A unique second donor splice site in the intron 5 sequence of the HLA-A*11 alleles results in a class I transcript encoding a molecule with an elongated cytoplasmic domain

Tissue Antigens

Volumn 55, Issue 5, 2000, Pages 422-428

  Tijssen, H J ^a   Sistermans, E A ^a   Joosten, I ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

A11; Alternative splicing; Class I antigen; HLA; MHC; Sequencing

Indexed keywords

HLA A ANTIGEN; PROTEIN KINASE C;

ALLELE; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; DENSITOMETRY; DNA SEQUENCE; EPSTEIN BARR VIRUS; EXON; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IMMUNOGENETICS; INTRON; MONONUCLEAR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS CELL TRANSFORMATION;

ALLELES; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; B-LYMPHOCYTES; CELL LINE, TRANSFORMED; CYTOPLASM; FEMALE; GENE EXPRESSION REGULATION; HLA-A ANTIGENS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RNA SPLICE SITES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

HUMAN HERPESVIRUS 4;

EID: 0034070861     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2000.550504.x     Document Type: Article

References (31)

1. 1. Bodmer JG, Marsh SGE, Albert ED et al. Nomenclature for factors of the HLA system, 1998. Eur J Immunogenet 1999: 26: 81-116.
2. 2. Ciccone E, Pende D.Viale O et al. Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2). J Exp Med 1992: 176: 963-71.
3. 3. Storkus WJ, Alexander J, Payne JA, Dawson JR, Cresswell P. Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes. Proc Natl Acad Sci U S A 1989: 86: 2361-4.
4. 4. N'Guyen C, Sodoyer R, Trucy J, Strachan T, Jordan BR. The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes. Immunogenetics 1985: 21: 479-89.
5. 5. Koller BH, Orr HT. Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level. J Immunol 1985: 134: 2727-33.
6. 6. Senju S, Kimura A, Yasunami M et al. Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene. Immunogenetics 1992: 36: 319-25.
7. 7. Tsukamoto K, Yasunami M, Kimura A et al. DQw1 beta gene from HLA-DR2-Dw12 consists of six exons and expresses multiple DQw1 beta polypeptides through alternative splicing. Immunogenetics 1987: 25: 343-6.
8. 8. Woulfe SL, Rice K, Didier DK et al. Evidence for heterogeneity of the DPA and DPB alleles derived from a DRw11,DQw7,DPw4 cell line. Hum Immunol 1989: 26: 39-45.
9. 9. Ishitani A, Geraghty DE. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. Proc Natl Acad Sci U S A 1992: 89: 3947-51.
10. 10. Huang F, Yamaguchi A, Tsuchiya N et al. Induction of alternative splicing of HLA-B27 by bacterial invasion. Arthritis Rheum 1997: 40: 694-703.
11. 11. Krangel MS. Unusual RNA splicing generates a secreted form of HLA-A2 in a mutagenized B lymphoblastoid cell line. EMBO J 1985: 4: 1205-10.
12. 12. Yang D, Le J. Targeted amplification of alternatively spliced transcripts of major histocompatibility complex class I heavy chain. J Immunol Methods 1994: 176: 265-70.
13. 13. Laforet M, Froelich N, Parissiadis A, Bausinger H, Pfeiffer B, Tongio MM. An intronic mutation responsible for a low level of expression of an HLA-A*24 allele. Tissue Antigens 1997: 50: 340-6.
14. 14. Magor KE, Taylor EJ, Shen SY et al. Natural Inactivation of a common HLA allele (A*2402) has occurred on at least three separate occasions. J Immunol 1997: 158: 5242-50.
15. 15. Abu hadid MM, Fuji H, Sood AK. Alternatively spliced MHC class I mRNAs show specific deletion of sequences encoding the extracellular polymorphic domains. Int Immunol 1994: 6: 323-37.
16. 16. Ellis SA, Braem KA, Morrison WI. Transmembrane and cytoplasmic domain sequences demonstrate at least two expressed bovine MHC class I loci. Immunogenetics 1992: 37: 49-56.
17. 17. Grossberger D, Hein W, Marcuz A. Class I major histocompatibility complex cDNA clones from sheep thymus: alternative splicing could make a long cytoplasmic tail. Immunogenetics 1990: 32: 77-87.
18. 18. Ennis PD, Zemmour J, Salter RD, Parham P. Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification. Proc Natl Acad Sci U S A 1990: 87: 2833-7.
19. 19. Breathnach R, Chambon P. Organization and expression of eukaryotic split genes coding for proteins. Annu Rev Biochem 1981: 50: 349.
20. 20. Strachan T, Sodoyer R, Damotte M, Jordan BR. Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes. EMBO J 1984: 3: 887-94.
21. 21. Girdlestone J. Nucleotide sequence of an HLA-A1 gene. Nucleic Acids Res 1990: 18: 6701.
22. 22. Shapiro MB, Senapathy P. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res 1987: 15: 7155-74.
23. 23. Krangel MS. Secretion of HLA-A and -B antigens via an alternative RNA splicing path way. J Exp Med 1986: 163: 1173-90.
24. 24. He X, Le J. Alternative splicing of HLA class I transcripts induced by IFN-gamma and TNF in fibroblasts: release of soluble HLA class I heavy chain and an associate protein. Cell Immunol 1995: 162: 159-68.
25. 25. Mason PM, Parham P. HLA class I region sequences, 1998. Tissue Antigens 1998: 51: 417-66.
26. 26. Reali E, Guerrini R, Giori B et al. Activation of epitope specific memory cytotoxic T lymphocyte responses by synthetic peptides. Clin Exp Immunol 1996: 105: 269-375.
27. 27. Nabavi N, Freeman GJ, Gault A, Godfrey D, Nadler LM, Glimcher LH. Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature 1992: 360: 266-8.
28. 28. St-Pierre Y, Nabavi N, Ghogawala Z, Glimcher LM, Watts T. A functional role for signal transduction via the cytoplasmic domains of MHC class II molecules. J Immunol 1989: 143: 808-12.
29. 29. Wagner N, Engel P, Vega M, Tedder TF. Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. J Immunol 1994: 152: 5275-87.
30. 30. Gur H, El-Zataari F, Geppert TD, Wacholtz MC, Taurog JD, Lipsky PE. Analysis of T cell signalling by class I MHC molecules: the cytoplasmic domain is not required for signal transduction. J Exp Med 1990: 172: 1267-70.
31. 31. Gur H, Geppert TD, Lipsky PE. Structural analysis of class I MHC molecules: the cytoplasmic domain is not required for cytoskeletal association, aggregation and internalization. Mol Immunol 1997: 34: 125-32.