Local treatment of hepatic metastases with low-level direct electric current: Experimental results

Scandinavian Journal of Gastroenterology

Volumn 35, Issue 3, 2000, Pages 322-328

  Turler, Andreas ^a,b   Schaefer, H ^a   Schaefer, N ^a   Maintz, D ^a   Wagner, M ^a   Qiao, J C ^a   Hoelscher, A H ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Colorectal cancer; Electrolysis; Hepatic metastases; Low level direct current

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIRECT CURRENT; ELECTRIC CURRENT; ELECTRODE; ELECTROLYSIS; HISTOPATHOLOGY; LIVER METASTASIS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR VOLUME;

EID: 0034089246     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655200750024227     Document Type: Article

References (32)

1. 1. Schechter DC. Flashbacks: containment of tumors through electricity. Pacing Clin Electrophysiol 1979;2:100-14.
2. 2. Humphrey CE, Seal EH. Biophysical approach towards tumor regression in mice. Science 1959;130:388-9.
3. 3. Schauble MK, Habal MB, Gullick HD. Inhibition of experimental tumor growth in hamsters by small direct currents. Arch Pathol Lab Med 1977;101:294-7.
4. 4. Habal MB. Effect of applied dc currents on experimental tumor growth in rats. J Biomed Mater Res 1980;14:789-801.
5. 5. Marino AA, Morris D, Arnold T. Electrical treatment of Lewis lung carcinoma in mice. J Surg Res 1986;41:198-201.
6. 6. Morris DM, Marino AA, Gonzalez E. Electrochemical modification of tumor growth in mice. J Surg Res 1992;53:306-9.
7. 7. Nordenstrom BE. Biologically closed electric circuits: activation of vascular interstitial closed electric circuits for treatment of inoperable cancers. J Bioel 1984;3:137-53.
8. 8. Nordenstrom BE. Electrochemical treatment of cancer. I. Variable response to anodic and cathodic fields. Am J Clin Oncol 1989;12:530-6.
9. 9. Lao YH, Ge TG, Zheng XL, Zhang JZ, Hua YW, Mao SM, et al. Electrochemical therapy for intermediate and advanced liver cancer: a report of 50 cases. Eur J Surg 1994;Suppl:51-3.
10. 10. Quan K. Analysis of the clinical effectiveness of 144 cases of soft tissue and superficial malignant tumours treated with electrochemical therapy. Eur J Surg 1994;Suppl:37-40.
11. 11. Song Y, Li C, Li Y, Song Q, Chang B, Song L, et al. Electrochemical therapy in the treatment of malignant tumours on the body surface. Eur J Surg 1994;Suppl:41-3.
12. 12. Wang HL. Electrochemical therapy of 74 cases of liver cancer. Eur J Surg 1994;Suppl:55-7.
13. 13. Xin YL. Advances in the treatment of malignant tumours by electrochemical therapy (ECT). Eur J Surg 1994;Suppl:31-5.
14. 14. Xin YL. Organisation and spread of electrochemical therapy (ECT) in China. Eur J Surg 1994;Suppl:25-9.
15. 15. Turler A, Schafer H, Schafer N, Fischbach R, Wagner M. Qiao JC, et al. Pilot study about effectiveness of low-level direct current therapy in an experimental liver metastases model. Langenbecks Arch Chir 1998:Suppl 1:611.
16. 16. Qin Y, Van Cauteren M, Osteaux M, Willems G. Quantitative study of the growth of experimental hepatic tumors in rats by using magnetic resonance imaging. Int J Cancer 1992;51:665-70.
17. 17. Yamamoto J, Shimada K, Kosuge T, Yamasaki S, Sakamoto M, Fukuda H. Factors influencing survival of patients undergoing hepatectomy for colorectal metastases. Br J Surg 1999;86: 332-7.
18. 18. Doci R, Gennari L, Bignami P, Montalto F, Morabito A, Bozzetti F, et al. Morbidity and mortality after hepatic resection of metastases from colorectal cancer. Br J Surg 1995;82:377-81.
19. 19. Fuhrman CM, Curley SA, Hohn DC, Roh MS. Improved survival after resection of colorectal liver metastases. Ann Surg Oncol 1995;2:537-41.
20. 20. Vahrmeijer AL, van Dierendonck JH, van d V. Treatment of colorectal cancer metastases confined to the liver. Eur J Cancer 1995;3IA:1238-42.
21. 21. Bengmark S. Palliative treatment of hepatic tumours. Br J Surg 1989;76:771-3.
22. 22. Li K, Xin Y, Gu Y, Xu B, Fan D, Ni B. Effects of direct current on dog liver: possible mechanisms for tumor electrochemical treatment. Bioelectromagnetics 1997;18:2-7.
23. 23. Samuelsson L, Jonsson L. Electrolytic destruction of tissue in the normal lung of the pig. Acta Radiol Diagn (Stockh) 1981; 22:9-14.
24. 24. Samuelsson L, Jonsson L, Lamm IL, Linden CJ, Ewers SB. Electrolysis with different electrode materials and combined with irradiation for treatment of experimental rat tumors. Acta Radiol 1991;32:178-81.
25. 25. Nordenstrom BE. Survey of mechanisms in electrochemical treatment (ECT) of cancer. Eur J Surg 1994;Suppl:93-109.
26. 26. Baxter PS, Wemyss-Holden SA, Dennison AR, Maddern GJ. Electrochemically induced hepatic necrosis: the next step forward in patients with unresectable liver tumours? Aust N Z J Surg 1998;68:637-40.
27. 27. Griffin DT, Dodd NJ, Zhao S, Pullan BR, Moore JV. Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver. Br J Cancer 1995;72:31-4.
28. 28. Ito K, Ye CL, Kondou K, Akiyama S, Takagi H, Hirota H, et al. Treatment of solid tumor by a small amount of direct current. Can To Kagaku Ryoho 1995;22:1647-51.
29. 29. Griffin DT, Dodd NJ, Moore JV, Pullan BR, Taylor TV. The effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae. Br J Cancer 1994;69:875-8.
30. 30. Robertson GS, Wemyss-Holden SA, Dennison AR, Hall PM, Baxter P, Maddern GJ. Experimental study of electrolysis-induced hepatic necrosis. Br J Surg 1998;85:1212-6.
31. 31. Jaroszeski MJ, Gilbert RA, Heller R. In vivo antitumor effects of electrochemotherapy in a hepatoma model. Biochim Biophys Acta 1997;1334:15-8.
32. 32. Chou CK, McDougall JA, Ahn C, Vora N. Electrochemical treatment of mouse and rat fibrosarcomas with direct current. Bioelectromagnetics 1997;18:14-24.