Human red blood cell hemolysate is a potent mitogen for renal tubular epithelial cells

Renal Failure

Volumn 22, Issue 3, 2000, Pages 267-281

  Anderson, Robert J ^a,b   Ray, Carla J ^a   Burke, Thomas J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Blood hemolysate; Cell proliferation; Kidney cells

Indexed keywords

METHEMOGLOBIN; MITOGENIC AGENT; PROTEIN TYROSINE KINASE;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ERYTHROCYTE; HEMOLYSATE; HUMAN; HUMAN CELL; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE EPITHELIUM; MITOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; CELL DIVISION; CELLS, CULTURED; EPITHELIAL CELLS; ERYTHROCYTES; FEMALE; HEMOLYSIS; HUMANS; KIDNEY TUBULES; LLC-PK1 CELLS; MALE; MYOGLOBIN; PROBABILITY; SWINE; THYMIDINE; WOUND HEALING;

EID: 0034081184     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.1081/JDI-100100871     Document Type: Article

References (22)

1. th ed. Little, Brown and Co., Boston, pp1273-1299, 1997.
2. Paller MS: Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity. Am J Physiol 255:F539-F544, 1988.
3. Savitsky JP, Doczi J, Black J, Arnold JD: A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol 23:73-80, 1978.
4. Shah SV, Walker PD: Evidence suggesting a hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol 255:F438-F443, 1988.
5. Baker SL, Dodds EC: Obstruction of the renal tubule during the excretion of hemoglobin. Br J Exp Pathol 6:247-260, 1925.
6. Degowin EL, Osterhagen HF: Renal insufficiency from blood transfusion. I. Relation to urinary acidity. Arch Intern Med 59:432-434, 1937.
7. Jaenike JR: The renal lesion associated with hemoglobinemia: a study of the pathogenesis of the excretory defect in the rat. J Clin Invest 46:378-387, 1967.
8. Burke TJ, Falk S, Conger JD, Voelkel NF: Hemolysate - mediated renal vasoconstriction and hypersensitization. Renal Failure 21:23-33, 1999.
9. Somers MA, Piqueras I, Strange K, Zeidel M, Pfaller W, Gawryl M, Harris HW: Interactions of ultrapure bovine hemoglobin with renal epithelial cells in vivo and in vitro. Am J Physiol 273:F38-52, 1997.
10. Voelkel NF, Lobel K, Westcott JY, Burke TJ: Nitric oxide-related vasoconstriction in lungs perfused with red cell lysate. FASEB J 9:379-386, 1995.
11. Sponsel HT, Breckon R, Hammond W, Anderson RJ: Mechanisms of recovery from mechanical injury of renal tubular epithelial cells. Am J Physiol 267:F257-264, 1994.
12. Anderson RJ, Ray CJ: Potential autocrine and paracrine mechanisms of recovery from mechanical injury of renal tubular epithelial cells. Am J Physiol 274:F463-472, 1998.
13. 2 and terminal mitochondrial electron transport. Kidney Int 51:728-738, 1997.
14. Zager RA, Foerder CA: Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotocity. J Clin Invest 89:989-995, 1992.
15. Sponsel HT, Alfrey AC, Hammond W, Duer J, Ray C, Anderson RJ: Effect of iron on renal tubular epithelial cells. Kidney Int 50:436-444, 1996.
16. Zager RA, Schimpf BA, Bredl CR, Gmur DJ: Inorganic iron effects on in vitro hypoxic proximal renal tubular injury. J Clin Invest 91:702-708, 1993.
17. Moddaigh CR, Mach H, Burke DB, Valkin R, Dabara JM, Tsai PK, Bruner MW, Ryan JP, Marfia KE: Nature of the interaction of growth factors with suramin. Biochemistry 31:70016-70024, 1992.
18. Pimstone NR: Renal degradation of hemoglobin. Sem Hematol 9:31-42, 1972.
19. Karelin AA, Philippova MM, Ivanov VT: Proteolytic degradation of hemoglobin in erythocytes leads to biologically active peptides. Peptides 16:693-697, 1995.
20. Blishchenko EY, Mernenko OA, Yatskin ON, Ziganshin RH, Philippova MM, Karelin AA. Ivanov VT: Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth. FEBS Letters 414:125-128, 1997.
21. Bronnikov G, Dalgaecheva L, Zhang SJ, Galetovskaga E, Kramarova L, Zinehenko V: The effect of neuropeptides kyotorphin and neokyotorphin on proliferation of cultured brown adipocytes. FEBS Letters 407:73-77, 1997.
22. Balagopalaksrishna C, Bhrinia AK, Rifkinel JM, Chatteyee S: Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated kinase. Mol Cell Biochem 170:85-89, 1997.