Problems associated with intravenous fluid administration in children: Do we have the right solutions?

Current Opinion in Pediatrics

Volumn 12, Issue 3, 2000, Pages 217-221

  Bohn, Desmond ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROLYTE; INFUSION FLUID; SODIUM;

ARTICLE; BRAIN CELL; BRAIN EDEMA; BRAIN INJURY; COLLOID; CRITICAL ILLNESS; CRYSTALLOID; DIABETIC KETOACIDOSIS; HYPONATREMIA; INTRAVENOUS ADMINISTRATION; ONCOTIC PRESSURE; OSMOTIC PRESSURE; PRIORITY JOURNAL;

BRAIN EDEMA; CHILD; COLLOIDS; FLUID THERAPY; HUMANS; INFUSIONS, INTRAVENOUS; RISK FACTORS; WATER-ELECTROLYTE BALANCE;

EID: 0034070693     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-200006000-00007     Document Type: Article

References (38)

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38. 38 Sort P, Navasa M, Arroyo V. et al.: Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 1999, 341:403-409. A RCT of the use of albumin plus cefotaxime versus cefotaxime in 126 patients with cirrhosis and spontaneous bacterial peritonitis. The infection resolved in 59 patients in the cefotaxime group (94%) and 62 in the cefotaxime-plus-albumin group (98%, P = 0.36). Renal impairment developed in 21 patients in the cefotaxime group (33%) and in six patients in the cefotaxime-plus-albumin group (10%, P = 0.002). Eighteen patients (29%) in the cefotaxime group died in the hospital, as compared with 6 (10%) in the cefotaxime-plus-albumin group (P = 0.01). This is an important study, as it is one of the largest designed RCTs of albumin in critically ill patients. The reduction in the incidence of renal failure in the albumin group was associated with lower renin levels, implying improved renal perfusion.