Oxygen Free Radicals and the Effect of a Free Radical Scavenger in Patients with Intermittent Claudication

Vascular and Endovascular Surgery

Volumn 34, Issue 2, 2000, Pages 167-174

  Diamantopoulos, Emmanuel J ^a   Charitos, Dionisios ^b   Georgopoulos, Vassilios ^b   Economou, Emmanuel ^b   Sfakianakis, Michael ^c   Toutouzas, Pavlos ^b   Raptis, Sotirios ^b  

^a EVANGELISMOS HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c ATHENS UNIVERSITY OF ECONOMICS AND BUSINESS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

MALONALDEHYDE; OXYGEN RADICAL; SCAVENGER; TRIMETAZIDINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXERCISE; FEMALE; HUMAN; INTERMITTENT CLAUDICATION; MALE; OXIDATIVE STRESS; REPERFUSION INJURY;

EID: 0034088436     PISSN: 15385744     EISSN: None     Source Type: Journal    
DOI: 10.1177/153857440003400209     Document Type: Article

References (27)

1. McCord JM: Oxygen derived free radicals in postischemic tissue injury. N Engl J Med 312: 159-163, 1985.
2. Cross CE, Halliwell B., Borish ET, et al: Oxygen radicals and human disease. Ann Int Med 107: 526-545, 1987.
3. Halliwell B., Gutteridge JM: Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1-14, 1984.
4. Dean RT, Thomas SM, Garner A.: Free radical mediated fragmentation of monoamine oxidase in the mitochondrial membrane. Role of lipid radicals. Biochem J 240: 489-494, 1986.
5. Wade CR, van Rij A.: Plasma thiobarbituric acid reactivity: Reaction conditions and the role of iron, antioxidants and lipid peroxy radicals on the quantitation of plasma lipid peroxides. Life Sci 43: 1085-1093, 1988.
6. Gutteridge Jmc: The use of the standards for malondialdehyde. Anal Biochem 69: 518-526, 1975.
7. Hummel BW, Hummel BA, Mowbry A., et al: Reactive hyperemia vs treadmill exercise testing in arterial disease. Arch Surg 113: 95-98, 1978.
8. Quaife RA, Kohmoto O., Barry WH: Mechanisms of reoxygenation injury in cultured ventricular myocytes. Circulation 83: 566-577, 1991.
9. Lucchesi BR: Myocardial ischemia, reperfusion and free radical injury. Am J Cardiol 65: 141-231, 1990.
10. Garlick PB, Davies MJ, Hearse DJ, et al: Direct detection of free radicals in the reperfused heart using electron spin resonance spectroscopy. Circ Res 61: 757-760, 1987.
11. Suzuki S., Kaneco M., Chapman DC, et al: Alterations in cardiac contractile proteins due to oxygen free radicals. Biochim Biophys Acta 1074: 95-100, 1991.
12. Geeraerts MD, Ronveaux-Dupal MF, Lemasters JJ, et al: Cytosolic free Ca++ and proteolysis in lethal oxidative injury in endothelial cells. Am J Physiol 261:C 889-C 896, 1991.
13. Ohman EM, Califf RM, Topol EJ, et al: Consequences of reocclusion after successful reperfusion therapy in acute myocardial infarction. TAMI Study Group. Circulation 82: 781-791, 1990.
14. Bolli R.: Mechanism of myocardial “stunning.” Circulation 82: 723-738, 1990.
15. Salminen A., Vihko V.: Lipid peroxidation in exercise myopathy. Exp Mol Pathol 38: 380-388, 1983.
16. Kober G., Buck T., Sievert H., et al: Myocardial protection during percutaneous transluminal coronary angioplasty: Effects of trimetazidine. Eur Heart J 13: 1109-1115, 1992.
17. Fabiani JN, Ponzio O., Emerit I., et al: Cardioprotective effect of trimetazidine during coronary artery graft surgery. J Cardiovasc Surg 33: 486-491, 1992.
18. Sellier P., Audouin P., Payen B., et al: Ergometric effects of a single administration of trimetazidine. Presse Med 15: 1771-1774, 1986.
19. Belcher P., Drake-Holland AJ, et al: Trimetazidine reduces myocardial infarct size, relative area at risk, after temporary coronary artery occlusion in the rabbit. Br J Pharmacol 107:265P, 1992.
20. Boucher F., Hearse DJ, Opie L.: Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts. J Cardiovasc Pharmacol 24: 45-49, 1994.
21. Harpey C., Clauser P., Labrid C., et al: Trimetazidine, a cellular anti-ischemic agent. Cardiovasc Drug Rev 6: 292-312, 1989.
22. Maridonneau-Parini K., Harpey C.: Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Br J Clin Pharmacol 20: 148-151, 1985.
23. Ruiz-Meana M., Garcia-Dorado D., Julia M., et al: Pretreatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes. Cardiovasc Res 32: 587-592, 1996.
24. Weiss T., Fujita Y., Kreimeier U., et al: Effect of intensive walking exercise on skeletal muscle blood flow in intermittent claudication. Angiology 43: 63-71, 1992.
25. Clement DL: Occlusive arterial disease in the lower limbs: Physiologic principles and guidelines to methods of investigation and treatment. Int Angiol 3: 57-65, 1984.
26. Witzum JL: The oxidation hypothesis of atherosclerosis. Lancet 344: 793-795, 1994.
27. Bastounis E., Hadjinikolaou L., Pikoulis M., et al: Free radical related myocardial mitochondrial damage following limb ischemia-reperfusion. Cardiovasc Res 28: 1868-1871, 1994.