Progressive renal disease: Does the quality of the proteinuria matter or only the quantity?

Clinica Chimica Acta

Volumn 297, Issue 1-2, 2000, Pages 43-54

  Newman, D J ^a   Thakkar, H ^b   Gallagher, H ^a  

^a ST HELIER HOSPITAL   (United Kingdom)

^b Pathology Laboratory   (United Kingdom)

Author keywords

Interstitial fibrosis; Protein type; Proteinuria; Renal disease

Indexed keywords

RETINOL BINDING PROTEIN;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; EPITHELIUM CELL; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DISEASE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEINURIA; QUANTITATIVE ASSAY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

CELL LINE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-6; KIDNEY FAILURE; PROTEINURIA; RETINOL-BINDING PROTEINS; SERUM ALBUMIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034077859     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(00)00232-1     Document Type: Article

References (42)

1. Abbate M., Zoja C., Corna D., Capitanio M., Bertani T., Remuzzi G. In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. J Am Soc Nephrol. 9:1998;1213-1224.
2. Jackle I., Gunther W., von Gise H., Alt J.M., Bohle A., Stolte H. Kidney function and protein excretion in relation to pathomorphology of glomerular diseases. Contrib Nephrol. 68:1988;128-135.
3. D'Amico G. Clinical factors in progressive renal injury. Am J Kidney Dis. 17:1991;48-52.
4. Cameron J.S. Proteinuria and progression in human glomerular diseases. Am J Nephrol. 1:1990;81-87.
5. Breyer J.A., Bain R.P., Evans J.K., et al. Predictors of the progression of renal insufficiency in patients with insulin-dependent diabetes and overt diabetic nephropathy. Kidney Int. 50:1996;1651-1658.
6. Ruggenenti P., Perna A., Mosconi L., Pisoni R., Remuzzi G. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. Kidney Int. 53:1998;1209-1216.
7. Hostetter T.H., Olson J.L., Rennke H.G., Venkatachalam M.A., Brenner B.M. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol. 241:1981;F85-93.
8. Brenner B.M., Meyer T.W., Hostetter T.H. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 307:1982;652-659.
9. Williams J.D., Coles G.A. Proteinuria - a direct cause of renal morbidity? Kidney Int. 45:1994;443-450.
10. Wang Y., Chen J., Chen L., Tay Y.C., Rangan G.K., Harris D.C. Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein. J Am Soc Nephrol. 8:1997;1537-1545.
11. Zoja C., Donadelli R., Colleoni S., et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int. 53:1998;1608-1615.
12. Zoja C., Morigi M., Figliuzzi M., et al. Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins. Am J Kidney Dis. 26:1995;934-941.
13. Remuzzi G., Ruggenenti P., Benigni A. Understanding the nature of renal disease progression. Kidney Int. 51:1997;2-15.
14. Schwegler J.S., Heppelmann B., Mildenberger S., Silbernagl S. Receptor-mediated endocytosis of albumin in cultured opossum kidney cells: a model for proximal tubular protein reabsorption. Pfluger's Arch Eur J Physiol. 418:1991;383-392.
15. Brown D., Stow J.L. Protein trafficking and polarity in kidney epithelium: from cell biology to physiology. Physiol Rev. 76:1996;245-297.
16. Marshansky V., Bourgoin S., Londono I., Bendayan M., Maranda B., Vinay P. Receptor-mediated endocytosis in kidney proximal tubules: recent advances and hypothesis. Electrophoresis. 18:1997;2661-2676.
17. Brunskill N.J., Nahorski S., Walls J. Characteristics of albumin binding to opossum kidney cells and identification of potential receptors. Pfluger's Arch Eur J Physiol. 433:1997;497-504.
18. Cessac-Guillemet A.L., Mounier F., Borot C., et al. Characterization and distribution of albumin binding protein in normal rat kidney. Am J Physiol. 271:1996;F101-F107.
19. Kerjaschki D., Farquhar M.G. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA. 79:1982;5557-5581.
