Naivety in the molecular life sciences

Futures

Volumn 32, Issue 5, 2000, Pages 451-470

  Strand, Roger ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GENE TECHNOLOGY; IN VITRO STUDY; MOLECULAR LIFE SCIENCE; RISK ASSESSMENT;

ACADEMIC RESEARCH;

EID: 0034065305     PISSN: 00163287     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-3287(99)00086-5     Document Type: Article

References (83)

1. Funtowicz S, Ravetz JR. The good, the true and the post-modern. Futures 1992;24:963-76.
2. Funtowicz S, Ravetz JR. Science for the post-normal age. Futures 1993;25:739-55.
3. Funtowicz S, Ravetz JR. Emergent complex systems. Futures 1994;26:566-82.
4. Funtowicz S, Ravetz JR. The poetry of thermodynamics. Futures 1997;29:791-810.
5. Sram RJ. Future research directions to characterize environmental mutagens in highly polluted areas. Envir Health Perspect 1996;104:603-7.
6. Osbild D, Babut M, Vasseur P. Review-state of the art: biosensors for environmental monitoring and water control. Rev Sei l'Eau 1995;8:505-38.
7. Barrett JC, Vainio H, Peakall D, Goldstein BD. 12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: susceptibility to environmental hazards (Espoo, Finland, March 17-22, 1996). Envir Health Perspect 1997; 105:699-737.
8. van Leeuwen CJ, Bro Rasmussen F, Feijtel TCJ, Arndt R, Bussian BM, Calamari DL, Glynn P, Grandy NJ, Hansen B, Van Hemmen JJ, Hurst P, King N, Koch R, Muller M, Solbe JF, Speijers GAB, Vermeire T. Risk assessment and management of new and existing chemicals. Envir Toxic Pharmac 1996;2:243-99.
9. Elespuru RK. Future approaches to genetic toxicology risk assessment. Mutat Res 1996;365:191-204.
10. Schneegurt MA, Kulpa CF Jr. The application of molecular techniques in environmental biotechnology for monitoring microbial systems. Biotechnol Appl Biochem 1998;27:73-9.
11. Funtowicz S, Ravetz JR. Uncertainty and quality in science for policy. Dordrecht: Kluwer, 1990.
12. Wynne B. Uncertainty and environmental learning-reconceiving science and policy in the preventive paradigm. Glob Envir Change 1992;2:111-27.
13. Funtowicz S, Ravetz JR. Uncertainty and regulation. In: Campagnari F, Sgaramella V, van den Eede G, editors. Scientific-technical backgrounds for biotechnology regulations. Dordrecht: Kluwer, 1994:133-42.
14. Crick F. The astonishing hypothesis: the scientific search for the soul. New York: Scribner, 1994.
15. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular biology of the cell. New York: Garland Publishing, 1983.
16. Wilson EO. Consilience: the unity of knowledge. New York: Knopf, 1998.
17. Kay LE. The molecular vision of life. Caltech, the Rockefeller Foundation, and the rise of new biology. New York: Oxford University Press, 1993.
18. Barondes SH. Molecules and mental illness. New York: Scientific American Library, 1993.
19. Jacob F. The state within: an autobiography. New York: Basic Books, 1988.
20. Monod J. Chance and necessity: an essay on the natural philosophy of modern biology. New York: Knopf, 1971.
21. Trevan MD, Boffey S, Goulding KH, Stanbury P. Biotechnology: the biological principles. Milton Keynes: Open University Press, 1987.
22. Koshland DE. In pursuit of the renewable frontier. In: Koshland DE, editor. Biotechnology: the renewable frontier. Washington: American Association for the Advancement of Science, 1986:ix-x.
23. Eigen M. What will endure of 20th century biology? In: Murphy MP, O'Neill LAJ, editors. What is life? The next fifty years. Speculation on the future of biology. Cambridge: Cambridge University Press, 1995:5-23.
24. Beckwith J. The hegemony of the gene: reductionism in molecular biology. In: Sarkar S, editor. The philosophy and history of molecular biology: new perspectives. Dordrecht: Kluwer, 1996:171-83.
25. Kitcher P. 1953 and all that: a tale of two sciences. In: Boyd R, Gasper P, Trout JD, editors. The philosophy of science. Cambridge, MA: MIT Press, 1991:553-70.
