Synthesis and preliminary pharmacological evaluation of new 6-cyano-2,3- dihydro-5H-oxazolo[3,2-a]pyrimidin-5-ones and 2-ethyl(methylenecyanoacetate)- 2-iminooxazolidines

Pharmacy and Pharmacology Communications

Volumn 6, Issue 2, 2000, Pages 101-105

  Chaimbault, C ^a   Bosc, J J ^a   Jarry, C ^a   Daulouede, S ^b   Vincendeau, P ^b  

^a Laboratoire de Pharmacochimie   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL(METHYLENECYANOACETATE) 2 IMINOOXAZOLIDINE; 6 CYANO 2,3 DIHYDRO 5H OXAZOLO[3,2 A]PYRIMIDIN 5 ONE; ANTIPARASITIC AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; CONFERENCE PAPER; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; MOUSE; NONHUMAN; REACTION ANALYSIS;

EID: 0034068243     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080800128735719     Document Type: Conference Paper

References (10)

1. Adetchessi, O., Desor, D., Forfar, I., Jarry, C., Leger, J. M., Laguerre, M., Carpy, A. (1997) Reaction of 5-substituted 2-amino-2-oxazolines with ethoxycarbonylisocyanate. A route to 2,3,6,7-tetrahydro-4H-oxazolo[3,2-a]-1,3,5-triazine-2,4-diones. J. Heterocyclic Chem. 34: 429-434
2. Bosc, J. J., Forfar, I., Jarry, C. (1997) Synthesis of 2,3,6,7-tetrahydro-7-methoxymethyl-4H-oxazolo[3,2-a]-1,3,5-triazin-2,4-diones as potential anti-inflammatory agents. Pharm. Sci. 3: 291-293
3. Brown, D. J. (1962) The Pyrimidines,Wiley-Interscience, New York, Suppl. 1970
4. Chaimbault, C., Bosc, J. J., Jarry, C., Leger, J. M., Marchand-Geneste, N., Carpy, A. (1999) Structural and theoretical evidence of the reaction products of ethyl (ethoxymethylene)-cyanoacetate with 5-phenoxymethyl-2-amino-2-oxazoline. J. Mol. Struct. 508: 193-205
5. Duran, N., Campos, V., Riveros, R., Joyas, A., Pereira, M. F., Haun, M. (1989) Bacterial chemistry - III: preliminary studies on trypanosomal activities of Chromobacterium violaceum products. Ann. Acad. Bras. Cienc. 61: 31-36
6. Haun, M., Pereira, M. F., Hoffmann, M. E., Joyas, A., Campos, V., Filardi, L. D., de Castro, S. L., Duran, N. (1992) Bacterial chemistry. VI. Biological activities and cytotoxicity of 1,3-dihydro-2H-indol-2-one derivatives. Biol. Res. 25: 21-25
7. Jarry C., Golse, R., Pancans, E., Creuzet, M. H. (1986) Synthesis and pharmacological properties of some S-dialkyl-anunomethyl-2-amino-2-oxazolines. Eur. J. Med. Chem. 21: 138-142
8. Jarry, C., Forfar, I., Thomas, J., Leger, J. M., Laguerre, M. (1993) Reaction of 5-substituted 2-amino-2-oxazolines with ethoxycarbonylisothiocyanate. Heterocycles 36: 2465-2473
9. Loiseau, P. M., Dreyfuss, G., Daulouede, S., Lachatre, G., Vincendeau, P., Craciunescu, D. G. (1997) Trypanocidal effect of Ir-(COD)-pentamidine tetraphenylborate on Trypanosoma brucei and T. b. gambiense rodent models and serum kinetics in sheep. Trop. Med. Intern. Hlth. 2: 19-27
10. Vasudevan, A., Mavandadi, F., Chen, L., Gangjee, A. (1999) Reactions of 6-aminopyrimidines with bis electrophiles: manipulation of product composition with solvent and pyrimidine substitution variation. J. Org. Chem. 64: 634-638