Distribution of protein turnover changes with age in humans as assessed by whole-body magnetic resonance image analysis to quantify tissue volumes

Journal of Nutrition

Volumn 130, Issue 4, 2000, Pages 784-791

  Morais, José A ^a,b,c   Ross, Robert ^a   Gougeon, Réjeanne ^d   Pencharz, Paul B ^e   Jones, Peter J H ^a   Marliss, Errol B ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c QUEEN S UNIVERSITY   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

Aging; Elderly humans; Magnetic resonance imaging; N' methylhistidine; Protein turnover

Indexed keywords

ADIPOSE TISSUE; ADULT; AGE; AGED; ARTICLE; FEMALE; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; MALE; MUSCLE MASS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN DEGRADATION; PROTEIN METABOLISM;

EID: 0034065780     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.4.784     Document Type: Article

References (54)

1. T-methylhistidine and creatine in human urine. Biochem. J. 200: 449-452.
2. Boirie, Y., Gachon, P. & Beaufrère, B. (1997) Splanchnic and whole-body leucine kinetics in young and elderly men. Am. J. Clin. Nutr. 65: 489-495.
3. Campbell, W. W., Crim, M. C., Dallal, G. E., Young V. R. & Evans W. J. (1994) Increased protein requirements in elderly people: new data and retrospective reassessments. Am. J. Clin. Nutr. 60: 501-509.
4. Cohn, S. H., Vartsky, D., Yasumura, S,. Sawitsky, A., Zanzi, I., Vaswani, A. & Ellis, K. J. (1980) Compartmental body composition based on total-body nitrogen, potassium and calcium. Am. J. Physiol. 239 (Endocrinol:Metab.2): E524-E530.
5. de Weir, J. B. (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J. Physiol. 109: 1-9.
6. Després, J.-P., Nadeau, A., Tremblay, A., Ferland, M., Moorjani, S., Lupien, P. J., Thériault, G., Pinault, S. & Bouchard, C. (1989) Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 38: 304-309.
7. Durnin, J. V. G. & Womersley, J. (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J. Nutr. 32: 77-97.
8. Flynn, M. A., Nolph, G. B., Sherwood Baker, A., Martin, W. A. & Krause, G. (1989). Total body potassium in aging humans: a longitudinal study. Am. J. Clin. Nutr. 50: 713-717.
9. Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J. Psych. Res. 12: 189-198.
10. Forbes, G. B. & Reina, J. C. (1970) Adult lean body mass declines with age: some longitudinal observations. Metabolism 19: 653-663.
11. Fukagawa, N. K., Minaker, K. L., Young, V. R., Matthews, D. E., Bier, D. M. & Rowe, J. W. (1989) Leucine metabolism in aging humans: effect of insulin and substrate availability. Am. J. Physiol. 256 (Endocrinol:Metab.19): E288-E294.
12. Garrel, D. R., Razi, M., Larivière, F., Jobin, N., Naman, N., Emptoz-Bonneton, A. & Pugeat, M. M. (1995) Improved clinical status and length of care with low-fat nutrition support in burn patients. J. Parent. Ent. Nutr. 19: 482-491.
13. 14C]leucine kinetics in splanchnic and leg tissues in humans. Diabetes 37: 1365-1372.
14. Gersovitz, M., Munro, H. N., Udall, J. & Young, V. R. (1980) Albumin synthesis in young and elderly subjects using a new stable isotope methodology: response to level of protein intake. Metabolism 29: 1075-1086.
15. 14C] leucine. Clin. Sc. Molecul. Med. 53: 277-288.
16. Goldspink, D. F. & Kelly, F. J. (1984) Protein turnover and growth in the whole-body, liver and kidney of the rat from the fetus to senility. Biochem. J. 217: 507-516.
17. Gougeon, R., Pencharz, P. B. & Marliss, E. B. (1994) Effect of NIDDM on the kinetics of whole- body protein metabolism. Diabetes 43: 318-328.
18. Gougeon, R., Pencharz, P. B. & Sigal, R. J. (1997) Effect of glycemic control on the kinetics of whole-body protein metabolism in obese subjects with non-insulin-dependent diabetes mellitus during iso- and hypoenergetic feeding. Am. J. Clin. Nutr. 65: 861-879.
19. Hall, J. C. (1983) A method for the rapid assessment of sample size in dietary studies. Am. J. Clin. Nutr. 37: 473-477.
20. T-methylhistidine in urine. Biochem. J. 194: 1011-1014.
21. 63 Ni as tracer. Anal. Biochem. 36: 105-113.
22. Ivy, J. L., Young, J. C., Craig, B. W., Kohrt, W. M. & Holloszy, J. O. (1991) Aging, exercise and food restriction: effects on skeletal muscle glucose uptake. Mech. Aging Dev. 61: 123-133.
23. Jackson, R. A. (1989) Mechanisms of age-related glucose intolerance. Diabetes Care 13(suppl. 2): 9-19.
24. Kohrt, W. M., Malley, M. T., Dalsky, G. P. & Holloszy, J. O. (1992) Body composition of healthy sedentary and trained, young and older men and women. Med. Sci. Sports Exerc. 24: 832-837.
25. Marliss, E. B., Murray, F. T. & Nakhooda, A. F. (1978) The metabolic response to hypocaloric protein diets in obese man. J. Clin. Invest. 62: 468-479.
