De novo adipose tissue generation through long-term, local delivery of insulin and insulin-like growth factor-1 by PLGA/PEG microspheres in an in vivo rat model: A novel concept and capability

Plastic and Reconstructive Surgery

Volumn 105, Issue 5, 2000, Pages 1721-1729

  Yuksel, Eser ^a   Weinfeld, Adam B ^a   Cleek, Robert ^a   Waugh, Jacob M ^a   Jensen, John ^a   Boutros, Sean ^a   Shenaq, Saleh M ^a   Spira, Melvin ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MACROGOL; MICROSPHERE; POLYGLACTIN; SOMATOMEDIN C;

ABDOMINAL WALL; ADIPOSE TISSUE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; FEMALE; HISTOGENESIS; HISTOLOGY; IMAGE ANALYSIS; KINETICS; NONHUMAN; OPTICAL DENSITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; TISSUE DIFFERENTIATION;

EID: 0034073109     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-200004050-00018     Document Type: Article

References (21)

1. Kirkland, J. L., Hollenberg, C. H., Kindler, S., and Gillon, W. S. Effects of age and anatomic site on preadipocyte number in rat fat deposits. J. Gerontol. 49: 31, 1994.
2. Shillabeer, G., and Lau, D. C. Regulation of new fat formation in rats: The role of dietary fats. J. Lipid Res. 35: 592, 1994.
3. Bjorntorp, P., Karlsson, M., Pertoft, H., et al. Isolation and characterization of cells from rat adipose tissue developing into adipocytes. J. Lipid Res. 19: 316, 1978.
4. Green, H., and Meuth, M. An established pre-adipose cell line and its differentiation in culture. Cell 3: 127, 1974.
5. Van, R. L. R., and Roncari, D. A. K. Complete differentiation of adipocyte precursors: A culture system for studying the cellular nature of adipose tissue. Cell. Tissue Res. 195: 317, 1978.
6. Porras, A., and Santos, E. The insulin/Ras pathways of adipocytic differentiation of 3T3 L1 cells: Dissociation between Raf-1 kinase a MAPK/RSK cascade. Int. J. Obes. Relat. Metab. Disord. 20 (Suppl. 3): S43, 1996.
7. Boney, C. M., Moats-Staats, B. M., Stiles, A. D., and D'Ercole, A. J. Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding proteins during adipogenesis. Endocrinology 135: 1863, 1994.
8. Brownsey, R. W., Edgell, N. J., Hopkirk, T. J., and Denton, R. M. Studies on insulin stimulated phosphorylation of acetyl CoA carboxylases, ATP citrate lyase and other proteins in rate epididymal adipose tissue. Biochem. J. 218: 733, 1981.
9. Fawcett, D. W. Histological observations on the relation of insulin to the deposition of glycogen in adipose tissue. Endocrinology 42: 454, 1948.
10. Renold, A. E., Marble, A., and Fawcett, D. W. Action of insulin on deposition of glycogen and storage of fat in adipose tissue. Endocrinology 46: 55, 1950.
11. Barak, A., Har-Shai, Y., Ullmann, Y., and Hirshowitz, B. Insulin-induced lipohypertrophy treated by liposuction. Ann. Plast. Surg. 37: 415, 1996.
12. Chajchir, A., Benzaquen, I., and Moretti, E. Comparative experimental study of autologous adipose tissue processed by different techniques. Aesthetic Plast. Surg. 17: 113, 1993.
13. Moscona, R., Shoshani, O., Lichtiq, H., and Karnieli, E. Viability of adipose tissue injected and treated by different methods: An experimental study in the rat. Ann. Plast. Surg. 33: 500, 1994.
14. Gradus-Pizlo, I., Wilensky, R. L., March, K. L., et al. Local delivery of biodegradable microparticles containing cochicine or a colchicine analogue: Effects on restenosis and implications for catheter-based drug delivery. J. Am. Coll. Cardiol. 26: 1549, 1995.
15. Heinrich, N., Fechner, K., Berger, H., et al. In-vivo release of a GnRH agonist from a slow-release poly(lacticde-glycolide) copolymer preparation: Comparison in rat, rabbit and guinea-pig. J. Pharm. Pharmacol. 43: 762, 1991.
16. Hinton, J. L., Jr., Warejcka, D. J., Mei, Y., et al. Inhibition of epidural scar formation after lumbar laminectomy in the rat. Spine 20: 564, 1995.
17. Kruisbrink, J., and Boer, G. J. Controlled long-term release of small peptide hormones using a new microporous polypeptide polymer: Its application for vasopressin in the Brattleboro rat and potential perinatal use. J. Pharm. Sci. 73: 1713, 1984.
18. Shih, C., Higuchi, T., and Himmelstein, K. J. Drug delivery from catalysed erodible polymeric matrices of poly(orthoester)s. Biomaterials 5: 237, 1984.
19. Cleek, R. L., Rege, A. A., Denner, L. A., Eskin, S. G., and Mikos, A. G. Inhibition of smooth muscle cell growth in vitro by antisense oligodeoxynucleotide released from poly(DL-lactic-co-glycolic acid) microparticles. J. Biomed. Mater. Res. 35: 525, 1997.
20. Yuksel, E., Weinfeld, A. B., Cleek, R., et al. Augmentation of adiposo-fascial flaps using the long-term local delivery of insulin and insulin-like growth factor-1. Submitted for publication.
21. Yuksel, E., Weinfeld, A. B., Cleek, R., et al. Increased free fat-graft survival with the long-term, local delivery of insulin, insulin-like growth factor-I, and basic fibroblast growth factor by PLGA/PEG microspheres. Plast. Reconstr. Surg. 105: 1712, 2000.