1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death

Cancer Research

Volumn 60, Issue 7, 2000, Pages 2040-2048

  Wang, Qin ^a   Yang, Wen ^a   Uytingco, Myrna S ^a   Christakos, Sylvia ^a   Wieder, Robert ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; DOXORUBICIN; ESTROGEN RECEPTOR; PACLITAXEL; PROTEIN BCL 2; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; VITAMIN D RECEPTOR;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SENSITIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CALCITRIOL; CELL SURVIVAL; DOXORUBICIN; DRUG SYNERGISM; FEMALE; HUMANS; PACLITAXEL; RECEPTORS, CALCITRIOL; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0034086039     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Garber, J. E., and Henderson, I. C. The use of chemotherapy in metaslatic breast cancer. Hematol. Oncol. Clin. N. Am., 3: 807-821, 1989.
2. Norton, L. Evolving concepts in the systemic drug therapy of breast cancer. Semin. Oncol., 24: S10-3-S10-10, 1997.
3. 3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines. Cancer Res., 55: 2822-2830, 1995.
4. 3 derivatives and breast tumor cell growth: effect on intracellular calcium and apoptosis. Int. J. Cancer, 61: 806-811, 1995.
5. Welsh, J. Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens. Biochem. Cell Biol., 72: 537-545, 1994.
6. 1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene, 11: 493-504, 1995.
7. Liu, Y., Lee, M-O., Wang, H-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J. C., and Zhang, X-K. Retinoic acid receptor β mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol. Cell. Biol., 16: 1138-1149, 1996.
8. Rubin, M., Fenig, E., Rosenauer, A., Menendez-Botet, C., Achkar, C., Bentel, J. M., Yahalom, J., Mendelsohn, J., and Miller, W. H., Jr. 9-cis retinoic acid inhibits growth of breast cancer cell and down-regulates estrogen receptor RNA and protein. Cancer Res., 54: 6549-6556, 1994.
9. Green, S., and Chambon, P. Nuclear receptors enhance our understanding of transcription regulation. Trends Genet., 4: 309-314, 1988.
10. 3 leads to induced differentiation of the myelomonocytic cell line U937. Genes Dev., 10: 142-153, 1996.
11. WAF1/CIP1 gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. J. Biol. Chem., 271: 31723-31728, 1996.
12. 3 in HL60 cells. Cancer Res., 56: 264-267, 1996.
13. 3-treated HL60 cells. Cancer Res., 57: 2851-2855, 1997.
14. Zhou, Q., Stetler-Stevenson, M., and Steeg, P. S. Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro. Oncogene, 15: 107-115, 1997.
15. 3-resistant variant. Endocrinology, 138: 4690-4698, 1997.
16. Zhu, W-Y., Jones, C. S., Kiss, A., Matsukuma, K., Amin, S., and DeLuca, L. M. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp. Cell Res., 234: 293-299, 1997.
17. Toma, S., Isnardi, L., Riccardi, L., and Bollag, W. Induction of apoptosis in MCF-7 breast carcinoma cell line by RAR and RXR selective retinoids. Anticancer Res., 18: 935-942, 1998.
18. 3 combined with retinoic acid or dexamethasone. Anticancer Drugs, 6: 562-569, 1995.
19. 1. Endocrinology, 138: 1491-1497, 1997.
20. James, S. Y., Mackay, A. G., and Colston, K. W. Vitamin D derivatives in combination with 9-cis retinoic acid promote active cell death in breast cancer cells. J. Mol. Endocrinol., 14: 391-394, 1995.
21. 3 and retinoic acid (all trans and 9 cis) on proliferation, differentiation, and programmed cell death in two small cell lung carcinoma cell lines. Biochem. Biophys. Res. Commun., 249: 735-744, 1998.
22. Zhang, X. K., Hoffmann, B., Tran, P. B., Graupner, G., and Pfahl, M. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (Lond.), 355: 441-446, 1992.
