Design, synthesis, and pharmacological evaluation of soft glycopyrrolate and its analog

Pharmazie

Volumn 55, Issue 3, 2000, Pages 187-191

  Ji, F ^a   Huang, F ^a   Juhasz, A ^a   Wu, W ^a   Bodor, Nicholas ^a,b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; GLYCOPYRRONIUM BROMIDE; MUSCARINIC RECEPTOR; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICHOLINERGIC EFFECT; ARTICLE; CARBOXYLATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; MALE; NONHUMAN; RABBIT; RAT;

ADMINISTRATION, TOPICAL; ANIMALS; BRADYCARDIA; CARBACHOL; EYE; GLYCOPYRROLATE; GUINEA PIGS; ILEUM; INJECTIONS, INTRAVENOUS; MALE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MYDRIATICS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC;

EID: 0034075060     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Hamborg, P. B.; Neilsen, M. M; Thordal, C.: Acta Ophthalmol. Copenh. 62, 485 (1984)
2. Birkhimer, L. J.; Jacobson, P. A.; Olson, J.; Goyette, D. M.: J. Fam. Prac. 18, 464 (1984)
3. Bodor, N.; Woods, R.; Raper, C.; Kearney, P.; Kaminski, J.: J. Med. Chem. 23, 474 (1980)
4. Bodor, N.: The Soft Drug Approach. Chemtech. 14(1), 28 (1984)
5. Hammer, R. H.; Amin, K.; Gunes, E.; Brouilette, G.; Bodor, N.: Drug Design Discov., 2, 207 (1988)
6. Hammer, R. H.; Wu, W.; Sastry, J. S.; Bodor, N.: Curr. Eye Res. 10, 565 (1991)
7. Kumar, G. N.; Hammer, R. H.; Bodor, N.: Drug Design Discov. 10, 11 (1993)
8. Brouilette, G.; Kawamura, M.; Kumar, G. N.; Bodor, N.: J. Pharm. Sci. 85, 619 (1996)
9. Crowther, G. P.; Kaizer, E. M.; Woodruff, R. A.; Hauser, C. R.: Esterification of Hindered Alcohols: tert-Butyl p-Toluate. In: Noland, E. W. (ed.): Organic Syntheses v. 6, p. 259 John Wiley & Sons 1988
10. Reiffers, S.; Wynberg, H.; Strating, J.: Tetrahedron Lett. 3001 (1971)
11. Kumar, G. N.; Huang, M. J.; Hammer, R. H.; Bodor, N.: J. Pharm. Sci. 83, 117 (1994)
12. Cheng, Y. C.; Prusoff, W. H.: Biochem. Pharmacol. 22, 3099 (1973)
13. Van Rossum, J. M.; Hurkmans, J. H.; Wolters, C. J.: Arch. Int. Pharmacodyn. Therap. 143, 299 (1963)
14. Higgins, C. B.; Vatner, S. F.; Braunwald, E.: Pharmacol. Rev. 25, 119 (1973)