26. Sarkar S. Biological information: a skeptical look at some central dogmas of molecular biology. In: Sarkar S, editor. The philosophy and history of molecular biology: new perspectives. Dordrecht: Kluwer, 1996:187-231.
27. Garfinkel A. Reductionism. In: Boyd R, Gasper P, Trout JD, editors. The philosophy of science. Cambridge, MA: MIT Press, 1991:443-59.
28. Gad S. Alternatives to in vivo studies in toxicology. In: Ballantyne B, Marrs T, Turner P, editors. General and applied toxicology. New York: Stockton Press, 1993:179-206.
29. Scala RA. Theoretical approaches to validation. In: Goldberg AM, editor. In vitro toxicology. New York: Mary Ann Liebert, 1987:1-9.
30. National Research Council. Models for biomédical research. A new perspective. Washington DC: National Academy Press, 1985.
31. Strand R. Theoretical methodology in biochemistry. Dissertation. Bergen: Megaloceros Press, 1998.
32. Hüttenrauch R, Speiser P. In vitro-in vivo correlation: an unrealistic problem. Pharmaceut Res 1985;3:97-107.
33. Collinge J, Palmer MS, Sidle KC, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL. Unaltered susceptibility to BSE in transgenic mice expressing human prion protein. Nature 1995;378:779-83.
34. Anon. Statement by the UK Spongiform Encephalopathy Advisory Committee, 1997.
35. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alperovitch A, Poser S, Pocchiari M, Hofman A, Smith PG. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996;347:921-5.
36. Ridley RM, Baker HE. Oral transmission of BSE to primates [letter]. Lancet 1996;348:1174.
37. Cousens SN, Vynnycky E, Zeidler M, Will RG, Smith PG. Predicting the CJD epidemic in humans. Nature 1997;385:197-8.
38. Raymond GJ, Hope J, Kocisko DA, Priola SA, Raymond LD, Bossers A, Ironside J, Will RG, Chen SO, Petersen RB, Gambetti P, Rubenstein R, Smits MA, Lansbury PT Jr, Caughey B. Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature 1997;388:285-8.
39. Strand R, Fjelland R, Flatmark T. In vivo interpretation of in vitro effect studies with a detailed analysis of the method of in vitro transcription in isolated cell nuclei. Acta Biotheor 1996;44:1-21.
40. Schardein JL. Drugs as teratogens. Cleveland: CRC Press, 1976.
41. Teff H, Munro CR. Thalidomide: the legal aftermath. Farnborough, UK: Saxon House, 1976.
42. Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. New Eng J Med 1971;284:878-81.
43. Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol revisited: a review of the long-term health effects. Ann Intern Med 1995;122:778-88.
44. Nielsen KM, Bones AM, Smalla K, van Elsas JD. Horizontal gene transfer from transgenic plants to terrestrial bacteria - a rare event? FEMS Microbiol Rev 1998;22:79-103.
45. Krishnapillai V. Horizontal gene transfer. J Genet 1996;75:219-32.
46. Powell DA, Leiss W, Griffiths A, Barren K. Gene escape, or the pall of silence over plant biotechnology risk. In: Powell D, Leiss W, editors. Mad cows and mother's milk: the perils of poor risk communication. Montreal: McGill-Queen's University Press, 1997:153-81.
47. Spencer LJ, Snow AA, Nameth ST. Fitness of transgenic wild-crop hybrids of Cucurbita pepo: a field test with wild plants. Am J Bot 1997;84:91.
48. van Raamsdonk LWD, Scheuten HJ. Gene flow and establishment of transgenes in natural plant populations. Acta Bot Neerland 1997;46:69-84.
49. Mikkelsen TR, Andersen B, Jørgensen RB. The risk of crop transgene spread. Nature 1996;380:31.
50. Mikkelsen TR, Jensen J, Jørgensen RB. Inheritance of oilseed rape (Brassica napus) RAPD markers in a backcross progeny with Brassica campestris. Theoret Appl Genet 1996;92:492-7.
51. Linder CR, Taha I, Seiler GJ, Snow AA, Rieseberg LH. Long-term introgression of crop genes into wild sunflower populations. Theoret Appl Genet 1998;96:339-47.
52. Darmency H, Lefol E, Fleury A. Spontaneous hybridizations between oilseed rape and wild radish. Molec Ecol 1998;7:1467-73.
53. Klinger T, Elam DR, Ellstrand NC. Radish as a model system for the study of engineered gene escape rates via crop-weed mating. In: Ehrenfeld D, editor. Readings from conservation biology: genes, populations, and species. Cambridge, MA: Blackwell, 1995:239-43.
