Thrombopoietin activates the growth of megakaryoblasts in patients with chronic myeloproliferative disorders and myelodysplastic syndrome

European Journal of Haematology

Volumn 64, Issue 4, 2000, Pages 225-230

  Hashimoto, Shigeo ^a   Toba, Ken ^a   Fuse, Ichiro ^a   Watanabe, Kenichi ^a   Takahashi, Hidenobu ^a   Abe, Takashi ^a   Yano, Toshio ^a   Koike, Tadashi ^a   Takahashi, Masuhiro ^a   Aizawa, Yosifusa ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

C mpl; Chronic myeloproliferative disorders; Flow cytofluorometry; Myelodysplastic syndrome; Thrombopoietin

Indexed keywords

FIBRINOGEN RECEPTOR; THROMBOPOIETIN;

ARTICLE; BLAST CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEGAKARYOBLAST; MEGAKARYOCYTE; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL;

CELL DIFFERENTIATION; CELL DIVISION; CHRONIC DISEASE; HUMANS; MEGAKARYOCYTES; MYELODYSPLASTIC SYNDROMES; MYELOPROLIFERATIVE DISORDERS; THROMBOPOIETIN; TUMOR CELLS, CULTURED;

EID: 0034080821     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2000.90001.x     Document Type: Article

References (31)

1. 1. Bartley TD, Bogenberger J, Hunt P, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl. Cell 1994;77:1117-1124.
2. 2. De Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994;369:533-588.
3. 3. Lok S, Foster DC. The structure, biology and potential therapeutic applications of recombinant thrombopoietin. Stem Cells 1994;12:586-598.
4. 4. Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 1994;91:11104-11108.
5. 5. Wendling F, Markovsky E, Debili N, et al. C-mpl is a humoral regulator of megakaryopoiesis. Nature 1994;369: 571-574.
6. 6. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995;86:419-431.
7. 7. Banu N, Wang JF, Deng B, et al. Modulation of megakaryocytopoiesis by thrombopoietin: the c-mpl ligand. Blood 1995;86:1331-1338.
8. 8. Debili N, Wendling F, Katz A, et al. The mpl-ligand or thrombopoietin or megakaryocyte growth and development factor has both direct proliferative and differentiative activities on human magakaryocyte progenitors. Blood 1994;86: 2516-2525.
9. 9. Kaushansky K, Lok S, Holly RD, et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature 1994;369:568-571.
10. 10. Quentmeier H, Zaborski M, Graf G, et al. Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Leukemia 1996; 10:297-310.
11. 11. Hirai H, Shimazaki C, Yamagata N, et al. Effects of thrombopoietin (c-mpl ligand) on growth of blast cells from patients with transient abnormal myelopoiesis and acute myeloblastic leukemia. Eur J Haematol 1997;59:38-46.
12. 12. Matsumura I, Kanakura Y, Kato T, et al. Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood 1995;86:703-709.
13. 13. Motoji T, Takanashi M, Motomura S, et al. Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukaemia. Br J Haematol 1996; 94:513-516.
14. 14. Quentmeier H, Zaborski M, Graf G, et al. Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Leukemia 1996; 10:297-310.
15. 15. Piacibello W, Sanavio F, Brizzi MF, et al. Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl. Leukemia 1997;11:531-540.
16. 16. Toba K, Winton EF, Koike T, et al. Simultaneous three-color analysis of the surface phenotype and DNA-RNA quantitation using 7 aminoactinomycin D and pyronin Y. J Immunol Meth 1995;182:193-207.
17. 17. Toba K, Kishi K, Koike T, et al. Profile of cell cycle in hematopoietic malignancy by DNA/RNA quantitation using 7AAD/PY. Experimental Hematology 1996;24:894-901.
18. 18. Toba K, Koike T, Wang Y, et al. Prediction of growth sensitivity of acute promyelocytic leukemia cells to granulocyte colony-stimulating factor using 7AAD/PY during administration of all-trans retinoic acid. Int J Hematol 1997;66:203-212.
19. 19. Toba K, Koike T, Takahashi M, et al. Characterization and sensitivity to Interleukin 2 and Interferon α of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein Barr virus infection. Leukemia Res 1997;21:941-950.
20. 20. Koeffler HP, Golde DW. Acute myelogenous leukemia: A human cell line responsive colony stimulating activity. Science 1978;200:1153-1154.
21. 21. Ylanne J, Hormia M, Jbvinen M, Vartio T, Virtanen I. Platelet glycoprotein IIb/IIIa complex in cultured cells. Localization in focal adhesion sites in spreading HEL cells. Blood 1988;72:1478-1486.
22. 22. Sato T, Ota S, Kakuda H, et al. Expression of multidrug resistant gene (mdr-1/P-glycoprotein) in a megakaryoblastic cell line, CMK, and its enhancement during megakaryocytic differentiation. Leukemia and Lymphoma 1995;18:515-520.
23. 23. Imamura N, Inada T, Mtasiwa DM, Kuramoto A, Ogura M, Saito H. Demonstration of TSP receptor both on the cell surface and in the cytoplasm of the megakaryoblastic leukemia cell line (Meg-01). Am J Hematol 1989;32:78-79.
24. 24. Kishi K, Toba K, Azegami T, et al. Hematopoietic cytokine-dependent differentiation to eosinophils and neutrophils in a newly established acute promyelocytic leukemia cell line with t(15;17). Exp Hematol 1998;26:135-142.
25. 25. Kishi K. A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors. Leukemia Res 1985;9:381-390.
26. 26. Furukawa T, Koike T, Wang Ying, et al. Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis. Leukemia 1994; 8:171-180.
27. 27. Koike T. Megakaryoblastic leukemia: The characterization and identification of megakaryoblasts. Blood 1984;64:683-692.
28. 28. Bouscary D, Preudhomme C, Ribrag V, et al. C-mpl expression in hematologic disorders. Leukemia and Lymphoma 1995;17:19-26.
29. 29. Matsumura I, Kanakura Y, Ikeda H, et al. The effects of thrombopoietin on the growth of acute myeloblastic leukemia cells. Leukemia 1996;23:533-538.
30. 30. Matsumura I, Kanakura Y, Ikeda H, et al. Coexpression of thrombopoietin and c-mpl genes in human acute myeloblastic leukemia cells. Leukemia 1996;10:91-94.
31. 31. Graf G, Dehmel U, Drexler HG. Expression of thrombopoietin and thrombopoietin receptor mpl in human leukemia-lymphoma and solid tumor cell lines. Leukemia Res 1996;20:831-838.