Signalling pathways in vascular endothelium activated by shear stress: Relevance to atherosclerosis

Current Opinion in Lipidology

Volumn 11, Issue 2, 2000, Pages 167-177

  Resnick, Nitzan ^a   Yahav, Hava ^a   Schubert, Shay ^a   Wolfovitz, Efrat ^a   Shay, Ayelet ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; ION CHANNEL; NITRIC OXIDE; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE;

ATHEROSCLEROSIS; CELL ACTIVATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEMODYNAMICS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM;

ARTERIOSCLEROSIS; ENDOTHELIUM, VASCULAR; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034089197     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200004000-00010     Document Type: Review

References (100)

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99. 99 Davies PF, Polacek DC, Handen JS, Helmke BP, DePaola N. A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis. Trends Biotechnol 1999; 17:347-351. A novel approach for studying the differences in endothelial gene regulation by uniform or disturbed shear stresses is described. This experimental approach already suggests that many differences in the expression profile exist in between these two shear stress patterns.
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