Effect of cocaine on mitochondrial electron transport chain evaluated in primary ,cultures of neonatal rat myocardial cells and in isolated mitochondrial preparations

Drug and Chemical Toxicology

Volumn 23, Issue 2, 2000, Pages 339-348

  Yuan, Cai ^a,b   Acosta Jr , Daniel ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; LACTATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TETRAZOLIUM; TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ARTICLE; CARDIOTOXICITY; CELL CULTURE; CELL ISOLATION; CELL SWELLING; DRUG ABUSE; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME PURIFICATION; HEART MUSCLE CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; RAT; RESPIRATORY CHAIN; TARGET CELL;

ANIMALS; ANIMALS, NEWBORN; CELL FRACTIONATION; CELLS, CULTURED; COCAINE; ELECTRON TRANSPORT; L-LACTATE DEHYDROGENASE; MITOCHONDRIA, HEART; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS;

ANIMALIA;

EID: 0034069847     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-100100119     Document Type: Article

References (28)

1. Benowitz, N.L. Clinical pharmacology and toxicology of cocaine. Pharmacol Toxicol., 72:3, 1993.
2. Kloner, R. A, Hale, S., Alker, K. and Rezkalla, S. The effect of acute and chronic cocaine use on the heart. Circulation, 85:407, 1992.
3. Wiener, R.S., Lockhart, J.T. and Schwartz, R.G. Dilated cardiomyopathy and cocaine abuse. Am. J. Med., 81:699, 1986.
4. Peng, S.K., French, W.J. and Pelikan, P.C.D. Direct cocaine cardiotoxicity demonstrated by endomyocardial biopsy. Arch. Pathol. Lab. Med., 113:842, 1989.
5. Devi, B.G. and Chan, A.W.K. Effect of cocaine on cardiac biochemical functions. J. Cardiovasc. Pharmacol., 33:1, 1999.
6. Otani, H., Engelman, R.M. and Rousou, J.A. Enhanced prostaglanding synthesis due to phospholipids breakdown in ischemic-reperfused myocardium: control of its production by a phospholipase inhibitor or free radical scavengers. J. Mol. Cell. Cardiol., 18:953, 1986.
7. Billman, G.E. Intracellular calcium chelater, BAPTA-AM prevents cocaine-induced ventricular fibrillation. Am. J. Physiol., 265:H1529, 1993.
8. Knuepfer, M.M., Branch, C.A., Gan, Q. and Fischer, V.W. Cocaine-induced myocardial ultrastructural alterations and cardiac output responses in rats. Exp. Mol. Pathol., 59:115, 1993.
9. Vitullo, J.C., Mekhail, N.A., Estafanous, F.G., Khairallah, P.A. and Engelmann, G.L. Acute morphological effects of cocaine on rat cardiomyocytes. Cytobios, 76:31, 1993.
10. Maillet, M., Chriarasini, D. and Nahas, G. Myocardial damage induced by cocaine administration of a week's duration in the rat. Adv. Biosci., 80:187, 1991.
11. Fantel, A.G., Person, R.E., Burroughs-Gleim, C.J. and Mackler, B. Direct embrotoxicity of cocaine in rats: effects on mitochondrial activity, cardiac function, and growth and development in vitro. Teratology, 42:35, 1990.
12. Yuan, C. and Acosta, D. Cocaine-induced mitochondrial dysfunction in primary cultures of rat cardiomyocytes. Toxicology, 12:1, 1996.
13. Wenzel, D.G., Wheatley, J.W. and Byrd, G.D. Effects of nicotine on cultured rat heart cells. Toxicol. Appl. Pharmacol., 17:774, 1970.
14. Mitchell, D.B., Santone, K.S. and Acosta, D. Evaluation of cytotoxicity in cultured cells by enzyme leakage. J. Tiss. Cul. Meth., 6:113, 1980.
15. Musser, D.A. and Oseroff, A.R. The use of tetrazolium salts to determine sites of damage to the mitochondrial electron transport chain in intact cells following in vitro photodynamic therapy with photofrin II. Photochem. Photobiol., 59:621, 1994.
16. Fuller, E.O., Goldberg, D.I., Starnes, J.W., Sacks, L.M. and Delivoria-Papadopoulos, M. Mitochondrial respiration following acute hypoxia in the perfused rat heart. J Mol. Cell. Cardiol., 17:71, 1985.
17. Bradford, M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72:248, 1976.
18. Cain, K. and Skilleter, D.N. Preparation and use of mitochondria in toxicological research. Biochemical toxicology: a practical approach, 217-254, 1987.
19. Nakamura, G.R. and Noguchi, T.T. Fatalities from cocaine overdoses in Los Angeles County. Clin. Toxicol., 18:895, 1981.
20. Mittleman, R.E. and Wetli, C.V. Death caused by recreational cocaine use. J. Am. Med. Ass., 252:1889, 1984.
21. Peretti, F.J., Isenschmid, D.S., Levene, B., Calplan, Y.H. and Simalek, J.E. Cocaine fatality: an unexplained blood concentration in a fatal overdose. Forens. Sci. Int., 48:135, 1990.
22. Albuquerque, M.L. and Kurth, C.D. Cocaine constricts cerebral arterioles by a local anesthetic mechanism. Eur. J. Pharmacol., 249:215, 1993.
23. Kabas, J.S., Blanchard, S.M., Matsuyama, Y., Long, J.D., Hoffman, G.W., Ellinwood, E.H., Smith, P.K. and Strauss, H.C. Cocaine-mediated impairment of cardiac conduction in the dog: a potential mechanism for sudden death after cocaine. J. Pharmacol. Exp. Ther., 252:185, 1990.
24. Fraker, T.D., Temesy-Armos, P.N., Brewster, P.S. and Wilkerson, R.D. Mechanism of cocaine-induced myocardial depression in dogs. Circulation, 81:1012, 1990.
25. Slater, T.F., Sawyer, B. and Strauli, U. Studies on succinate-tetrazolium reductase system III. points of coupling of four different tetrazolium salts. Biochim. Biophys. Acta, 77:383, 1963.
26. Fearnley, I.M., Skehel, J.M. and Walker, J.E. Electrospray ionization mass spectrometric analysis of subunits of NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Biochem. Applic. Mass Spec., 22:551, 1994.
27. Finel, M., Skehel, J.M., Albracht, S.P.J., Fearnley, I.M. and Walker, J.E. Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme. Biochemistry, 31:11425, 1992.
28. Leon-Velarde, F., Huicho, L. and Monge C. Effects of cocaine on oxygen consumption and mitochondrial respiration in normoxic and hypoxic mice. Life Sci., 50:213, 1991.