Acute exposure to saccharin reduces morphine analgesia in the rat: Evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors

Psychopharmacology

Volumn 149, Issue 1, 2000, Pages 56-62

  McNally, G P ^a   Westbrook, R F ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Morphine; NMDA; Opioid receptor; Rat; Tail flick; Tolerance

Indexed keywords

DIZOCILPINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SACCHARIN;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SWEETNESS;

ANALGESIA; ANALGESICS, OPIOID; ANIMALS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; PAIN; PAIN MEASUREMENT; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, OPIOID; SACCHARIN; SWEETENING AGENTS;

EID: 0034082788     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002139900337     Document Type: Article

References (24)

1. Bechara A, van der Kooy D (1985) Opposite motivational effects of endogenous opioids in the brain and periphery. Nature 314:533-534
2. Bechara A, Zito KA, van der Kooy D (1987) Peripheral receptors mediate the aversive effects of morphine in the rat. Pharmacol Biochem Behav 28:219-225
3. Berge OG, Garcia-Cabrera I, Hole K (1988) Response latencies in the tailflick test depend on tailskin temperature. Neurosci Lett 86:284-288
4. Bergmann F, Lieblich I, Cohen E, Ganchrow JR (1985) Influence of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats. Behav Neural Biol 44:347-353
5. Bevins RA, Delzer TA, Bardo MT (1996) Second-order conditioning detects unexpressed morphine-induced salt aversion. Anim Learning Behav 24:221-229
6. Cappell H, LeBlanc AE (1975) Conditioned aversion by psychoactive drugs: does it have any significance for an understanding of drug dependence? Addict Behav 1:55-64
7. D'Anci KE, Kanarek RB, Marks-Kaufmann R (1997) Beyond sweet: saccharin, sucrose, and polycose differ in their effects upon morphine analgesia. Pharmacol Biochem Behav 56:341-345
8. Dum J, Gramsch C, Herz A (1983) Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food. Pharmacol Biochem Behav 18:443-447
9. Fidler P, Kalman BA, Zeimer HE, Green KF (1993) Early-onset of reduced morphine analgesia by ingestion of sweet solutions. Physiol Behav 53:167-171
10. Harris RJ (1994) Analysis of variance primer. F.E. Peacock, Illinois
11. Hays WL (1972) Statistics for the social sciences. Holt, Rhine-Hart, and Wilson, New York
12. Holder MD, Bolger GT (1988) Chronic sweet intake lowers pain thresholds without changing brain mu-or delta opiate receptors. Behav Neural Biol 50:45-53
13. Hunt T, Amit Z (1987) Conditioned taste aversion induced by self-administered drugs: paradox revisited. Neurosci Biobehav Rev 11:107-130
14. Kanarek RB, White ES, Biegen MT, Marks-Kaufman R (1991) Dietary influences on morphine-induced analgesia in rats. Pharmacol Biochem Behav 38:681-684
15. Klein SP, Green KF (1988) Tolerance to morphine analgesia from brief exposure to a palatable solution. Brain Res Bull 21:963-965
16. Lieblich I, Cohen E, Ganchrow JR, Blass EM, Bergmann F (1983) Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake. Science 221:871-873
17. Mackintosh NJ (1983) Conditioning and associative learning. Oxford University Press, New York
18. McNally GP (1999) Pain facilitatory circuits in the mammalian central nervous system: their behavioral significance and role in morphine analgesic tolerance. Neurosci Biobehav Rev 23:1059-1078
19. McNally GP, Westbrook RF (1998) Effects of systemic, intracerebral, or intrathecal administration of an N-methyl-d-aspartate receptor antagonist on associatively-mediated morphine analgesic tolerance and hyperalgesia in rats. Behav Neurosci 114:652-664
20. Mao J, Price DD, Mayer DJ (1995) Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62:259-274
21. Revusky S (1971) The role of interference in association over a delay. In: Honig WK, James PHR (eds) Animal memory. Academic Press, New York, pp 155-213
22. Russell J, Bass P, Goldberg LI, Schuster CR, Merz H (1982) Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists. Eur J Pharmacol 78:255-261
23. Trujillo KA, Akil H (1991) Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251:86-87
24. Watkins LR, Wiertelak EP, Goehler LE, Mooney-Heiberger K, Martinez J, Furness L, Smith KP, Maier SF (1994) Neurocircuitry of illness-induced hyperalgesia. Brain Res 639:283-299