The role of the route of administration of poly-chlorinated biphenyls (PCBs) on the reproductive and vital organs of adult female rats

Biomedical Sciences Instrumentation

Volumn 36, Issue , 2000, Pages 159-164

  Blake, Kevin ^a   Benghuzzi, Hamed ^a   Cason, Zelma ^a   Tsao, Audrey ^a   Puckett, Aaron ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Bioceramics; Estrus cycle; Polychlorinated biphenyls; Reproductive tract; Sustained delivery system

Indexed keywords

CERAMIC MATERIALS; IMPLANTS (SURGICAL); PHOSPHATE MINERALS; POLYCHLORINATED BIPHENYLS; TISSUE;

TRICALCIUM PHOSPHATE LYSINE;

CONTROLLED DRUG DELIVERY;

AROCLOR 1254; PENTACHLOROPHENOL; POLYCHLORINATED BIPHENYL;

ACCESSORY SEX ORGAN; ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ASEPSIS; BIOCHEMISTRY; BLOOD CHEMISTRY; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ESTRUS; FEMALE; HEART; HISTOLOGY; HISTOPATHOLOGY; KIDNEY; NONHUMAN; ORGAN WEIGHT; OVARY; OVARY FUNCTION; PAPANICOLAOU TEST; RAT; REPRODUCTIVE TOXICITY; SPLEEN; STAINING; SURGICAL TECHNIQUE; TISSUE SECTION; TOXICITY TESTING; UTERINE CERVIX; UTERINE TUBE; UTERUS;

ADRENAL GLANDS; ANIMALS; CALCIUM PHOSPHATES; CERAMICS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; FEMALE; GENITALIA, FEMALE; HEART; INJECTIONS, INTRAMUSCULAR; KIDNEY; LYSINE; ORGAN SIZE; PHOSPHATES; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN;

EID: 0034066431     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

1. Agency for Toxic Substances and Disease Registry, Toxicological profile for selected PCBs (Aroclor-1260, -1254, -1248, -1242, -1232, -1221, and -1016) 1989.
2. Rammamoorthy K, Vyhidal C, Wang F, Chen IC, Safe S, McDonald DP, Leonard LS, Gaido KW. Additive estrogenic activities of a binary mixture of 2',4,6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicology and Applied Pharmacology 1997; 147:93-100.
3. Hutzinger O. The chemistry of PCBs. Cleveland: CRC Press, c1974.
4. Arcaro KF, Liangdong Y, Seegal RF, Vakharia DD, Yang Y, Spink DC, Broch K, Gierthy JF. 2,2',6,6'-Tetrachlorobiphenyl is estrogenic in vitro and in vivo. Journal of Cellular Biochemistry 1999; 72:94-102.
5. Connor K, Ramamoorthy, K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. Reproductive Toxicology 1997; 10(6):111-23.
6. Fielden, MR, Chen I, Chittim B, Safe S, Zacharewski TR. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenyol (HO-PCB 104), and a further chlorinated derivative 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives 1997; 105:1238-48.20.
7. Lind PM, Eriksen EF, Sahlin L, Edlund M, Orberg J. Effects of the antiestrogenic environmental pollutant 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. Toxicology and Applied Pharmacology 1999;154:236-44.
8. Brezner E, Terkel J, Perry A. The effect of Aroclor 1254 (PCB) on the physiology of reproduction in the female rat. Comparative Biochemical Physiology 1984; 77:65-70.
9. Benghuzzi H, Bajpai P. Ceramic drug delivery systems for long term delivery of chemicals and biologicals. J. Biomed Mater Res 1988; 22: 1245-1266,.
10. Benghuzzi H, Babaro R, Bajpai P. Continued and sustained release of AZT in vitro from TCP drug delivery systems. Biomedical Sciences Instrumentation 1990; 25: 169-177.
11. Benghuzzi H, England B, Bajpai P. Sustained release of norepinephrine by means of ceramic drug delivery devices. Tenth Southern Biomedical Engineering Conference 1991; Oct 18-21: 122-124, 1991.
12. Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SS. 3,3,4,4'- tetrachlorobiphenyl exhibits antiestrogenic and antiumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis 1999; 20(1): 115-23.