Statistical comparison of high-shear versus low-shear granulation using a common formulation

Drug Development and Industrial Pharmacy

Volumn 26, Issue 3, 2000, Pages 357-364

  Shiromani, P K ^a   Clair, J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Granulation mixer; Optimization

Indexed keywords

CALCIUM PHOSPHATE; MAGNESIUM STEARATE; MANNITOL; STARCH;

ARTICLE; CORRELATION FUNCTION; DRUG GRANULATION; DRUG MIXTURE; DRUG SOLUBILITY; GELATINIZATION; PRINCIPAL COMPONENT ANALYSIS; SHEAR RATE; STATISTICAL ANALYSIS; TABLET COMPRESSION; TABLET FORMULATION; TABLET PROPERTY;

CHEMISTRY, PHARMACEUTICAL; MATHEMATICAL COMPUTING; SOLUBILITY; TABLETS;

EID: 0034082625     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100100365     Document Type: Article

References (9)

1. E. M. Scattergood, J. B. Schwartz, M. O. Villarejos, W. J. McAleer, and M. R. Hilleman, Drug Dev. Ind. Pharm., 9, 745 (1983).
2. M. L. Cotton and G. R. B. Down, J. Chromatogr., 259, 17 (1983).
3. D. A. Doombos, Pharm. Wkbld. (Sci. Ed.), 3, 549 (1981).
4. J. B. Schwartz, J. Soc. Cosmet. Chem., 32, 287 (1981).
5. J. B. Schwartz, J. R. Flamholz, and R. H. Press, J. Pharm. Sci., 62, 1518 (1973).
6. J. B. Schwartz, J. R. Flamholz, and R. H. Press, J. Pharm. Sci., 62, 1518 (1973).
7. G. R. B. Down, R. A. Miller, S. K. Chopra, and J. F. Miller, Drug Dev. Ind. Pharm., 6, 311 (1980).
8. N. R. Bohidar, J. F. Bavitz, and P. K. Shiromani, Drug Dev. Ind. Pharm., 12, 1503 (1986).
9. T. Schofield, J. F. Bavitz, C. M. Lei, L. Oppenheimer, and P. K. Shiromani, Drug Dev. Ind. Pharm., 17, 959 (1991).