Cetirizine and loratadine: A comparison using the ED50 in skin reactions

Journal of International Medical Research

Volumn 28, Issue 2, 2000, Pages 69-77

  Ramboer, I ^a   Bumbacea, R ^b   Lazarescu, D ^b   Radu, J R ^b  

^a UCB PHARMA   (Belgium)

^b 'N Malaxa' Hospital   (Romania)

Author keywords

Antihistamines; Cetirizine; ED50; Histamine prick test; Loratadine; Skin reactions

Indexed keywords

CETIRIZINE; HISTAMINE; LORATADINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG POTENCY; FEMALE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; URTICARIA;

ADULT; CETIRIZINE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HISTAMINE; HISTAMINE H1 ANTAGONISTS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LORATADINE; SKIN; SKIN TESTS;

EID: 0034088223     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000002800202     Document Type: Article

References (11)

1. 1 inhibiting effects of cetirizine 2HCl and loratadine. Ann Allergy 1990; 65: 139-142.
2. Poulsen LK, Bindler-Jensen C, Rihoux JP: Qualitative determination of skin reactivity by two semi automatic devices for skin prick test area measurements. Agents Actions 1994; 41: C134-C135.
3. Simons FER, McMillan JL, Simons KJ: A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 h in normal subjects. J Allergy Clin Immunol 1990; 86: 540-547.
4. Grant JA, Danielson L, Rihoux J-P, et al: A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression effects of histamine-induced wheal and flare response during 24 h in healthy male subjects. Allergy 1999; 54: 700-707.
5. Persi L, Demoly P, Harrias A, et al: Comparison between nasal provocation tests and skin tests in patients treated with loratadine and cetirizine. J Allergy Clin Immunol 1999; 103: 591-594.
6. Humphreys F, Hunter JAA: The effects of astemizole, cetirizine and loratadine on the time course of weal and flare reactions to histamine, codeine and antigen. Br J Dermatol 1991; 125: 364-367.
7. Fadel R, Herpin-Richard N, Dufresne F, et al: Pharmacological modulation by cetirizine and loratadine of antigen and histamine-induced skin weals and flares, and late accumulation of eosinophils. J Int Med Res 1990; 18: 366-371.
8. Coulie P, de Vos C, Ghys L, et al: Pharmacologic modulation by cetirizine 2 HCl and loratadine of the histamine-induced skin reaction in mice and in humans. Drug Dev Res 1989; 17: 199-206.
9. Kontou Fili K, Paleologos G, Herakleous M: Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCL. Eur J Clin Pharmacol 1989; 36: 617-619.
10. 1-receptor antagonists as assessed by the induced wheal and flare model. Allergy 1995; 50 (Suppl 24): 24-30.
11. Lever LR, Hill S, Marks R et al: Effects of cetirizine, loratadine and terfenadine on histamine weal and flare reactions. Skin Pharmacol 1992; 5: 29-33.