26. Mays, P. K., McAnulty, R. J. & Laurent, G. J. (1991) Age-related changes in rates of protein synthesis and degradation in rat tissue. Mech. Aging Dev. 59: 229-241.
27. McGandy, R. B., Barrows, C. H., Spanias, A., Meredith, A., Stone, J. L. & Norris, A. H. (1966) Nutrient intakes and energy expenditure in men of different ages. J. Gerontol. 21: 581-587.
28. Meneilly, G. S., Ryan, A. S., Veldhuis, J. D. & Elahi, D. (1997) Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J. Clin. Endocrinol. Metab. 82: 4088-4093.
29. Millward, D. J., Fereday, A., Gibson, N. & Pacy P. J. (1997) Aging, protein requirements, and protein turnover. Am. J. Clin. Nutr. 66: 774-786.
30. Mitsiopoulos N., Baumgartner, R. N. Heymsfield, S. B., Lyons, W., Gallagher, D. & Ross, R. (1998) Cadaver validation of magnetic resonance imaging and computerized tomography measurement of human skeletal muscle. J. Appl. Physiol. 85: 115-122.
31. Morais, J. A., Gougeon, R., Pencharz, P. B., Jones, P. J. H., Ross, R. & Marliss, E. B. (1997) Whole-body protein turnover in the elderly. Am. J. Clin. Nutr. 66: 880-889.
32. Morais, J. A., Ross, R., Gougeon, R., Pencharz, P. B., Jones, P. J. H. & Marliss, E. B. (1997) Aging and protein turnover: altered contributions of muscle vs nonmuscle tissues assessed by whole-body MRI. Am. J. Clin. Nutr. 66: 210. (abstr).
33. Mosoni, L., Patureau-Mirand, P., Houlier, M. L. & Arnal, M. (1993) Age-related changes in protein synthesis measured in vivo in rat liver and gastrocnemius. Mech. Aging Dev. 68: 209-220.
34. Picou, D. & Taylor-Roberts, T. (1969) The measurement of total protein synthesis and catabolism and nitrogen turnover in infants in different nutritional states receiving different amounts of dietary protein. Clin. Sci. 36: 283-296.
35. 13C]leucine, in healthy young and elderly adults. J. Gerontol. 39: 673-681.
36. Roberts, S. B., Fuss, P., Heyman, M. B. & Young, V. R. (1995) Influence of age on energy requirements. Am. J. Clin. Nutr. 62(suppl):1053S-1058S.
37. Rosenthal, M., Haskel, W. L., Solomon, R., Widstrom, A. & Reaven, G. M. (1983) Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes 32: 408-411.
38. Ross, R., Léger, L., Morris, D. V., de Guise, J. & Guardo, R. (1992) Quantification of adipose tissue by MRI: relationship with anthropometric variables. J. Appl. Physiol. 72: 787-795.
39. Ross, R., Rissanen, J., Pedwell, H., Clifford, J. & Shragge, P. (1996) Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J. Appl. Physiol. 81: 2445-2455.
40. Rowe, J. W. & Kahn, R. L. (1987) Human aging: usual and successful. Science 237: 143-149.
41. Rudman, D. (1985) hormone, body composition and aging. J. Am. Geriatr. Soc. 33: 800-807.
42. Steffee, W. P., Goldstein, R. S., Pencharz, P. B., Schrimshaw, N. S. & Young, V. R. (1976) Dietary protein intake and dynamic aspects of whole body nitrogen metabolism in adult humans. Metabolism 25: 281-297.
43. Uauy, R., Winterer, J. C., Bilmazes, C., Haverberg, L. N., Scrimshaw, N. S., Munro, H. N. & Young, V. R. (1978) The changing pattern of whole body protein metabolism in aging humans. J. Gerontol. 33: 663-671.
44. Visser, M., Deurenberg, P., van Staveren, W. A. & Hautvast, J. G. A. J. (1995) Resting metabolic rate and diet-induced thermogenesis in young and elderly subjects: relationship with body composition, fat distribution, and physical activity level. Am. J. Clin. Nutr. 61: 772-778.
45. T-Methylhistidine - an index of the true rate of myofibrillar degradation? An appraisal. Life Sci. 23: 1103-1115.
46. Ward, M. W. N., Owens, C. W. I. & Rennie, M. S. (1980) Nitrogen estimation in biological samples by use of chemiluminescence. Clin. Chem. 26: 1336-1339.
47. Ward, W. & Richardson, A. (1991) Effects of age on liver protein synthesis and degradation. Hepatology 14: 935-948.
48. 15 N: comparision of end products and dose regimens. Am. J. Physiol. 235 (Endocrinol:Metab.2): E165-E174.
49. Welle, S., Thornton, C., Jozefowicz, R. & Statt, M. (1993) Myofibrillar protein synthesis in young and old men. Am. J. Physiol. 264 (Endocrinol:Metab.27): E693-E698.
50. Welle, S., Thornton, C. & Statt, M. (1995) Myofibrillar protein synthesis in young and old human subjects after three months of resistant training. Am. J. Physiol. 268 (Endocrinol:Metab.31): E422-E427.
51. Yarasheski, K. E., Zachwieja, J. J. & Bier, D. M. (1993) Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am. J Physiol. 265 (Endocrinol:Metab.28): E210-E214.
52. Young, V. R. (1990) Amino acids and proteins in relation to the nutrition of elderly people. Age Aging 19: 510-524.
53. T-Methylhistidine (3-methylhistidine) and muscle protein turnover: an overview. Federation Proc. 37: 2291-2300.
54. Young, V. R., Steffee, W. P., Pencharz, P. B., Winterer, J. C., & Schrimshaw, N. S. (1975) Protein turnover in the whole body. Nature 253: 192-194.