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Volumn 52, Issue 1, 2000, Pages 27-36

Lipoxygenase inhibitor FLM 5011, an effective protectant of myocardial microvessels against ischemia-reperfusion injury? An ultrastructural- morphometric study

Author keywords

Ischemia, reperfusion; Lipoxygenase inhibitor; Microvessels, myocardial; Myocardium, microvessels

Indexed keywords

FLM 5011;

EID: 0034068340     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(00)80012-3     Document Type: Article
Times cited : (13)

References (30)
  • 1
    • 0027314324 scopus 로고
    • Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leucotriene C4
    • ALLEN SP, DASHWOOD MR, CHESTER AH et al.: Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leucotriene C4. Cardioscience 1993; 4: 47-54.
    • (1993) Cardioscience , vol.4 , pp. 47-54
    • Allen, S.P.1    Dashwood, M.R.2    Chester, A.H.3
  • 2
    • 0026024366 scopus 로고
    • Seminars in thrombosis, thrombolysis and vascular biology. 1. The vascular endothelium
    • BECKER RC: Seminars in thrombosis, thrombolysis and vascular biology. 1. The vascular endothelium. Cardiology 1991; 78: 13-22.
    • (1991) Cardiology , vol.78 , pp. 13-22
    • Becker, R.C.1
  • 3
    • 0022402059 scopus 로고
    • Myocardial reperfusion: A doble-edged sword?
    • BRAUNWALD E, KLONER RA: Myocardial reperfusion: a doble-edged sword? J Clin Invest 1985; 76: 1713-1719.
    • (1985) J Clin Invest , vol.76 , pp. 1713-1719
    • Braunwald, E.1    Kloner, R.A.2
  • 4
    • 0014091073 scopus 로고
    • Frühstadien der akuten hypoxischen veränderung des herzmuskels im elektronenmikroskopischen bild und ihre bedeutung für die akute hypoxische herzinsuffizienz
    • BÜCHNER F, ONISHI S: Frühstadien der akuten hypoxischen Veränderung des Herzmuskels im elektronenmikroskopischen Bild und ihre Bedeutung für die akute hypoxische Herzinsuffizienz. Beitr Pathol Anat 1967; 135: 153-182.
    • (1967) Beitr Pathol Anat , vol.135 , pp. 153-182
    • Büchner, F.1    Onishi, S.2
  • 6
    • 85031639665 scopus 로고    scopus 로고
    • The protective effect of Iloprost, a PGI2-analogue, on ultrastructure of ischemic and reperfused myocardial myocytes
    • FITZL G, WINKLER D, WASSILEW G, WELT K: The protective effect of Iloprost, a PGI2-analogue, on ultrastructure of ischemic and reperfused myocardial myocytes. Exp Toxic Pathol 1998; 50: 484-491
    • (1998) Exp Toxic Pathol , vol.50 , pp. 484-491
    • Fitzl, G.1    Winkler, D.2    Wassilew, G.3    Welt, K.4
  • 7
    • 0024263243 scopus 로고
    • Antiinflammatory effect of a lipoxygenase inhibitor (FLM 5011) in severe active myocarditis
    • GEISSLER W, FÖRSTER A; SCHEWE T, et al.: Antiinflammatory effect of a lipoxygenase inhibitor (FLM 5011) in severe active myocarditis. Biomed Biochim Acta 1988; 47: 311-314.
    • (1988) Biomed Biochim Acta , vol.47 , pp. 311-314
    • Geissler, W.1    Förster, A.2    Schewe, T.3
  • 8
    • 0001751004 scopus 로고
    • 2-Radikale) bei hypoxie und ischämie
    • 2-Radikale) bei Hypoxie und Ischämie. Z Klin Med 1987; 42: 1025-1029.
    • (1987) Z Klin Med , vol.42 , pp. 1025-1029
    • Gerber, G.1    Siems, W.2
  • 10
    • 84939582514 scopus 로고
    • Zum feinbau der endstrombahnen und ihres inhalts nach ischämie und reperfusion
    • HAMMERSEN F, MESSMER K (eds.): Konstanz/Bodensee 26.-27 Juni 1987. Karger Basel
