Evidence that non-deletional mechanisms are responsible for inducing and maintaining unresponsiveness after intrathymic injection of non-professional antigen presenting cells

Journal of Heart and Lung Transplantation

Volumn 19, Issue 6, 2000, Pages 576-583

  Niimi, Masanori ^a   Jones, Nick D ^a   Morris, Peter J ^a   Wood, Kathryn J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL TRANSFER; CONTROLLED STUDY; DENDRITIC CELL; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; THYMUS;

ANIMALS; ANTIGEN-PRESENTING CELLS; AUTOANTIBODIES; CELL TRANSPLANTATION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS; ISOANTIGENS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; SPLEEN; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS;

EID: 0034081917     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-2498(00)00099-1     Document Type: Article

References (32)

1. von Boehmer H. Positive selection of lymphocytes. Cell. 76:1994;219-228.
2. Nossal N. Negative selection of lymphocytes. Cell. 76:1994;229-239.
3. Staples P., Gery I., Waksman B. Role of the thymus in tolerance. Tolerance to bovine gamma globulin after direct injection of antigen into the shielded thymus of irradiated rats. J Exp Med. 124:1966;127-139.
4. Vojtiskova M., Lengerova A. Thymus-mediated tolerance to cellular alloantigens. Transplantation. 6:1968;13-24.
5. Posselt A.M., Barker C.F., Tomaszewski J.E., Markmann J.F., Choti M.A., Naji A. Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science. 249:1990;1293-1295.
6. Goss J.A., Nakafusa Y., Flye M.W. MHC class II presenting cells are necessary for the induction of intrathymic tolerance. Ann Surg. 217:1993;492-499.
7. Oluwole S.F., Chowdhury N.C., Fawwaz R.A. Induction of donor-specific unresponsiveness to rat cardiac allografts by pre-treatment with intrathymic donor MHC class I antigens. Transplantation. 55:1993;1396-1402.
8. Knechtle S.J., Wang J., Jiao S., Geissler E.K., Sumitomo R., Wolff J. Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class 1 major histocompatibility complex. Transplantation. 57:1994;990-996.
9. Remuzzi G., Rossini M., Imberti O., Perico N. Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation. (see comments) Lancet. 337:1991;750-752.
10. Goss J.A., Nakafusa Y., Yu S., Flye M.W. Intrathymic injection of donor alloantigens induces specific tolerance to cardiac allografts. Transplantation. 56:1993;166-173.
11. Kappler J.W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell. 49:1987;273-280.
12. + thymocytes. Nature. 333:1988;742-746.
13. α-encoded antigens. Nature. 332:1988;40-45.
14. Ramsdell F., Lantz T., Fowlkes B.J. A nondeletional mechanism of thymic self tolerance. Science. 246:1989;1038-1041.
15. Husbands S.D., Schonrich G., Arnold B., et al. Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via non-deletional mechanism. Eur J Immunol. 22:1992;2655-2661.
16. Schonrich G., Momburg F., Hammerling G., Arnold B. Anergy induced by thymic medullary epithelium. Eur J Immunol. 22:1992;1687-1691.
17. Jones N.D., Fluck N.C., Roelen D.L., Mellor A.L., Morris P.J., Wood K.J. Deletion of alloantigen reactive thymocytes as a mechanism of adult tolerance induction following intrathymic antigen administration. Eur J Immunol. 27:1997;1591-1600.
18. Gillanders W., Arima T., Tu F., Hansen T., Flye M. Evidence for clonal deletion and clonal anergy after intrathymic antigen injection in a transplantation model. Transplantation. 64:1997;1159-1166.
19. Niimi M, Jones ND, Pajaro OE, Morris PJ , Wood KJ. Intrathymic administration of B cells induces prolonged survival of fully allogeneic cardiac grafts without prolonged deletion of donor specific thymocytes. Transplant immunol 1998;(in press).
20. Niimi M., Roelen D.L., Wong W., Hara M., Morris P.J., Wood K.J. Resting B cells as tolerogens in vivo but only for minor histocompatibility antigens. Transplantation. 64:1997;1330-1335.
21. Cobbold S.P., Martin G., Qin S., Waldmann H. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature. 323:1986;164-166.
22. Nussenzweig M.C., Steinman R.M. Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J Exp Med. 151:1980;1196-1212.
23. Cobbold S.P., Jayasuriya A., Nash A., Prospero T.D., Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature. 312:1984;548-551.
24. Corry R.J., Winn H.J., Russell P.S. Primarily vascularized allografts of hearts in mice the role of H-2D, H-2K and non H-2 antigens in rejection . Transplantation. 16:1973;343-350.
25. Niimi M, Hara M, Bushell A, Madsen JC, Morris PJ, Wood KJ. Results of heart transplantation in mice. In: W Timmermann, HJ Gassel, K Ulrichs, R Zhong, A Thiede, eds. Organ transplantation in rats and mice. Berlin: Springer, 1998:637-47.
26. Superina R.A., Peugh W.N., Wood K.J., Morris P.J. Assessment of primarily vascularized cardiac allografts in mice. Transplantation. 42:1986;226-227.
27. Odorico J.S., Barker C.F., Markmann J.F., Posselt A.M., Naji A. Prolonged survival of rat cardiac allografts after intrathymic inoculation of donor thymocytes. Transplant Proc. 25:1993;295-296.
28. Odorico J.S., O'Connor T., Campos L., Barker C.F., Posselt A.M., Naji A. Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow. Ann Surg. 218:1993;525-531.
29. Niimi M. An investigation to determine the ability of allogeneic resting B cells to induce specific unresponsiveness in vivo (PhD thesis). Oxford University, 1998.
30. Fuchs E.J., Matzinger P. B cells turn off virgin but not memory T cells. Science. 258:1992;1156-1159.
31. Modigliani Y., Coutinho A., Pereira P., et al. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur J Immunol. 26:1996;1807-1815.
32. Tomita Y., Khan A., Sykes M. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen. J Immunol. 153:1994;1087-1098.