Evalaution of biologically based dose-response modeling for developmental toxicity: A workshop report

Regulatory Toxicology and Pharmacology

Volumn 31, Issue 2 I, 2000, Pages 190-199

  Lau, Christopher ^a   Andersen, Melvin E ^b   Crawford Brown, Douglas J ^c   Kavlock, Robert J ^a   Kimmel, Carole A ^d   Knudsen, Thomas B ^e   Muneoka, Ken ^f   Rogers, John M ^a   Setzer, R Woodrow ^a   Smith, Gary ^g   Tyl, Rochelle ^h  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b ICF INTERNATIONAL   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f TULANE UNIVERSITY   (United States)

^g GLAXOSMITHKLINE   (United States)

^h NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; TERATOGENIC AGENT;

DOSE RESPONSE; HEALTH HAZARD; MATHEMATICAL MODEL; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TOXICITY TESTING; ANIMAL; BIOLOGICAL MODEL; CONFERENCE PAPER; CONGENITAL MALFORMATION; DRUG SURVEILLANCE PROGRAM; EDUCATION; GOVERNMENT; HUMAN; METHODOLOGY; UNITED STATES;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDUCATION; FLUOROURACIL; HUMANS; MODELS, BIOLOGICAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RISK ASSESSMENT; TERATOGENS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 0034066744     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1999.1360     Document Type: Article

References (28)

1. H.A. Barton M.E. Andersen H.J. Clewell III Harmonization: Developing consistent guidelines for applying mode of action and dosimetry information to cancer and noncancer risk assessment Hum. Ecol. Risk Assess. 4 1998 75 115
2. C.P. Dagg Sensitive stages for the production of developmental abnormalities in mice with 5-fluorouracil Am. J. Anat. 106 1960 89 96
3. K.H. Elstein R.M. Zucker D.L. Shuey C. Lau N. Chernoff J.M. Rogers Utility of the murine erythroleukemic cells (MELC) in assessing mechanisms of action of DNA-active developmental toxicants: Application to 5-fluorouracil Teratology 48 1993 75 87
4. K.H. Elstein M.L. Mole R.W. Setzer R.M. Zucker R.J. Kavlock J.M. Rogers C. Lau Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells Toxicol. Appl. Pharmacol. 146 1997 29 39
5. D. Fell Understanding the Control of Metabolism 1997 Portland Press London
6. F. Heinmets Supercomputer analysis of purine and pyrimidine metabolism leading to DNA synthesis Cell Biophys. 14 1989 283 323
7. F. Heinmets R.H. Leary A study of deoxyribonucleotide metabolism and its relation to DNA synthesis Cell Biophys. 17 1992 263 277
8. R.C. Jackson A kinetic model of regulation of the deoxyribonucleoside triphosphate pool composition Pharmacol. Ther. 24 1984 279 301
9. D.A. Karnofsky M.L. Murphy C.R. Lacon Comparative toxicologic and teratologic effects of 5-fluoro-substituted pyrimidines in the chick embryos and pregnant rat Proc. Am. Assoc. Cancer Res. 2 1958 312 313
10. Lau, C, Mole, M. L, Copeland, M. F, Rogers, J. M, Kavlock, R. J, Shuey, D. L, Cameron, A. M, Ellis, D. H, Merriman, J, and, Setzer, R. W. 1999, Toward building a biologically based dose–response model for developmental toxicity of 5-fluorouracil in the rat: Acquisition of experimental data. Submitted for publication.
11. M.L. Mole D.L. Hunter P. Gao C. Lau Sample preparation and high-performance liquid chromatographic analysis of deoxyribonucleoside triphosphates in individual rat embryos Anal. Biochem. 259 1998 245 252
12. K. Muneoka R. Anderson Vertebrate limb development R.J. Kavlock G.P. Daston Drug Toxicity in Embryonic Development 1997 Springer-Verlag Berlin 41 75
13. E.J. O'Flaherty Pharmacokinetics, pharmacodynamics, and prediction of developmental abnormalities Reprod. Toxicol. 11 1997 413 416
14. J. Ovadi Physiological significance of metabolic channelling J. Theor. Biol. 152 1991 1 22
15. W.B. Parker Y.C. Cheng Metabolism and mechanism of action of 5-fluorouracil Pharmacol. Ther. 48 1991 381 395
16. H.M. Pinendo G.F.J. Peters Fluorouracil: Biochemistry and pharmacology J. Clin. Oncol. 6 1988 1653 1664
17. R.W. Setzer Development of biologically-based dose–response models: Modeling the effects of 5-FU on cell cycle kinetics Teratology 47 1993 435 436
18. Setzer, R. W, Lau, C, Copeland, F. M, Mole, M. L, Rogers, J. M, and, Kavlock, R. J. 1999, Toward building a biologically based dose–response model for developmental toxicity of 5-fluorouracil in the rat: Modeling nucleotide pool perturbation. Submitted for publication.
19. R.M. Shah R.A. MacKay Teratological evaluation of 5-fluorouracil and 5-bromo-2-deoxyuridine on hamster fetuses J. Embryol. Exp. Morphol. 57 1978 119 128
20. D.L. Shuey C. Lau T.R. Logsdon R.M. Zucker K.H. Elstein M.G. Narotsky R.W. Setzer R.J. Kavlock J.M. Rogers Biologically based dose–response modeling in developmental toxicology: Biochemical and cellular sequelae of 5-fluorouracil exposure in the developing rat Toxicol. Appl. Pharmacol. 126 1994 129 144
21. D.L. Shuey R.M. Zucker K.H. Elstein J.M. Rogers Fetal anemia following maternal exposure to 5-fluorouracil in the rat Teratology 49 1994 311 319
22. D.L. Shuey A.R. Buckalew T.S. Wilke J.M. Rogers B.D. Abbott Early events following maternal exposure to 5-fluorouracil lead to dysmorphology in cultured embryonic tissues Teratology 50 1994 379 386
23. J.D. Stephens M.S. Golbus T.R. Miller R.R. Wilber C.J. Epstein Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester Am. J. Obstet. Gynecol. 137 1980 747 749
24. W.C. Werkheiser G.B. Grindey R.G. Moran C.A. Nichol Mathematical simulation of the interaction of drugs that inhibit deoxyribonucleic acid biosynthesis Mol. Pharmacol. 9 1973 320 329
25. J.G. Wilson Use of rhesus monkeys in teratological studies Fed. Proc. 30 1971 104 109
26. J.G. Wilson Environment and Birth Defects 1973 Academic Press New York
27. E.F. Zimmerman Palate R.J. Kavlock G.P. Daston Drug Toxicity in Embryonic Development 1997 Springer-Verlag Berlin 183 208
28. R.M. Zucker K.H. Elstein D.L. Shuey J.M. Rogers Flow cytometric detection of abnormal fetal erythropoiesis: Application to 5-fluorouracil-induced anemia Teratology 51 1995 37 44