Conceptualisation of diagnostic agents: From empirical in vivo screening to rational in vitro predictive parameters

Alternatives to Laboratory Animals

Volumn 28, Issue 2, 2000, Pages 303-314

  Belhadj Tahar, Hafid ^a,b   Boumahdi, Rachid ^b,c   Darbieu, Marie Hélène ^a,b  

^a LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^b CHU PURPAN   (France)

^c CNRS   (France)

Author keywords

Adsorption fraction; Imaging agent; Multiple regression analysis; Pharmacokinetic model; Scintigraphy; Technetium

Indexed keywords

METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; THALLIUM 201;

CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG ADSORPTION; DRUG SCREENING; HEART MUSCLE; HUMAN; HUMAN CELL; ISOTOPE LABELING; KIDNEY; LIPID SOLUBILITY; LIVER; LUNG; MEMBRANE MODEL; PRIORITY JOURNAL; SCINTISCANNING; SPLEEN; TISSUE DISTRIBUTION;

EID: 0034079760     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290002800201     Document Type: Conference Paper

References (34)

1. Comet, M. & Vidai, M. (1998). Radiopharmaceutiques, Chimie des Radiotraceurs et Applications Biologiques, pp. 151-669. Grenoble, France: Presse Universitaire.
2. 99mTc-labelled radiopharmaceuticals. Seminars in Nuclear Medicine XX, 5-27.
3. Srivastava, S.C. & Mease, R.C. (1991). Progress in research on ligands, nuclides and techniques for labelling monoclonal antibodies. Nuclear Medicine and Biology 18, 589-603.
4. Wiper, D.J. (1993). Functional neuroimagmg with single photon emission computed tomography (SPECT). Cerebrovascular and Brain Metabolism Reviews 5, 199-217.
5. Schelbert, H.R. (1987). Current status and prospects of new radionuclides and radiopharmaceuticals for cardiovascular nuclear medicine. Seminars in Nuclear Medicine XVII, 145-181.
6. Stöcklin, G., Qaim, S.M. & Rösch, F. (1995). The impact of radioactivity on medicine. Radiochimica Acta 70, 249-272.
7. Coleman, R.E. (1991). Single photon emission computed tomography and positron emission tomography in cancer imaging. Cancer 67, 1261-1270.
8. Guy, C.N. (1986). The second revolution in medical imaging. Contemporary Physics 37, 15-45.
9. Lauffer, R.B. (1987). Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design. Chimica Reviews 87, 901-927.
10. 99mTc-MIBI perfusion abnormality on single photon emission tomography: a quantitative validation with labelled water and positron emission tomography. European Journal of Nuclear Medicine 19, 1044-1049.
11. AHA/ACC (1995). AHA/ACC Task Force Report on guidelines for clinical use of cardiac radionuclide imaging. Circulation 91, 1278-1303.
12. 99mTc radiopharmaceuticals. In Technetium in Chemistry and Nuclear Medicine (ed. M. Nicolini, G. Bandoli & U. Mazzi), pp. 147-154. New York, USA: Raven Press.
13. Britton, K.E. (1990). Development of new radiopharmaceuticals. European Journal of Nuclear Medicine 16, 373-385.
14. Deutsch, E., Bushong, W., Glavan, K.A., Elder, R.C., Sodd, V.J., Scholz, L., Fortman, D.L. & Lukes, S.J. (1981). Heart imaging with cationic complexes of technetium. Science 214, 85-86.
15. Kronauge, J.F., Chiu, M.L., Cone, J.S., Davison, A., Holman, B.L., Jones, A.G. & Piwnica-Worms, D. (1992). Comparison of neutral and cationic myocardial perfusion agents: characteristics of accumulation in cultured cells. Nuclear Medicine and Biology 19, 141-148.
16. Belhadj-Tahar, H., Cros, G., Darbieu, M.H., Tafani, J.M., Coulais, Y. & Guiraud, R. (1994). Etude des potentialités de complexation de nouvelles bases de Schiff non-symetriques derivées de l'acide dithiocarboxylique avec le technétium. Medecine Nucléaire, Imagerie Fonctionnelle et Métabolique 18, 43.
17. 2 Schiff bases derived from 2-aminocyclopentene-1-dithiocarboxylic acid as potential heart imaging agents. Nuclear Medicine and Biology 21, 263-268.
18. 99m-technetium complexes. Nuclear Medicine and Biology 23, 353-357.
19. 2 unsaturated ligand derived from dithiocarboxylic acid. Inorganica Chimica Act 227, 25-31.
20. Belhadj-Tahar, H. (1996). Distribution Tissulaire des Complexes du Technetium-99m. PhD Thesis, University of Grenoble. 125pp. Grenoble, France.
21. 99m-N-NOEt in rat myocardium. Journal of Nuclear Medicine 36, 2075-2079.
22. 99m complexes with aminothiol ligands derived from aminocyclopentenedithiocarboxylic acid: physicochemical predictive parameters. In Fifth International Symposium on Applied Bioinorganic Chemistry, Book of Abstracts, 160pp. Ionnina, Greece: Printing Centre Ioannina University.
23. 99mTc complexes with assymetrical potentially dianionic or trianionic tetradentate SNNO ligands derived from methyl-2-aminocyclopentene-1-dithiocarboxylic acid. Nuclear Medicine and Biology 25, 65-70.
24. 99mTc oxo and nitrido complexes of unsaturated tetradentate (N2S2) ligands. Nuclear Medicine and Biology 20, 263-268.
25. Gandelman, V.S., Baldwin, R., Zoghbi, S., Zea-Ponce, Y. & Innis, R.B. (1994). Evaluation of ultrafiltration for the free-fraction determination of single photon emission computed tomography (SPECT) radiotracers. Journal of Pharmaceutical Sciences 23, 1014-1019.
26. Rigopulos, P. (1968). French Patent 1 521 021.
27. Rigopulos, P. (1970). US Patent 3 488 768.
28. Barre, J. & Houin, G. (1990). Pharmacocinétique, pp. 20-30. Paris, France: Ellipse.
29. Leo, A., Hansch, C. & Elkins, D. (1971). Partition coefficients and their uses. Chemical Reviews 71, 525-616.
30. Gremy, F. & Leterrier, F. (1981). Eléments de Biophysique, 2nd edn, pp. 587-595. Paris, France: Flammarion.
31. Münze, R., Kretzschmar, M., Syhre, R., Kampf, G., Klotzer, D., Guthert, I. & Bergmann, R. (1986). Biokinetic data of various radioactive cationic molecules: an attempt at evalution of significant chemical properties of myotropic agents. Technetium in Chemistry and Nuclear Medicine (ed. M. Nicolini, G., Bandoli & U. Mazzi), pp. 197-207. New York, USA: Raven Press.
32. 99mTc-MIBI. Nuclear Medicine and Biology 22, 585-588.
33. 99m-L,L-ECD for brain perfusion imaging. Journal of Nuclear Medicine 30, 1892-1901.
34. 99m chelator in nuclear medicine. Analyst 120, 863-866.