Pharmacokinetics of inhaled anaesthetics in a clinical setting: Description of a novel method based on routine monitoring data

British Journal of Anaesthesia

Volumn 84, Issue 4, 2000, Pages 437-442

  Rietbrock, S ^a   Wissing, H ^b   Kuhn, I ^b   Fuhr, U ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Anaesthetics volatile, desflurane; Anaesthetics volatile, isoflurane; Anaesthetics volatile, sevoflurane; Pharmacokinetics, models

Indexed keywords

DESFLURANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; SEVOFLURANE;

ARTICLE; CLINICAL ARTICLE; COMPARTMENT MODEL; DRUG CLEARANCE; DRUG DISTRIBUTION; ERROR; GENERAL ANESTHESIA; HUMAN; LUNG VENTILATION; PATIENT MONITORING; PRIORITY JOURNAL; TECHNIQUE;

EID: 0034066406     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.bja.a013466     Document Type: Article

References (15)

1. Carpenter RL, Eger EI 2nd, Johnson BH, Unadkat JD, Sheiner LB. Pharmacokinetics of inhaled anesthetics in humans. Anesth Analg 1986; 65: 575-82
2. Yasuda N, Lockhart SH, Eger EI 2nd, Weiskopf RB, Johnson BH, Freire BA, Fassoulaki A. Kinetics of desflurane, isoflurane and halothane in humans. Anesthesiology 1991; 74: 489-98
3. Yasuda N, Lockhart SH, Eger EI 2nd, Weiskopf RB, Lui J, Laster M, Taheri S, Peterson NA. Comparison of kinetics of sevoflurane and isoflurane in humans. Anesth Analg 1991; 72: 489-98
4. Wissing H, Kuhn I, Rietbrock S, Fuhr U. Pharmacokinetics of inhaled anaesthetics in a clinical setting: comparison of desflurane, isoflurane and sevoflurane. Br J Anaesth 2000; 84: 443-9
5. Schwilden H, Tonner PH, Röpcke H. Voraussagbarkeit in- und endexspiratorischer Isofluran- und Enflurankonzentrationen durch pharmakokinetische Modelle und interindividuelle Variabilität. Anästhes Intensivther Notfallmed 1990; 25, 317-21
6. Lerou JGC, Dirksen R, Beneken Kolmer HH, Booij LHDJ. A system model for closed-circuit inhalation anesthesia. I. Computer study. Anesthesiology 1991; 75: 345-55
7. Lerou JGC, Dirksen R, Beneken Kolmer HH, Booij LHDJ, Borm GF. A system model for closed-circuit inhalation anesthesia. II. Clinical validation. Anesthesiology 1991; 75: 230-7
8. Eger EI 2nd, Guadagni NP. Halothane uptake in man at constant alveolar concentration. Anesthesiology 1963; 24: 299-304
9. Wissing H, Kuhn l. Beeinflussung der inspiratorischen Atemgasmessung durch die Kreisteilkonstruktion und die Beatmungsschläuche. Anästhesiol Intensivmed Notfallmed Schmerzther 1997; 32: S185 [abstract]
10. Press WH, Teukolsky SA, Vetterling WT, Flannery BP. Numerical recipes in C. Cambridge: Cambridge University Press, 1992
11. Lin CY. Uptake of anaesthetic gases and vapours. Anaesth Intensive Care 1994; 22: 363-73
12. Epstein RM, Rackow H, Salanitre E, Wolf GL. Influence of the concentration effect on the uptake of anesthetic mixtures: the second gas effect. Anesthesiology 1964; 25: 364-71
13. Korman B, Mapleson WW. Concentration and second gas effect: can the accepted explanation be improved? Br J Anaesth 1997; 78: 618-25
14. Severinghaus JW. The rate of nitrous oxide uptake in man. J Clinical Invest 1954; 33: 1183-9
15. Seber GAF, Wild CJ. Nonlinear Regression. New York: Wiley, 1989; 32