
43. Ramseier, H., Lichtensteiger, W., Schlumpf, M., 1993. In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen-and alloantigen-driven lymphocyte proliferation and on IL-I, IL-2 synthesis and IL-2 receptor expression. Immunopharmacol. Immunotoxicol. 15 (5), 557–582.
44. Riley, V., 1981. Psychoneuroendocrine influences on immunocompetence and neoplasia. Science 212, 1100–1109.
45. Schultz, R.M., Chirigos, M.A., Stoychkov, J.N., Pavlidis, N.A., 1979. Factors affecting macrophage cytotoxic activity with particular em-phasis on corticosteroids and acute stress. J. Reticuloendoth. Soc. 26, 83–92.
46. Shavit, Y., Terman, G.W., Martin, F.C., Lewis, J.W., Liebeskind, J.C., Gale, R.P., 1985. Stress, opioid peptides, the immune system and cancer. J. Immunol. 135, 834–837.
47. Steplewski, Z., Vogel, W.H., 1985. Changes in brain serotonin levels affect leukocytes, lymphocytes. T-cell subpopulations and natural killer cell activity. Neurosci. Lett. 62 (2), 277–282.
48. Steinberg, E.M., Wedner, H.J., Leung, M.K., Parker, C.W., 1987. Effect of serotonin (5-HT) and other monoamines on munne macrophages: modulation of interferon-T induced phagocytosis. J. Immunol. 138, 4360–4365.
49. Varela-Patino, M.P., Nunez, M.J., Losada, C. et al., 1994. Effects of alprazolam on delayed type hypersensitivity (DTH) response in stressed mice. Res. Commun. Psych. Psychiatry 19, 69–77.
50. Walsh, A.E., Cowen, P.J., 1994. Attenuation of the prolactin-stimulating and hyperthermic effects of nefazodone after subacute treatment. J. Clin. Psychopharmacol. 14 (4), 268–273.
51. Walsh, A.E., Hockney, R.A., Campling, G., Cowen, P.J., 1993. Neuroen-docrine and temperature effects of nefazodone in healthy volunteers. Biol. Psychiatry 33 (2), 115–119.
52. Weigent, D.A., Blalock, J.E., 1990. Immunoreactive growth hormone releasing hormone production by rat leukocytes. J. Neuroimmunol. 29, 1–13.
53. Yang, G.Z., Ma, T.H., 1988. Immunomodulatory effect of ginsenoside on cell-mediated immunity with operative stress in the mouse. Chung. Hsi. I. Chieh. Ho. Tsa. Chih. 8 (8), 479–480.
54. Zajecka, J.M., 1996. The effect of nefazodone on comorbid anxiety symptoms associated with depression: experience in family practice and psychiatric outpatient settings. J. Clin. Psychiatry 2, 10–14.
55. Zavala, F., 1997. Benzodiazepines, anxiety and immunity. Pharmacol. Ther. 75 (3), 199–216.