QSAR studies of compounds acting by polar and non-polar narcosis: An examination of the role of polarisability and hydrogen bonding

Quantitative Structure-Activity Relationships

Volumn 19, Issue 1, 2000, Pages 3-9

  Dearden, J C ^a   Cronin, M T D ^a   Zhao, Y H ^b   Raevsky, O A ^c  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

Hydrogen bonding; Log P; Polarisability; Toxicity

Indexed keywords

COMPLEXATION; COMPUTATIONAL CHEMISTRY; FREE ENERGY; POLARIZATION; TOXICITY;

DIFFERENT MECHANISMS; HYDROGEN BOND ACCEPTORS; LOG P; NON-POLAR; OCTANOL-WATER PARTITION COEFFICIENT; POLAR NARCOTICS; POLARISABILITIES; QSAR STUDIES;

HYDROGEN BONDS;

ACETONE; ANILINE DERIVATIVE; BROMOBENZENE; CHLOROBENZENE; CHLOROFORM; CYCLOHEXANE; CYCLOHEXANONE; DICHLOROETHANE; HEXACHLOROBENZENE; HEXANE; NARCOTIC AGENT; OCTANOL; PHENOL DERIVATIVE; RESORCINOL; TETRACHLOROETHANE; TETRAHYDROFURAN; TOLUENE; XYLENE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HYDROGEN BOND; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TOXICITY; TOXICITY TESTING;

EID: 0034085367     PISSN: 09318771     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3838(200002)19:1<3::AID-QSAR3>3.0.CO;2-N     Document Type: Article

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