20. Cui S., Verroust P.J., Moestrup S.K., Christensen E.I. Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol. 271:1996;F900-F907.
21. Maack T., Park C.H., Camargo M.J.F. Renal filtration, transport, and metabolism of proteins. Seldin D.W., Giebisch G. The kidney: physiology and pathophysiology. 1985;1773-1803 Raven Press, New York.
22. Dixon R., Brunskill N.J. Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial cells: implications for the pathophysiology of proteinuric states. J Am Soc Nephrol. 10:1999;1487-1497.
23. Maack T., Johnson V., Kau S.T., Figueiredo J., Sigulem D. Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review. Kidney Int. 16:1979;251-270.
24. Bernard A., Viau C., Ouled A., Lauwerys R. Competition between low- and high-molecular-weight proteins for renal tubular uptake. Nephron. 45:1987;115-118.
25. Thielemans N., Lauwerys R., Bernard A. Competition between albumin and low-molecular-weight proteins for renal tubular uptake in experimental nephropathies. Nephron. 66:1994;453-458.
26. Simonnet H., Gauthier C., Vincent C., Revillard J.P. The binding of beta-2-microglobulin to renal brush-border membrane: affinity measurement, inhibition by serum albumin. Biochim Biophys Acta. 940:1988;247-254.
27. Simonnet-Nguyen H., Gauthier C., Vincent C., Revillard J.P. Renal brush border membrane binding of beta 2-microglobulin is rapid, saturable and inhibited by albumin. Contrib Nephrol. 68:1988;26-31.
28. Thakkar H., Lowe P.A., Price C.P., Newman D.J. Measurement of the kinetics of protein uptake by proximal tubular cells using an optical biosensor. Kidney Int. 54:1998;1197-1205.
29. Bazzi C., Petrini C., Rizza V., Arrigo G., Beltrame A., D'Amico G. Characterization of proteinuria in primary glomerulonephritides. Am J Kidney Dis. 29:1997;27-35.
30. Sanders P.W., Herrera G.A., Chen A., Booker B.B., Galla J.H. Differential nephrotoxicity of low molecular weight proteins including Bence Jones proteins in the perfused rat nephron in vivo. J Clin Invest. 82:1988;2086-2096.
31. Burton C.J., Combe C., Walls J., Harris K.P. Fibronectin production by human tubular cells: the effect of apical protein. Kidney Int. 50:1996;760-767.
32. Markovic-Lipkovski J., Muller C.A., Risler T., Bohle A., Muller G.A. Association of glomerular and interstitial mononuclear leukocytes with different forms of glomerulonephritis. Nephrol Dialysis Transplant. 5:1990;10-17.
33. Frank J., Engler-Blum G., Rodemann H.P., Muller G.A. Human renal tubular cells as a cytokine source: PDGF-B, GM-CSF and IL-6 mRNA expression in vitro. Exp Nephrol. 1:1993;26-35.
34. Tamaki K., Okuda S., Ando T., Iwamoto T., Nakayama M., Fujishima M. TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy. Kidney Int. 45:1994;525-536.
35. Eddy A.A. Molecular insights into renal interstitial fibrosis [editorial]. J Am Soc Nephrol. 7:1996;2495-2508.
36. Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A., Torok-Storb B. HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int. 45:1994;48-57.
37. Daniels B.S., Hauser E.B., Deen W.M., Hostetter T.H. Glomerular basement membrane: in vitro studies of water and protein permeability. Am J Physiol. 262:1992;F919-926.
38. Oken D.E., Flamenbaum W. Micropuncture studies of proximal tubule albumin concentrations in normal and nephrotic rats. J Clin Invest. 50:1971;1498-1505.
39. Van der Biest I., Nouwen E.J., Van Dromme S.A., De Broe M.E. Characterization of pure proximal and heterogeneous distal human tubular cells in culture. Kidney Int. 45:1994;85-94.
40. Nielsen R., Birn H., Moestrup S.K., Nielsen M., Verroust P., Christensen E.I. Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin. J Am Soc Nephrol. 9:1998;1767-1776.
41. Bayer E.A., Wilchek M. Protein biotinylation. Methods Enzymol. 184:1990;138-160.
42. Muller G.A., Markovic-Lipkovski J., Frank J., Rodemann H.P. The role of interstitial cells in the progression of renal diseases. J Am Soc Nephrol. 2:1992;S198-205.