Antisense oligodeoxynucleotide inhibition of vascular angiotensin- converting enzyme expression attenuates neointimal formation: Evidence for tissue angiotensin-converting enzyme function

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 4, 2000, Pages 915-922

  Morishita, Ryuichi ^a   Gibbons, Gary H ^b   Tomita, Naruya ^a   Zhang, Lunan ^b   Kaneda, Yasufumi ^a   Ogihara, Toshio ^a   Dzau, Victor J ^b  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Antisense oligonucleotides; Gene therapy; Hemagglutinating virus of Japan; Renin angiotensin system; Restenosis

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; DIPEPTIDYL CARBOXYPEPTIDASE;

ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; GENE THERAPY; GENETIC TRANSFECTION; HEMODYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RESTENOSIS;

EID: 0034078429     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.4.915     Document Type: Article

References (45)

1. Dzau VJ, Brody T, Ellison KE, Pratt RE, Ingelfinger JR. Tissue specific regulation of renin expression in the mouse. Hypertension. 1987; 9(suppl III):III-36-III-41.
2. Dzau VJ, Burt DW, Pratt RE. Molecular biology of the renin angiotensin system. Am J Physiol. 1988;255:F563-F573.
3. Campbell DJ, Habener JF. Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest. 1986;78: 31-39.
4. Krieger JE, Dzau VJ. Molecular biology of hypertension. Hypertension. 1991;18(suppl I):I-3-I-17.
5. Morishita R, Higaki J, Miyazaki M, Ogihara T. Possible role of the vascular renin angiotensin system in hypertension and vascular hypertrophy. Hypertension. 1992;19(suppl II):II-62-II-67.
6. Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension. 1991; 18(suppl II):II-100-II-105.
7. Morishita R, Higaki J, Okunishi H, Tanaka T, Ishii K, Nagano M, Mikami H, Ogihara T, Murakami K, Miyazaki M. Changes in gene expression of the renin-angiotensin system in two-kidney, one clip hypertensive rats. J Hypertens. 1991;9:187-192.
8. Rakugi H, Jacob HJ, Krieger JE, Ingelfinger JR, Pratt RE. Vascular injury induces angiotensinogen gene expression in the media and neointima. Circulation. 1993;87:283-290.
9. Rakugi H, Kim DK, Krieger JE, Wang DS, Dzau VJ, Pratt RE. Induction of angiotensin converting enzyme in the neointima after vascular injury: possible role in restenosis. J Clin Invest. 1994;93:339-346.
10. Rakugi H, Wang DS, Dzau VJ, Pratt RE. Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation. Circulation. 1994;90:449-455.
11. Morishita R, Gibbons GH, Ellison KE, Lee WS, Zhang L, Yu H, Kaneda Y, Ogihara T, Dzau VJ. Evidence for direct local effect of angiotensin in vascular hypertrophy: in vivo gene transfer of angiotensin converting enzyme. J Clin Invest. 1994;94:978-984.
12. Kaneda Y, Uchida T, Makeda E, Nakanishi M, Okada Y. Entry of diphtheria toxin into cells: possible existence of cellular factor(s) for entry of diphtheria toxin into the cells was studied in somatic cell hybrids and hybrid toxins. J Cell Biol. 1984;98:466-472.
13. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Pharmacokinetics of antisense oligonucleotides (cyclin B1 and cdc 2 kinase) in the vessel wall: enhanced therapeutic utility for restenosis by HVJ-liposome method. Gene. 1994;149:13-19.
14. Okada Y. Factors in fusion of cells by HVJ. Curr Top Microbiol Immunol. 1969;48:102-128.
15. Homma M. Trypsin action on the growth of Sendai virus in tissue culture cells I: restoration of the infectivity for L cells by direct action of trypsin on L cell-borne Sendai virus. J Virol. 1971;8:619-629.
16. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Single intraluminal delivery of antisense cdc 2 kinase and PCNA oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci U S A. 1993;90:8474-8479.
17. Morishita R, Gibbons GH, Ellison KE, Nakajima N, von der Leyen H, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest. 1994;93:1458-1464.
18. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel and effective gene transfer technique for study of vascular renin angiotensin system. J Clin Invest. 1993;91:2580-2585.
19. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. Hypertension. 1993;21:894-899.
20. Kaneda Y, Iwai K, Uchida T. Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science. 1989;243:375-378.
21. Lilley DM. DNA-protein interactions. HMG has DNA wrapped up. Nature. 1992;357:282-283.
22. Walder RY, Walder JA. Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc Natl Acad Sci U S A. 1988;85: 5011-5015.
23. Busen W. Purification, subunit structure, and serological analysis of calf thymus ribonuclease H1. J Biol Chem. 1980;255:9434-9443.
24. Cushman DW, Cheung HS. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol. 1970;20:11637-11648.
25. Deleted in proof.
26. Rakugi H, Wang D, Giachelli C, Schwartz SM, Dzau VJ, Pratt RE. Developmentally regulated production of angiotensin converting enzyme in cultured rat vascular smooth muscle cells. J Hypertens. 1992;10:S127. Abstract.
27. Hughes EN, Engelsberg BN, Billings PC. Purification of nuclear proteins that bind to cisplatin-damaged DNA: identity with high mobility group proteins 1 and 2. J Biol Chem. 1992;267:13520-13527.
28. PM Pil, Lippard SJ. Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin. Science. 1992;256: 234-237.
29. Fisher RP, Lisowsky T, Parisi MA, Clayton DA. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem. 1992;267:3358-3367.
30. Marcus-Sekura CJ. Techniques for using antisense oligodeoxynucleotides to study gene expression. Anal Biochem. 1988;172:289-295.
31. Stein CA, Cohen JS. Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res. 1988;48:2659-2668.
32. Akhtar S, Juliano RL. Cellular uptake and intracellular fate of antisense oligonucleotides. Trends Cell Biol. 1992;2:139-144.
33. Agrawal S, Mayrand SH, Zamecnik PC, Pederson T. Site-specific excision from RNA by RNase H and mixed-phosphate-backbone oligodeoxynucleotides. Proc Natl Acad Sci U S A. 1990;87:1401-1405.
34. Simons M, Edelman ER, Dekeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 1992;359:67-70.
35. Kauffman RF, Bean JS, Zimmerman KM, Brown RF, Steinberg MI. Losartan, a nonpeptide angiotensin II (Ang II) receptor antagonist, inhibits neointima formation following balloon injury to rat carotid arteries. Life Sci. 1991;49:PL223-PL228.
36. Powell JS, Clozel JP, Muller RKM, Kuhn H, Hefti F, Hosang M, Baumgartner HR. Inhibitors of angiotensin converting enzyme prevent myointimal proliferation after vascular injury. Science. 1989;245:186-188.
37. Dzau VJ, Mann MJ, Morishita R, Kaneda Y. Fusigenic viral liposome for gene therapy in cardiovascular diseases. Proc Natl Acad Sci U S A. 1996;93:11421-11425.
38. Kaneda Y, Uchida T, Kim J, Ishiura M, Okada Y. The improved efficient method for introducing macromolecules into cells using HVJ (Sendai virus) liposome with gangliosides. Exp Cell Res. 1987;173:56-69.
39. Nakanishi M, Uchida T, Sugawa H, Ishiura M, Okada Y. Efficient introduction of contents of liposome into cells using HVJ (Sendai virus). Exp Cell Res. 1985;159:399-409.
40. Leonetti JP, Mechti N, Degols G, Gagnor C, Lebleu B. Intracellular distribution of microinjected antisense oligonucleotides. Proc Natl Acad Sci U S A. 1991;88:2702-2706.
41. Chin DJ, Green GA, Zon G, Szoka FC, Straubinger RM. Rapid nuclear accumulation of injected oligodeoxynucleotides. New Biol. 1990;2: 1091-1100.
42. MERCATOR Study Group. Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Circulation. 1992;86:110-110.
43. MARCATOR Investigators. Angiotensin converting enzyme inhibition and restenosis: the final results of MARCATOR Trial. Circulation. 1992; 86(suppl I):I-53. Abstract.
44. Urata H, Kinoshita A, Perez DM, Misono KS, Bumpus FM, Graham RM, Husain A. Cloning of the gene and cDNA for human heart chymase. J Biol Chem. 1991;266:17173-17179.
45. Shiota N, Okunishi H, Fukamizu A, Sakonjo H, Kikumori M, Nishimura T, Nakagawa T, Murakami K, Miyazaki M. Activation of two angiotensin-generating systems in the balloon-injured artery. FEBS Lett. 1993; 323:239-242.