Clinical and technical considerations for imaging colorectal cancers with technetium-99m-labeled antiCEA fab' fragment

Journal of Nuclear Medicine Technology

Volumn 28, Issue 1, 2000, Pages 12-18

  Erb, Deborah A ^a   Nabi, Hani A ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Colorectal cancer; Technetium 99m Arcitumomab; Technetium 99m labeled CEA Scan ; Tumor specific radiolabeled antibody imaging

Indexed keywords

ANTIBODY CONJUGATE; ARCITUMOMAB TC 99M; CARCINOEMBRYONIC ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; TECHNETIUM 99M;

ARTICLE; CANCER DIAGNOSIS; CLINICAL TRIAL; COLORECTAL CANCER; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; HUMAN; ISOTOPE LABELING; LIVER METASTASIS; MAJOR CLINICAL STUDY; PHASE 3 CLINICAL TRIAL; PREOPERATIVE EVALUATION; QUALITY CONTROL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANTIBODIES, MONOCLONAL; COLORECTAL NEOPLASMS; CONTRAST MEDIA; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIVER NEOPLASMS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0034073628     PISSN: 00914916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Cancer Facts and Figures. Atlanta, GA: American Cancer Society, Inc.; 1996:10-11.
2. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495-497.
3. Goldenberg DM, DeLand F, Kim E, et al. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med. 1978;298:1384-1386.
4. Nabi HA. Radiolabeled antibodies in clinical nuclear medicine: a technology coming of age. In: LM Freeman, ed. Nuclear Medicine Annual. New York, NY: Raven Press Ltd.; 1993:1-27.
5. CEA-Scan® package insert for preparing technetium-99m Arcitumomab. Morris Plains, NJ: Immunomedics, Inc.
6. Hughes K, Pinsky CM, Petrelli NJ, et al. Use of carcinoembryonic antigen radioimmunodetection and computed tomography for predicting the resectability of recurrent colorectal cancer. Ann Surg. 1997;226:621-631.
7. Galandiuk S, Wieand HS, Moertel CG, et al. Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surg Gynecol Obstet. 1992;174:27-32.
8. Benjamin IS, Blumgart LH. Hepatic resection for liver metastases. Dig Dis. 1988;6:40-51.
9. Hughes KS, Simon R, Songhorabodi S, et al. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection. Surg. 1988;103:278-288.
10. Steele G Jr, Bleday R, Mayer RJ, et al. A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver. Gastrointestinal Tumor Study Group Protocol 6584. J Clin Oncol. 1991;9:1105-1112.
11. Steele G Jr, Ravikumar TS. Resection of hepatic metastases from colorectal cancer. Biologic perspective. Ann Surg. 1989;21:127-138.
12. Freeny PC, Mark WM, Ryan JA, Bolen JW. Colorectal carcinoma evaluation with CT: preoperative staging and detection of postoperative recurrence. Radiology. 1986;158:347-353.
13. Thompson WM, Halvorsen RA Jr. Computed tomographic staging of gastrointestinal malignancies Part II. The small bowel, colon, and rectum. Invest Radiol. 1987;22:96-105
14. Doerr RJ, Abdel-Nabi H, Krag D, Mitchell E. Radiolabeled antibody imaging in the management of colorectal cancer. Results of a multicenter clinical study. Ann. Surg. 1991;214:118-124.
15. Haseman MK, Brown DW, Keeling CA, Reed NL. Radioimmunodetection of occult carcinoembryonic antigen-producing cancer. J Nuc Med. 1992;33: 1750-1756.
16. 111In-C1110 Int J Rad Appl Instrum [B]. 1991;18:705-710.
17. Abdel-Nabi H, Doerr RJ. Clinical applications of indium-111-labeled monoclonal antibody imaging in colorectal cancer patients. Semin Nuc Med. 1993;23:99-113.
18. Abdel-Nabi H, Doerr RJ. Detection of recurrent colorectal cancer: an algonthm for immunoscintigraphy. Appl Radiology. 1994;23:11-16.
19. Patt YZ, Podoloff DA, Curley S, et al Technetium-99m labeled IMMU-4, a monoclonal antibody against carcinoembryonic antigen, for imaging of occult recurrent colorectal cancer in patients with rising serum carcinoembryonic antigen levels. J Clin Oncol 1994;12:489-495.
20. Moffat FL Jr, Pinsky CM, Hammershaimb L, et al. Clinical utility of external immunoscintigraphy with IMMU-4 technetium-99m Fabá antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, Phase III trial. J Clin Oncol. 1996;14:2295-2305.