Differential effect of cytokine treatment on Fcα receptor I- and Fcγ receptor I-mediated tumor cytotoxicity by monocyte-derived macrophages

Journal of Immunology

Volumn 164, Issue 11, 2000, Pages 5746-5752

  Keler, Tibor ^a   Wallace, Paul K ^b   Vitale, Laura A ^a   Russoniello, Christina ^a   Sundarapandiyan, Karuna ^a   Graziano, Robert F ^a   Deo, Yashwant M ^a  

^a MEDAREX INC   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; RECEPTOR SUBTYPE;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; MACROPHAGE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

EID: 0034081438     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.11.5746     Document Type: Article

References (34)

1. Herlyn, D., and H. Koprowski. 1982. IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells. Proc. Natl. Acad. Sci. USA 79:4761.
2. Dyall, R., L. V. Vasovic, R. A. Clynes, and J. Nikolic-Zugic. 1999. Cellular requirements for the monoclonal antibody-mediated eradication of an established solid tumor. Eur. J. Immunol. 29:30.
3. Van de Winkel, J. G. J., and C. L. Anderson. 1991. Biology of human immunoglobulin G Fc receptors. J. Leukocyte Biol. 49:511.
4. Van de Winkel, J. G. J., and P. J. A. Capel. 1993. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today 14: 215.
5. Shen, L. 1992. Receptors for IgA on phagocytic cells. Immunol. Res. 11:273.
6. Valerius, T., B. Stockmeyer, A. B. van Spriel, R. F. Graziano, I. E. van den Herik-Oudijk, R. Repp, Y. M. Deo, J. Lund, J. R. Kalden, M. Gramatzki, et al. 1997. FcαRI (CD89) as a novel trigger molecule for bispecific antibody therapy. Blood 90:4485.
7. Deo, Y. M., K. Sundarapandiyan, T. Keler, P. K. Wallace, and R. F. Graziano. 1998. Bispecific molecules directed to the Fc receptor for IgA (FcαRI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood. J. Immunol. 160:167.
8. Perussia, B., E. T. Dayton, R. Lazarus, V. Fanning, and G. Trichieri. 1983. Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. J. Exp. Med. 158:1092.
9. Guyre, P. M., P. M. Morganelli, and R. Miller. 1983. Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes, J. Clin. Invest. 72: 393.
10. Kerst, J. M., J. G. J. van de Winkel, A. H. Evans, M. de Haas, I. C. M. Slaper-Cortenbach, T. P. M. de Wit, A. E. G. K. von de Borne, C. E. van der Schoot, and R. H. J. van Oers. 1993. Granulocyte colony-stimulating factor induces hFcgRI (CD64 antigen)-positive neutrophils via an effect on myeloid precursor cells. Blood 81:1457.
11. Monteiro, R. C., M. D. Cooper, and H. Kubagawa. 1992. Molecular heterogenicity of Fcα receptor detected by receptor-specific monoclonal antibodies. J. Immunol. 148:1764.
12. Anderson, C. L., P. M. Guyre, J. C. Whitin, D. H. Ryan, R. J. Looney, and M. W. Fanger. 1986. Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes: antibody characterization and induction of superoxide production in a monocyte cell line. J. Biol. Chem. 261:12856.
13. Graziano, R. F., P. R. Tempest, P. White, T. Keler, Y. M. Deo, H. Ghebremariam, K. Coleman, L. C. Pfefferkorn, M. W. Fanger, and P. M. Guyre. 1995. Construction and characterization of a humanized anti-γ-Ig receptor type I (FcγRI) monoclonal antibody. J. Immunol. 155: 4996.
14. Stockmeyer, B., T. Valerius, R. Repp, I. A. F. M. Heijnen, H.-J. Buhring, Y. M. Deo, J. R. Kalden, M. Gramatzki, and J. G. J. van de Winkel. 1997. Preclinical studies with FcγR BsAb and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER2/neu overexpressing breast cancer. Cancer Res. 57:696.
15. Keler, T., R. F. Graziano, A. Mandal, P. K. Wallace, J. Fisher, P. M. Guyre, M. W. Fanger, and Y. M. Deo. 1997. Bispecific antibody-dependent cellular cytotoxicity of HER2/neu-overexpressing tumor cells by Fcγ receptor type I-expressing effector cells. Cancer Res. 57:4008.
16. Heijnen, I. A. F. M., L. J. M. Rijks, A. Schiel, B. Stockmeyer, H. H. van Ojik, R. Repp, T. Valerius, T. Keler, E. A. van Royen, P. J. A. Capel, et al. 1997. Generation of HER-2/neu-specific cylotoxic neutrophils in vivo: efficient arming of PMN by combined administration of G-CSF and FcγRI bispecific antibodies. J. Immunol. 159:5629.
