In vitro binding and partitioning of irinotecan (CPT-11) and its metabolite, SN-38, in human blood

Investigational New Drugs

Volumn 18, Issue 1, 2000, Pages 1-5

  Combes, Olivier ^a   Barré, Jérôme ^a   Duché, Jean Claude ^a   Vernillet, Laurent ^b   Archimbaud, Yves ^b   Marietta, Michael P ^b   Tillement, Jean Paul ^a   Urien, Saïk ^a,c  

^a FACULTÉ DE MÉDECINE   (France)

^b SANOFI   (France)

^c INSERM   (France)

Author keywords

Anticancer drugs; Blood binding; Blood cells; CPT 11; Irinotecan; Platelets; Protein binding; SN 38

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ALBUMIN; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN; IRINOTECAN; LOW DENSITY LIPOPROTEIN; PLASMA PROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; ERYTHROCYTE; HUMAN; LYMPHOCYTE; NEUTROPHIL; PH; PRIORITY JOURNAL; THROMBOCYTE; ULTRAFILTRATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOOD CELL COUNT; BLOOD CELLS; BLOOD PLATELETS; BLOOD PROTEINS; CAMPTOTHECIN; HUMANS; PROTEIN BINDING; ULTRAFILTRATION;

EID: 0034068213     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006379730137     Document Type: Article

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