Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism

Anticancer Research

Volumn 20, Issue 1 A, 2000, Pages 225-228

  Hsieh, Tze Chen ^a   Wu, Joseph M ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Androgen receptor (AR); Prostate LNCaP cells; Prostate specific antigen (PSA); Resveratrol

Indexed keywords

ANDROGEN RECEPTOR; METRIBOLONE; POLYPHENOL; PROSTATE SPECIFIC ANTIGEN; RESVERATROL; TRITIUM;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; GRAPE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; WINE;

ADENOCARCINOMA; ANDROGENS; ANTIBODIES, MONOCLONAL; ANTICARCINOGENIC AGENTS; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; DEPRESSION, CHEMICAL; ENZYME INDUCTION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR FLUID; MALE; METRIBOLONE; NEOPLASMS, HORMONE-DEPENDENT; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RADIOLIGAND ASSAY; RECEPTORS, ANDROGEN; ROSALES; STILBENES; TUMOR CELLS, CULTURED;

EID: 0034073147     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Parker SL, Tong T, Bolden S and Wingo PA: Cancer statistics. CA Canc J Clin 47: 5-27, 1997.
2. Bosland MC: Hormonal factors in carcinogenesis of the prostate and testis in humans and in animal models. In: "Cellular and molecular mechanisms of hormonal carcinogenesis: Environmental influences" (Huff J, Boyd J and Barrett JC Eds.), Wiley-Liss, Inc., New York, 1996.
3. Isaacs JT: Prostatic cancer: an age-old problem. In: "The underlying molecular, cellular, and immunological factors in cancer and agingrdblquote (Yang SS, and Warner HR Eds), Plenum Press, New York, 1993.
4. Keetch DW, and Andriole GL: The use of tumor markers in prostate cancer. In: "Prostate cancer" (Dawson, NA and Vogelzang, NJ Eds.), Wiley-Liss, Inc. New York, 1994.
5. Whittemore AS, Lele C, Friedman GD, Stamey T, Vogelman JH and Orentreich N: Prostate-specific antigen as predictor of prostate cancer in black men and white men. J Natl Canc Inst 87: 354-360, 1995.
6. Herrada J, Dicringer P and Logothetis CJ: Characterization of patients with androgen-independent prostatic carcinoma whose serum prostate specific antigen decreased following flutamide withdrawal. J Urol 155: 620-623, 1996.
7. Riegman PH, Vlietstra RJ, van der Korput JA, Brinkmann AO and Trapman J: The promoter of the prostate specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 5: 1921-1930, 1991.
8. Montgomery BT, Young CY, Bilhartz DL, Andrews PE, Prescott JL, Thompson NF and Tindall DJ: Hormonal regulation of prostate-specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaP. The Prostate 21: 63-73, 1992.
9. Gau JT, Salter RD, Krill D, Grove ML and Becich MJ: The biosynthesis and secretion of prostate-specific antigen in LNCaP cells. Canc Res 57: 3830-3834, 1997.
10. Lindzey M, Kumar MV, Grossman M, Young C and Tindall DJ: Molecular mechanisms of androgen action. Vitamins and Hormones 49: 383-432, 1994.
11. Wang LG, Liu XM, Kreis W and Budman DR: Down-regulation of prostate-specific antigen expression by finasteride through inhibition of complex formation between androgen receptor and steroid receptor-binding consensus in the promoter of the PSA gene in LNCaP cells. Cancer Res 57: 714-719, 1997.
12. Lee C, Sutkowski DM, Sensibar JA, Zelner D, Kim I, Amsel I, Shaw N, Prins GS and Kozlowski JM: Regulation of proliferation and production of prostate-specific antigen in androgen-sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone. Endocrinology 136: 796-803, 1995.
13. 3 in the androgen-dependent LNCaP cells. Biochem Biophys Res Commun 223: 141-146, 1996.
14. Hsieh TC, Chen SS, Wang W and Wu JM: Regulation of androgen receptor (AR) and prostate specific antigen (PSA) expression in the androgen-responsive human prostate LNCaP cells by ethanolic extracts of the Chinese herbal preparation, PC-SPES. Biochem Mol Biol Int 42: 535-544, 1997.
15. 3 in androgen-dependent LNCaP cells. Biochem Biophys Res Commun 235: 539-544, 1997.
16. Konno S, Mordente JA, Chen Y, Wu JM, Tazaki H and Mallouh C: Effects of brefeldin A on androgen receptor-mediated cellular responses in human prostatic carcinoma LNCaP cells. Mol Urol 2: 7-11, 1998.
17. Miller AB: Diet and cancer: a review. Rev Oncol 3: 87-95, 1990.
18. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CWW, Fong HHS, Farnsworth NR, Kinghorn D, Mehta RG, Moon RC and Pezzuto JM: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220, 1997.
19. Turcotte G, Chapdelaine A, Roberts KD and Chevalier S: Androgen binding as evidenced by a whole cell assay system using cultured canine prostate epithelial cells. J Steroid. Biochem 29: 69-76, 1988.
20. Wang LG, Liu XM, Kreis W and Butman DR: Involvement of prostate specific antigen in the stimulation of LNCaP cell growth. Oncol Rep 3: 911-917, 1996.