A Specific Thrombin Inhibitor (Argatroban) Ameliorated Cerebral Blood Flow in the Patients with Acute Cerebral Infarction

Keio Journal of Medicine

Volumn 49, Issue , 2000, Pages A138-A147

  Maruki, Yuichi ^a   Onoda, Atsuhiro ^a   Matsuzaki, Masaaki ^a   Narabayashi, Yousuke ^a   Sawada, Masahiko ^a   Shimazu, Kunio ^b  

^a Saitama Neuropsychiatric Institute   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Key word; microcirculation; penumbra; Xe CT

Indexed keywords

ARGATROBAN; XENON;

ADULT; AGED; BRAIN BLOOD FLOW; BRAIN INFARCTION; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; FEMALE; HUMAN; MALE;

AGED; AGED, 80 AND OVER; ANIMALS; ANTITHROMBINS; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PIPECOLIC ACIDS; TOMOGRAPHY, X-RAY COMPUTED; XENON;

EID: 0034074329     PISSN: 00229717     EISSN: 18801293     Source Type: Journal    
DOI: 10.2302/kjm.49.supplement1_A138     Document Type: Article

References (5)

1. Okamoto S, Hijikata A, Kikumoto R, Tonomura S, Hara H, Ninomiya K, Maruyama A, Sugano M, Tamao K: Potent inhibition of thrombin by the newly synthesized arginine derivative No 805. The importance of stereosturucture of its hydrophobic carboxamide portion. Biochem Biophys Res Commun 1981; 101: 440-446
2. Kobayashi S, Tazaki Y : Effect of thrombin inhibitor Argatroban in acute cerebral thrombosis. Seminars in thrombosis and hemostasis 1997; 23: 531-534
3. Kawai Y, Yuki S, Sugimpto J, Tmao Y: Effect of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Phamacol Exp Ther 1996; 278: 780-785
4. Heye N, Cervos-Navarro J: Microthromboemboli in acute infarcts, analysis of 40 autopsy cases. Stroke 1996; 27: 431-434
5. Sampaolo S.J., Cervos-Navarro J, Djouchadar D, Figols J: Clinical and experimental evidence of microthrombosis in cerebral ischemia. In: Hartmann A, Kuschinsky, eds, Cerebral ischemia and hemorheology, Berlin-Heidelberg, Springer, 1987; 386-393