N6-2-(4-Aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats

European Neuropsychopharmacology

Volumn 10, Issue 4, 2000, Pages 237-243

  Borowicz, Kinga K ^a   Kleinrok, Zdzisław ^a   Czuczwar, Stanisław J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Adenosine receptor; Antiepileptic drugs; APNEA; Kindling; Seizure

Indexed keywords

6 N [2 (4 AMINOPHENYL)ETHYL]ADENOSINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLONAZEPAM; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; KINDLING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

EID: 0034082506     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(00)00081-X     Document Type: Article

References (36)

1. R.A. Barraco T.H. Swanson J.W. Phillis R.F. Berman Anticonvulsant effects of adenosine analogues on amygdaloid-kindled seizures in rats Neurosci. Lett. 18 1984 317 322
2. A.S. Bender L. Hertz Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures Neurochem. Res. 11 1986 1507 1524
3. 6-2-(4-Aminophenyl)ethyl-adenosine enhances the anticonvulsive activity of antiepileptic drugs Eur. J. Pharmacol. 327 1997 125 133
4. K.K. Borowicz P. Wilczyński Z. Kleinrok S.J. Czuczwar Influence of aminophylline on the protective activity of carbamazepine against amygdala-kindled seizures in rats Pol. J. Pharmacol. 50 1998 90 91
5. E.A. Cavalheiro L.S. Calderazzo Filho Z.A. Bortolotto L. Mello L. Turski Anticonvulsant role of adenosine Pol. J. Pharmacol. Pharm. 39 1987 537 543
6. J.H. Chin Adenosine receptors in brain: neuromodulation and role in epilepsy Ann. Neurol. 26 1989 695 698
7. S.J. Czuczwar W.A. Turski C. Ikonomidou L. Turski Aminophylline and CGS 8216 reverse the protective action of diazepam against electroconvulsions in mice Epilepsia 26 1985 693 696
8. S.J. Czuczwar C. Ikonomidou Z. Kleinrok L. Turski W.A. Turski Effect of aminophylline on the protective action of common antiepileptic drugs against electroconvulsions in mice Epilepsia 27 1986 204 208
9. S.J. Czuczwar R. Jäckel W. Löscher Effects of aminophylline and enprofylline on the protective activity of phenobarbital against amygdala-kindled seizures in rats Epilepsy Res. 1 1987 234 238
10. S.J. Czuczwar W. Janusz B. Szczepanik A. Wamil Z. Kleinrok Effect of aminophylline upon the protective activity of common antiepileptic drugs and their plasma levels in mice Neurosci. Res. 6 1989 470 474
11. S.J. Czuczwar B. Szczepanik A. Wamil W. Janusz Z. Kleinrok Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice J. Neural. Transm. 81 1990 153 166
12. S.J. Czuczwar W. Janusz B. Szczepanik Z. Kleinrok Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice J. Neural Transm. 86 1991 127 134
13. M. Dragunow Adenosine and epileptic seizures J.W. Phillis Adenosine and Adenine Nucleotides as Regulators of Cellular Functions 1991 CRC Press Boca Raton, FL 367 376
14. M. Dragunow G.V. Goddard Adenosine modulation of amygdala kindling Exp. Neurol. 84 1984 654 665
15. N.W. Dunham T.S. Miya A note on a simple approach for determining neurological deficits in rats and mice J. Am. Pharmacol. Assoc. 46 1957 208
16. M.J. During D.P. Spencer Adenosine: a potential mediator of seizure arrest and postictal refractoriness Ann. Neurol. 32 1992 618 624
17. E. Fifková J. Marsala Stereotaxic atlases for the cat, rabbit and rat J. Bureš M. Petran J. Zachar Electrophysiological Methods in Biological Research 1967 Academic Press New York 653 695
18. 3 mediate hypotension in the angiotensin II supported circulation of the pitched rat Br. J. Pharmacol. 109 1993 3 5
19. 2) receptors Psychopharmacology 90 1986 332 335
20. 3 adenosine receptors: mediation of behavioral depressant effects FEBS Lett. 336 1993 57 63
21. 3 adenosine receptors: design of selective ligands and therapeutic prospects Drugs Future 20 1995 689 699
22. 3 receptors: pharmacological properties, species differences and receptor functions Trends Pharmacol. Sci. 15 1994 298 304
23. W. Löscher D. Schmidt Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations Epilepsy Res. 2 1988 145 181
24. P.J. Marangos L. Miller Adenosine-based therapeutics in neurologic disease J.W. Phillis Adenosine and Adenine Nucleotides as Regulators of Cellular Function 1991 CRC Press Boca Raton, FL 413 422
25. P.J. Marangos S.R.B. Weiss P. Montgomery J. Patel P.K. Narang A.M. Cappabianca R.M. Post Chronic carbamazepine treatment increases brain adenosine receptors Epilepsia 26 1985 493 498
26. J.W. Phillis Interactions of the anticonvulsants diphenylhydantoin and carbamazepine with adenosine on cerebral cortical neurons Epilepsia 25 1984 765 772
27. J.W. Phillis P.H. Wu The effect of various centrally active drugs on adenosine uptake by the central nervous system Comp. Biochem. Physiol. 72c 1982 179 187
28. R.J. Racine Modification of seizure activity by electrical stimulation. II. Motor seizure Electroencephalogr. Clin. Neurophysiol. 32 1972 281 294
29. J.B. Rosen R.F. Berman Differential effects of adenosine analogs on amygdala, hippocampus, and caudate nucleus kindled seizures Epilepsia 28 1987 658 666
30. J.H. Skerrit G.A.R. Johnston S. Chen Chow Interaction of the anticonvulsant carbamazepine with adenosine receptors. 2. Pharmacological studies Epilepsia 24 1983 643 650
31. 3 receptor stimulation on seizures in mice Eur. J. Pharmacol. 275 1995 23 29
32. P. Venault G. Chapoutier L.P. De Carvalho J. Simiand M. Morre R.H. Dodd J. Rossier Benzodiazepines impair and betacarbolines enhance performance in learning and memory tasks Nature 321 1986 864 866
33. R.L. Weir W. Padgett J.W. Daly S.M. Anderson Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system Epilepsia 25 1984 492 498
34. P. Wilczyński K.K. Borowicz Z. Kleinrok S.J. Czuczwar Aminophylline and the anticonvulsive action of valproate against amygdala-kindled seizures in rats Pol. J. Pharmacol. 50 1998 91 92
35. D. Young M. Dragunow Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms Neuroscience 58 1994 245 261
36. M.R. Zarrindast S. Bijan Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning Eur. J. Pharmacol. 256 1994 233 239