Synthesis of 1-[2-[18F]Fluoro-1-(hydroxymethyl)-ethoxy]methyl-2-nitroimidazole ([18F]FENI), a potential agent for imaging hypoxic tissues by PET

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 43, Issue 8, 2000, Pages 785-793

  Wada, Hiroaki ^a   Iwata, Ren ^a   Ido, Tatsuo ^a   Takai, Yoshihiro ^b  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

1 2 fluoro 1 (hydroxymethyl)ethoxyl ; FENI; Fluorine 18; Hypoxic cell marker; PET; Tumor imaging

Indexed keywords

FLUORINE; TISSUE;

1-[2-FLUORO-1-(HYDROXYMETHYL)ETHOXYL]; CELL MARKERS; FENI; FLUORINE-18; HYPOXIC CELL MARKER; HYPOXIC CELLS; HYPOXIC TISSUES; NITROIMIDAZOLES; SYNTHESISED; TUMOR IMAGING; 1-[2-FLUORO-1-(HYDROXYMETHYL)ETHOXY]METHYL-2-NITROIMIDAZOLE;

METHANOL;

1 [2 FLUORO 1 (HYDROXYMETHYL)ETHOXY] METHYL 2 NITROIMIDAZOLE; FLUORINE 18; NITROIMIDAZOLE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXEMIA; POSITRON EMISSION TOMOGRAPHY;

EOS;

EID: 0034081947     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1344(200007)43:8<785::AID-JLCR363>3.0.CO;2-5     Document Type: Article

References (14)

1. Jerabek P.A, Patrick T.B., Kilbourn M.R., Dischino D.D., Welch M.J. Appl. Radiat. Isot. 37: 599-605 (1986).
2. Grierson J.R., Link J.M., Mathis C.A., Rasey J.S., Krohn K.A. J. Nucl. Med. 30: 343-350 (1989).
3. Lim J.-L., Berridge M.S. Appl. Radiat. Isot. 44: 1085-1091 (1993).
4. McCarthy T.J., Dence C.S., Welch M.J. Appl. Radiat. Isot. 44: 1129-1132 (1993).
5. Tada M., Iwata R., Sugiyama H. et al. J. Labelled Cpd. Radiopharm. 38: 771-774 (1996).
6. Nunn A., Linder K., Strauss H.W. Eur. J. Nucl. Med. 22: 265-280 (1995).
7. Tewson T.J. Nucl. Med. Biol. 24: 755-760 (1997).
8. Kachur A.V., Dolbier W.R., Evans S.M. et al. Appl. Radiat. Isot. 51: 643-650 (1999).
9. Murayama C., Suzuki A., Suzuki T., Miyata Y., Sakaguchi M., Tanabe Y., Tanaka N., Mori T. J. Radiation Oncology Biol. Phys. 17: 575-581 (1989).
10. Sasai K., Shibamoto Y., Takahashi M., Abe M., Wang J., Zhou L., Nishimoto S., Kagiya T. Jpn. J. Cancer Res. 80: 1113-1118 (1989).
11. Murayama C., Suzuki A., Sato C., Tanabe Y., Miyata Y., Shoji T., Suzuki T., Sakaguchi M., Mori T. Int. J. Radiation Oncology Biol. Phys. 22: 557-560 (1991).
12. Aragozzini F., Maconi E., Potenza D., Scolastico C. Synthesis 1989: 225-227 (1989).
13. Martin J.C., McGee D.P.C., Jeffrey G.A., Hobbs D.W., Smee D.F., Matthews T.R., Verheyden J.P.H. J. Med. Chem. 29: 1384-1384 (1986).
14. Alauddin M.M., Conti P.S. Nuc. Med. Bio. 25: 175-180 (1998).