Does the addition of pindolol accelerate the response to electroconvulsive therapy in patients with major depression? A double-blind, placebo-controlled pilot study

Journal of Clinical Psychopharmacology

Volumn 20, Issue 3, 2000, Pages 373-378

  Shiah, I Shin ^a,b   Yatham, Lakshmi N ^a   Srisurapanont, Manit ^a   Lam, Raymond W ^a   Tam, Edwin M ^a   Zis, Athanasios P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PINDOLOL; SEROTONIN 1A ANTAGONIST;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG POTENCY; ELECTROCONVULSIVE THERAPY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCORING SYSTEM; TREATMENT OUTCOME;

ADRENERGIC BETA-ANTAGONISTS; ADULT; COMBINED MODALITY THERAPY; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; ELECTROCONVULSIVE THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PINDOLOL; PSYCHIATRIC STATUS RATING SCALES; TIME FACTORS;

EID: 0034076298     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-200006000-00015     Document Type: Article

References (20)

1. Artigas F, Ferez V, Alvarez E. Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch Gen Psychiatry 1994;51:248-51.
2. Blier P, Bergeron R. Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. J Clin Psychopharmacol 1995;15:217-22.
3. Vinar O, Vinarova E, Horacek J. Pindolol accelerates the therapeutic action of selective serotonin reuptake inhibitors (SSRI) in depression. Homeostasis 1996;37:93-5.
4. Bakish D, Hooper CL, Thornton MD, Wiens A, Miller CA, Thibaudeau CA. Fast onset - an open study of the treatment of major depressive disorder with nefazodone and pindolol combination therapy. Int Clin Psychopharmacol 1997;12:91-7.
5. Blier P, Bergeron R, de Montigny C. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology 1997;16:333-8.
6. Berman RM, Darnell AM, Miller HL, Anand A, Charney DS. Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial. Am J Psychiatry 1997;154:37-43.
7. Perez V, Gilaberte I, Faries D, Alvarez E, Artigas F. Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet 1997;349: 1594-7.
8. Tome MB, Issac MT, Harte R, Holland C. Paroxetine and pindolol - a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency. Int Clin Psychopharmacol 1997;12:81-9.
9. Zanardi R, Artigas F, Franchini L, Sforzini L, Gasperini M, Smeraldi E, Perez J. How long should pindolol be associated with paroxetine to improve the antidepressant response? J Clin Psychopharmacol 1997;17:446-50.
10. Bordet R, Thomas P, Dupuis B. Effect of pindolol onset of action of paroxetine in the treatment of major depression: intermediate analysis of a double-blind, placebo-controlled trial. Reseau de Recherche et d'Experimentation Psychopharmacologique. Am J Psychiatry 1998;155:1346-51.
11. Moreno FA, Gelenberg AJ, Bachar K. Pindolol augmentation of treatment-resistant depressed patients. J Clin Psychiatry 1997;58: 437-9.
12. Abrams R. Memory and cognitive functioning after ECT. In: Abrams R, ed. Electroconvulsive therapy. 3rd ed. New York: Oxford University Press, 1997:212-50.
13. Michael E, Rush JA. Treatment-resistant depression. In: Bloom FE, Kupfer DJ, eds. Psychopharmacology: the fourth generation of progress. New York: Raven Press, 1995:1081-97.
14. Spitzer RL, Williams JBW, Gibbon M, First MB. Structured Clinical Interview for DSM-III-R, patient edition. Washington, DC: American Psychiatric Association, 1990.
15. Williams JBW, Link M, Rosenthal NE. Structured interview guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH-SAD). New York: New York Psychiatric Institute, 1991.
16. 1A antagonists. Trends Neurosci 1996;19:378-83.
17. Goodwin GM, DeSouza RJ, Green AR. Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock. Nature 1985;317:531-3.
18. Bill A, Knight M, Forster EA, Fletcher A. Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia. Br J Pharmacol 1991;103:1857-64.
19. Blier P, Bouchard C. Effect of repeated electroconvulsive shocks on serotonergic neurons. Eur J Pharmacol 1992;211:365-73.
20. Gur E, Lerer B, Newman ME. Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo micodialysis study. J Neural Transm 1997;104:795-804.