23. 3 signalling. Nature (Lond.), 355: 446-449, 1992.
24. Yu, V. C., Delsert, C., Andersen, B., Holloway, J. M., Devary, O. V., Naar, A. M., Kim, S. Y., Boutin, J. M., Glass, C. K., and Rosenfeld. M. G. RXR β: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell, 67: 1251-1266, 1991.
25. Schrader, M., Bendik, I., Becker-Andre, M., and Carlberg, C. Interaction between retinoic acid and vitamin D signalling pathways. J. Biol. Chem., 268: 17830-17836, 1993.
26. Maloof, P., Wang, Q., Wang, H., Stein, D., Denny, T. N., Yahalom, J., Fenig, E., and Wieder, R. Overexpression of retrovirally transduced basic FGF in MCF-7 human breast cancer cells down-regulates Bcl-2 and sensitizes cells to chemotherapy-induced apoptosis. Breast Cancer Res. Treat., 56: 153-167, 1999.
27. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 762: 156-159, 1987.
28. Lehtola, L., Partanen, J., Sistonen, L., Korhonen, J., Warri, A., Harkonen, P., Clarke, R., and Alitalo, K. Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast cancer cells. Int. J. Cancer, 50: 598-603, 1992.
29. Fenig, E., Wieder, R., Paglin, S., Wang, H., Persaud, R., Haimovitz-Friedman, A., Fuks, Z., and Yahalom, J. Basic fibroblast growth factor confers growth inhibition and mitogen-activated protein kinase activation in human breast cancer cells. Clin. Cancer Res., 3: 135-142, 1997.
30. Wang, Q., Maloof, P., Wang, H., Fenig, E., Stein, D., Nichols, G., Denny, T. N., Yahalom, J., and Wieder, R. Basic fibroblast growth factor (bFGF) down-regulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. Exp. Cell Res., 238: 177-187, 1998.
31. Loewe, S., and Muischnek, H. Effect of combinations: mathematical basis of problem. Arch. Exp. Pathol. Pharmakol., 114: 313-326, 1926.
32. Naguib, M., Samarkandi, A. H., Ammar, A., and Al-Zahrani, S. Comparative clinical pharmacology of rocuronium, cisatracurium and their combination. Anesthesiology, 89: 1116-1124, 1998.
33. Greco, W. R., Bravo, G., and Parsons, J. C. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev., 47: 331-385, 1995.
34. Schiff, P. B., and Horwitz, S. B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA, 77: 1561-1565, 1980.
35. Blagosklonny, M. V., Schulte, T., Nguyen, P., Trepel, J., and Neckers, L. M. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res., 50: 1851-1854, 1996.
36. 2-terminal kinase (JNK/SAPK). J. Biol. Chem., 273: 28253-28260, 1998.
37. 3 in normal human keratinocytes. J. Investig. Dermatol., 106: 1212-1217, 1996.
38. Yen, A., Roberson, M. S., Varvayanis, S., and Lee, A. T. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res., 58: 3163-3172, 1988.
39. Dawson, M. I., Chao, W-R., Pine, P., Jong, L., Hobbs, P. D., Rudd, C. K., Quick, T. C., Niles, R. M., Zhang, X-K., Lombardo, A., Ely, K. R., Shroot, B., and Fontana, J. A. Correlation of retinoid binding affinity to retinoic acid receptor a with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells. Cancer Res., 55: 4446-4451, 1995.
40. van der Leede, B-M., Folkers, G. E., van den Brink, C. E., van der Saag, P. T., and van der Burg, B. Retinoic acid receptor α 1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells. Mol. Cell. Endocrinol., 109: 77-86, 1995.
41. Light, B. J., Yu, W-D., McElwain, M. C., Russell, D. M., Trump, D. L., and Johnson, C. S. Potentiation of cisplatin tumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res., 57: 3759-3764, 1997.
42. Haldar, S., Jena, N., and Croce, C. M. Inactivation of Bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. USA, 92: 4507-4511, 1995.
43. Blagosklonny, M. V., and Fojo, T. Molecular effects of paclitaxel: myths and reality-a critical review. Int. J. Cancer, 83: 151-156, 1999.