    • HAMMERSEN F; BARKNER JH, GIDLÖF A, et al.: Zum Feinbau der Endstrombahnen und ihres Inhalts nach Ischämie und Reperfusion.In: HAMMERSEN F, MESSMER K (eds.): Berichte des 7. Bodensee-Symposiums über Mikrozirkulation. Konstanz/Bodensee 26.-27 Juni 1987. Karger Basel 1987: 1-27.
    • (1987) Berichte des 7. Bodensee-Symposiums Über Mikrozirkulation , pp. 1-27
    • Hammersen, F.1    Barkner, J.H.2    Gidlöf, A.3
  • 11
    • 0027183768 scopus 로고
    • The myocardial vasculature during ischemia and reperfusion: A target for injury and protection
    • HEARSE DJ, MAXWELL L, SALDANHA C, GAVIN JB: The myocardial vasculature during ischemia and reperfusion: a target for injury and protection. J Mol Cell Cardiol 1993; 25: 759-800.
    • (1993) J Mol Cell Cardiol , vol.25 , pp. 759-800
    • Hearse, D.J.1    Maxwell, L.2    Saldanha, C.3    Gavin, J.B.4
  • 12
    • 85031641734 scopus 로고    scopus 로고
    • Die ultrastruktur myokardialer gefäße und nerven in operativ gewonnenen gewebeproben
    • Gießen
    • KREISEL EC: Die Ultrastruktur myokardialer Gefäße und Nerven in operativ gewonnenen Gewebeproben. Med Diss, Gießen (1982).
    • Med Diss , pp. 1982
    • Kreisel, E.C.1
  • 13
    • 0023707013 scopus 로고
    • Endothelial cells of the cardiac microvasculature during and after cold cardioplegic ischaemia. Comparison of endothelial and myocyte damage
    • LINDAL S, SORLIE D, JORGENSEN L: Endothelial cells of the cardiac microvasculature during and after cold cardioplegic ischaemia. Comparison of endothelial and myocyte damage. Scand J Thorac Cardiovasc Surg 1988; 22: 257-265.
    • (1988) Scand J Thorac Cardiovasc Surg , vol.22 , pp. 257-265
    • Lindal, S.1    Sorlie, D.2    Jorgensen, L.3
  • 15
    • 0030031239 scopus 로고    scopus 로고
    • Hypotheses regarding the role of pericytes in regulating movement of fluids, nutrients, and hormones across the microcirculatory endothelial barrier
    • LONIGRO AJ, MCMURDO L, STEPHENSON AH, et al.: Hypotheses regarding the role of pericytes in regulating movement of fluids, nutrients, and hormones across the microcirculatory endothelial barrier. Diabetes 1996; 45, Suppl 1: 38-43.
    • (1996) Diabetes , vol.45 , Issue.SUPPL. 1 , pp. 38-43
    • Lonigro, A.J.1    McMurdo, L.2    Stephenson, A.H.3
  • 16
    • 85047681024 scopus 로고
    • The contribution of ischaemia to the development of microvascular incompetence in the myocardium
    • MAXWELL L, GAVIN JB: The contribution of ischaemia to the development of microvascular incompetence in the myocardium. Cardiovasc Res 1991; 25: 491-495.
    • (1991) Cardiovasc Res , vol.25 , pp. 491-495
    • Maxwell, L.1    Gavin, J.B.2
  • 18
    • 0005976895 scopus 로고
    • Störungen der zellulären und extrazellulären organisation
    • RIEDE UN, SCHAEFER HE, WEHNER H (eds.): 2. Aufl. Thieme, Stuttgart, New York
    • RIEDE UN, ROHRBACH R, SCHAEFER HE, MÜLLER HJ: Störungen der zellulären und extrazellulären Organisation. In: RIEDE UN, SCHAEFER HE, WEHNER H (eds.): Allgemeine und spezielle Pathologie, 2. Aufl. Thieme, Stuttgart, New York 1989, pp. 7-80.
    • (1989) Allgemeine und Spezielle Pathologie , pp. 7-80
    • Riede, U.N.1    Rohrbach, R.2    Schaefer, H.E.3    Müller, H.J.4
  • 20
    • 0020085325 scopus 로고
    • The effects of global ischaemia and reperfusion on human myocardium; quantitative evaluation by electron microscopic morphometry
    • SCHAPER J, SCHWARZ F, KITTSTEIN H, et al.: The effects of global ischaemia and reperfusion on human myocardium; quantitative evaluation by electron microscopic morphometry. Ann Thoracic Surg, Boston 1982; 33: 115-122.
