Effect of stabilizing versus destabilizing interactions on plasminogen activator inhibitor-1

Journal de Pharmacie de Belgique

Volumn 55, Issue 2, 2000, Pages 57-58

  Vleugels, Nele ^a   Leys, John ^a   Knockaert, Isabelle ^a   Declerck, Paul J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ARTICLE; DRUG CONFORMATION; DRUG HALF LIFE; DRUG INACTIVATION; DRUG STABILITY; ENZYME CONFORMATION; ENZYME SUBSTRATE; MUTATION;

PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS;

EID: 0034066722     PISSN: 00472166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Vaughan, D.E. & Declerck, P.J. (1998) Fibrinolysis and its regulation. Thrombosis and hemorrhage (ed. by Loscalzo and Schafer), p. 155. Williams & Wikins,
2. Gils, A., Lu, J., Aertgeerts, K., Knockaert, I., and Declerck, P. J. (1997) Identification of positively charged residues contributing to the stability of plasminogen activator inhibitor l. FEBS Lett. 415, 192-195
3. Vleugels, N., Gils, A., Mannaerts, S., Knockaert, I. & Declerck, P.J. (1998) Evaluation of the mechanism of inactivation of plasminogen activator inhibitor-1 by monoclonal antibodies using a stable variant. Fibrinolysis & Proteolysis, 12, 277-282.