Inhaled salbutamol for wheezy infants: A randomised controlled trial

Archives of Disease in Childhood

Volumn 82, Issue 5, 2000, Pages 370-375

  Chavasse, R J ^a   Bastian Lee, Y ^a   Richter, H ^a   Hilliard, T ^a   Seddon, P ^a  

^a ALEXANDRA HOSPITAL   (United Kingdom)

Author keywords

Diary score; Persistent wheeze; Pulmonary function test

Indexed keywords

BRONCHODILATING AGENT; PLACEBO; SALBUTAMOL;

ARTICLE; ATOPY; BRONCHODILATATION; CHILDHOOD DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; INFANT; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; WHEEZING;

ADMINISTRATION, INHALATION; ALBUTEROL; BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FORCED EXPIRATORY FLOW RATES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INFANT; INFANT, NEWBORN; LUNG COMPLIANCE; MEDICAL RECORDS; RESPIRATORY SOUNDS;

EID: 0034071972     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.82.5.370     Document Type: Article

References (24)

1. 1 Silverman M. Out of the mouths of babes and sucklings: lessons from early childhood asthma. Thorax 1993;48:1200-4.
2. 2 Martinez FD, Wright AL, Taussig L, Holberg CJ, Halonen M, Morgan W. Asthma and wheezing in the first six years of life. N Engl J Med 1995;332:133-8.
3. 3 Chavasse R, Seddon P, Bastian-Lee Y. Preferences of bronchodilator to treat infant wheeze - a regional survey [abstract]. Eur Respir J 1999;14(suppl 30):178s.
4. 4 Rutter N, Milner AD, Hiller EJ. Effect of bronchodilators on respiratory resistance in infants and young children with bronchiolitis and wheezy bronchitis. Arch Dis Child 1975;50:719-22.
5. 5 Klassen TP, Rowe PC, Sutcliffe T, Ropp LJ, McDowell IW, Li MM. Randomized trial of salbutamol in acute bronchiolitis. J Pediatr 1991;118:807-11.
6. 6 Spier SP, Lapierre JG, Lamarre A. Response to salbutamol during a 1st or 2nd episode of wheezing in infancy [abstract]. Am Rev Respir Dis 1985;101:A259.
7. 7 Prendiville A, Rose A, Maxwell DL, Silverman M. Hypoxemia in wheezy infants after bronchodilator treatment. Arch Dis Child 1987;62:997-1000.
8. 8 Ho L, Collis G, Landau LI, Le Souef PN. Effect of salbutamol on oxygen saturation in bronchiolitis. Arch Dis Child 1991;66:1061-4.
9. 9 Radford M. Effect of salbutamol in infants with wheezy bronchitis. Arch Dis Child 1975;50:535-8.
10. 10 O'Callaghan C, Milner AD, Swarbrick A. Paradoxical deterioration in lung function after nebulised salbutamol in wheezy infants. Lancet 1986;11:1424-5.
11. 11 Prendiville A, Green S, Silverman M. Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves. Thorax 1987;42:86-91.
12. 12 Sly PD, Lanteri CJ, Raven JM. Do wheezy infants recovering from bronchiolitis respond to inhaled salbutamol. Pediatr Pulmonol 1991;10:36-9.
13. 13 Prendiville A, Green S, Silverman M. Airway responsiveness in wheezy infants: evidence for functional beta-adrenergic receptors. Thorax 1987;42:100-4.
14. 14 O'Callaghan C, Milner AD, Swarbrick A. Nebulised salbutamol does have a protective effect on airways in children under 1 year old. Arch Dis Child 1988;63:479-83.
15. 15 Tal A, Bavilski C, Yohai D, Bearman JE, Gorodischer R, Moses SW. Dexamethasone and salbutamol in the treatment of acute wheezing in infants. Pediatrics 1983;71:13-18.
16. 16 Fox GF, Marsh MJ, Milner AD. Treatment of recurrent acute wheezing episodes in infancy with oral salbutamol and prednisolone. Eur Respir J 1996;155:512-16.
17. 17 Richter H, Seddon P. Early nebulised budesonide in the treatment of bronchiolitis and the prevention of postbronchiolitic wheezing. J Pediatr 1998;132:849-53.
18. 18 Fletcher ME, Baraldi E, Steinbrugger B. Passive respiratory mechanics. In: Stocks J, Sly PD, Tepper RS, Morgan WJ, editors. Infant respiratory function testing. New York: Wiley-Liss, 1996:283-327.
19. 19 Le Souef PN, Castile R, Turner DJ, et al. Forced expiratory manoeuvres. In: Stocks J, Sly PD, Tepper RS, Morgan WJ, editors. Infant respiratory function testing. New York: Wiley-Liss, 1996:379-409.
20. 20 Clarke JR, Aston H, Silverman M. Delivery of salbutamol by metered dose inhaler and valved spacer to wheezy infants: effect on bronchial responsiveness. Arch Dis Child 1993;69: 125-9.
21. 21 Henderson AJW, Young S, Stick SM, Landau LI, Le Souef PN. Effect of salbutamol on histamine induced broncho-constriction in healthy infants. Thorax 1993;48:317-23.
22. 22 Hughes DM, Le Souef PN, Landau LI. Effect of salbutamol on respiratory mechanics in bronchiolitis. Paediatr Res 1987;22:83-6.
23. 23 Yuksel B, Greenough A. Comparison of the effects on lung function of two methods of bronchodilator administration. Respir Med 1994;88:229-33.
24. 24 Gibson NA, Ferguson AE, Aitchison TC, Paton J. Compliance with inhaled asthma medication in preschool children. Thorax 1995;50:1274-9.