    • (1982) Ann Thoracic Surg, Boston , vol.33 , pp. 115-122
    • Schaper, J.1    Schwarz, F.2    Kittstein, H.3
  • 21
    • 84939581631 scopus 로고    scopus 로고
    • Institut für Biochemie der Humboldt-Universität Berlin (1990), unpublished (available at FILT Forschungsgemeinschaft für Lungen und Thoraxerkrankungen mbH, Karower Str. 11/205, 13125 Berlin-Buch)
    • SCHEWE T: Zuarbeit zum pharmakologischen Hauptwirkungsgutachten für FLM 5011. Institut für Biochemie der Humboldt-Universität Berlin (1990), unpublished (available at FILT Forschungsgemeinschaft für Lungen und Thoraxerkrankungen mbH, Karower Str. 11/205, 13125 Berlin-Buch).
    • Zuarbeit zum Pharmakologischen Hauptwirkungsgutachten für FLM 5011
    • Schewe, T.1
  • 23
    • 0022967405 scopus 로고
    • Pure enzymes in a test hierarchy for bronchoconstrictory Hp-oxygenase inhibitors
    • SLAPKE J, SCHEWE T, KÜHN H, RAPOPORT SM: Pure enzymes in a test hierarchy for bronchoconstrictory Hp-oxygenase inhibitors. Biomed Biochim Acta 1986; 45: 1267-1275.
    • (1986) Biomed Biochim Acta , vol.45 , pp. 1267-1275
    • Slapke, J.1    Schewe, T.2    Kühn, H.3    Rapoport, S.M.4
  • 24
    • 84939579945 scopus 로고    scopus 로고
    • Martin-Luther-Universität Halle-Wittenberg (1987), unpublished (available at FILT Forschungsgemeinschaft für Lungen und Thoraxerkrankungen mbH, Karower Str. 11/205, 13125 Berlin-Buch)
    • SZIEGOLEIT W: Obergutachten zum Antrag auf Prüfung des neuen Lipoxygenasehemmers FLM 5011 (früher F5) am Menschen (Stufe I). Martin-Luther-Universität Halle-Wittenberg (1987), unpublished (available at FILT Forschungsgemeinschaft für Lungen und Thoraxerkrankungen mbH, Karower Str. 11/205, 13125 Berlin-Buch).
    • Obergutachten zum Antrag auf Prüfung des Neuen Lipoxygenasehemmers FLM 5011 (Früher F5) am Menschen (Stufe I)
    • Sziegoleit, W.1
  • 26
    • 0029035130 scopus 로고
    • Endothelial cell "swelling" in ischaemia and reperfusion
    • WARD BJ, MCCARTHY A: Endothelial cell "swelling" in ischaemia and reperfusion. J Mol Cell Cardiol 1995; 27: 1293-1300.
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 1293-1300
    • Ward, B.J.1    McCarthy, A.2
  • 27
    • 0031105055 scopus 로고    scopus 로고
    • Antioxidants attenuate postischemic endothelial cell swelling and luminal membrane blebbing in cardiac capillaries
    • WARD BJ, SCOOTE M, Antioxidants attenuate postischemic endothelial cell swelling and luminal membrane blebbing in cardiac capillaries. Microvasc Res 1997; 53: 179-186.
    • (1997) Microvasc Res , vol.53 , pp. 179-186
    • Ward, B.J.1    Scoote, M.2
  • 28
    • 0031595298 scopus 로고    scopus 로고
    • 2O-induced hypoxia as a model of hypoxic stress of rat myocardium. An ultrastructural-morphometric study
    • 2O-induced hypoxia as a model of hypoxic stress of rat myocardium. An ultrastructural-morphometric study. Exp Toxic Pathol 1998; 50: 229-237.
    • (1998) Exp Toxic Pathol , vol.50 , pp. 229-237
    • Welt, K.1    Schaffranietz, L.2    Lukas, H.3
  • 30
    • 0024405445 scopus 로고
    • Myocardial infarction in rats: Effects of metabolic and pharmacologic interventions
    • ZIMMER HG, MARTIUS PA, MARSCHNER G: Myocardial infarction in rats: effects of metabolic and pharmacologic interventions. Basic Res Cardiol 1989; 84: 332-343.
    • (1989) Basic Res Cardiol , vol.84 , pp. 332-343
    • Zimmer, H.G.1    Martius, P.A.2    Marschner, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.