17. Ravetch, J. V., and J. P. Kinet. 1991, Fc receptors. Annu. Rev. Immunol. 9:457.
18. Morton, H. C., I. E. van den Herik-Oudijk, P. Vossebeld, A. Snijders, A. J. Verhoeven, P. J. A. Capel, and J. G. J. van de Winkel. 1995. Functional association between the human myeloid IgA Fc receptor (CD89) and the FcR y chain: molecular basis for CD89/FcR γ chain association. J. Biol. Chem. 270: 29781.
19. Gessl, A., M. Willheim, A. Spittler, H. Agis, W. Krugluger, and Boltz-Nitulescu. 1994. Influence of tumor necrosis factor-α on the expression of FcIgG and IgA receptors, and other markers by cultured human blood monocytes and U937 cells. Scand. J. Immunol. 39:151.
20. Shen, L., J. E. Collins, M. H. Schoenborn, and C. R. Maliszewski. 1994. Lipopolysaccharide and cytokine augmentation of human monocyte IgA receptor expression and function, J. Immunol. 152:4080.
21. Reterink, T. J. F., E. W. N. Levarht, N. Klarmohamod, L. A. VanEs, and M. R. Daha. 1996. Transforming growth factor-β1 (TGF-β1) down regulates IgA Fc-receptor (CD89) expression on human monocytes. Clin. Exp. Immunol. 103: 161.
22. Van Schie, R. C. A. A., R. G. G. Verstraten, J. G. J. van de Winkel, W. J. M. Tax, and P. H. M. de Mulder. 1992. Effect of recombinant IFN-γ (rIFN-γ) on the mechanism of human macrophage IgG FcRI-mediated cytotoxicity. J. Immunol. 148:169.
23. Te Velde, A. A., R. de Waal Malefijt, R. J. F. Huijibens, J. E. de Vries, and C. G. Figdor. 1992. IL-10 Stimulates monocytes FcγR surface expression and cytotoxic activity. J. Immunol. 149:4048.
24. Munn, D. H., and E. Armstrong. 1993. Cytokine regulation of human monocyte differentiation in vitro: the tumor-cytotoxic phenotype induced by macrophage colony-stimulating facior is developmentally regulated by γ-interferon. Cancer Res. 53:2603.
25. Backman, K. A., and P. M. Guyre. 1994. γ-Interferon inhibits Fc receptor II-mediated phagocytosis of tumor cells by human macrophages. Cancer Res. 54: 2456.
26. Ely, P., P. K. Wallace, A. L. Givan, R. F. Graziano, P. M. Guyre, and M. W. Fanger. 1996. Bispecific-armed, interferon γ-primed macrophage-mediated phagocytosis of malignant non-Hodgkin's lymphoma. Blood 87:3813.
27. Munn, D. H., and N.-K. V. Cheung. 1990. Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulated factor. J. Exp. Med. 172:231.
28. Watanabe, M., P. K. Wallace, T. Keler, Y. M. Deo, and D. F. Hayes. 1999. Antibody dependent cellular phagocytosis (ADCP) and antibody dependent cellular cytotoxicity (ADCC) of breast cancer cells mediated by bispecific antibody. MDX-210. Breast Cancer Res. Treat. 53:199.
29. Leiveld, J. L., K. E. Frediani, J. M. Winslow, R. E. Duerst, and C. N. Abboud. 1991. Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage-mediated antibody dependent cellular cytotoxicity. J. Cell. Biochem. 45:381.
30. Erbe, D. V., J. E. Collins, L. Shen, R. F. Graziano, and M. W. Fanger. 1990. The effect of cytokines on the expression and function of Fc receptors for IgG on human myeloid cells. Mol. Immunol. 27:57.
31. Valone, F. H., P. A., Kaufman, P. M. Guyre, L. D. Lewis, V. Memoli, Y. M. Deo, R. F. Graziano, J. L. Fisher, L. Meyer, M. Mrozek-Orlowski, et al. 1995. Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpress the proto-oncogene HER2/neu. J. Clin. Oncol. 13: 2281.
32. Curnow, R. T. 1997. Clinical experience with CD64-directed immunotherapy: an overview. Cancer Immunol. Immunother. 45:210.
33. Launay, P., C. Patry, A. Leheun, B. Pasquier, U. Blank, and R. C. Monteiro. 1999. Alternative endocytic pathway for immunoglobulin A Fc receptors (CD89) depends on the lack of FcRγ association and protects against degradation of bound ligand. J. Biol. Chem. 274:7216.
34. Tripathi A. K., M. Taplitis, J. Puri, and T. Hoffman. 1991. Down-regulation of surface FcRI and decrease in antibody-dependent cellular cytotoxicity of cultured monocytes. J. Immunol. 146:1309.