54. Rissler J, Mellon M. The ecological risks of engineered crops. Cambridge, MA: MIT Press, 1996.
55. Kaul MLH, Nirmala C. Biotechnology: miracle of mirage transgenic plants: progress and potence. J Phytol Res 1995;8:l-26.
56. Ellstrand NC, Prentice HC. Will transgenes escape into natural populations? Am J Bot 1995;82(6 Suppl.):68.
57. Hatch EE, Palmer JR, Titus Ernstoff L, Möller KL, Kaufman RH, Mittendorf R, Robboy SJ, Hyer M, Cowan CM, Adam E, Colton T, Hartge P, Hoover RN. Cancer risk in women exposed to diethylstilbestrol in utero. JAMA 1998;280:630.
58. van Gaal Tami M, Galatowitsch SM, Strefeler MS. Ecological consequences of hybridization between a wild species (Echinacea purpurea) and related cultivar (E. purpurea 'White Swan'). Sei Horticult 1998;76:73-88.
59. Stewart CN, All JN, Raymer PL, Ramachandran S. Increased fitness of transgenic insecticidal rapeseed under insect selection pressure. Molec Ecol 1997;6:773-9.
60. Griffiths A, Barrett K. Addendum to ch. 7: gene escape, or the pall of silence over plant biotechnol-ogy risk. In: Powell D, Leiss W, editors. Mad cows and mother's milk: the perils of poor risk communication. Montreal: McGill-Queen's University Press, 1997:179-81.
61. Funtowicz S, O'Connor M. The passage from entropy to thermodynamic indeterminacy: a social and science epistemology for sustainability. In Mayumi K, Gowdy J, editors. Bioeconomics and sustainability: essays in honour of Nicholas Georgescu-Roegen, 1999 (in press).
62. Kitcher P. The advancement of science: science without legend, objectivity without illusions. New York: Oxford University Press, 1993.
63. Bloor D. Knowledge and social imagery. London: Routledge & Kegan Paul, 1976.
64. Pickering A. Science as practice and culture. Chicago: University of Chicago Press, 1992.
65. Latour B, Woolgar S. Laboratory life: the social construction of scientific facts. Beverly Hills: Sage Publications, 1979.
66. Knorr Cetina K. The couch, the cathedral, and the laboratory: on the relationship between experiment and laboratory in science. In: Pickering A, editor. Science as practice and culture. Chicago: University of Chicago Press, 1992:113-38.
67. Hacking I. Representing and intervening: introductory topics in the philosophy of natural science. Cambridge: Cambridge University Press, 1983.
68. Hacking I. The participant irrealist at large in the laboratory. Br J Phil Sei 1988;39:277-94.
69. Pickering A. The mangle of practice: time, agency and science. Chicago: University of Chicago Press, 1995.
70. Kühn TS. The structure of scientific revolutions. Chicago: University of Chicago Press, 1970.
71. Kühn TS. The road since structure. PSA 1990;2:3-13.
72. Latour B. Science in action: how to follow scientists and engineers through society. Milton Keynes: Open University Press, 1987.
73. Latour B. The pasteurization of France. Cambridge, MA: Harvard University Press, 1988.
74. Fujimura JH. Grafting science: a sociohistory of the quest for the genetics of cancer. Cambridge, MA: Harvard University Press, 1996.
75. Strand R. Towards a useful philosophy of biochemistry: sketches and examples. Foundations of chemistry 1999;1:271-94.
76. Rheinberger HJ. Toward a history of epistemic things: synthesizing proteins in the test tube. Stanford: Stanford University Press, 1997.
77. Ginzburg LR. Assessing ecological risks of biotechnology. Boston: Butterworth-Heinemann, 1991.
78. van der Steen W. Toward a practicable methodology for medicine: the impact of conceptual analysis. Perspect Biol Med, 1993;36:580-91.
79. van der Steen W. Concepts in biology: a survey of practical methodological principles. J Theoret Biol 1990;143:383-403.
80. van der Steen W. Facts, values, and methodology. A new approach to ethics. Amsterdam: Rodopi, 1995.
81. Lindgaard Pedersen J. Public debate on biotechnology: the case of Denmark. In: Yoxen E, Di Martino V, editors. Biotechnology in future society. Scenarios and options for Europe. Aldershot: Dart-mouth Publishing Co, 1989:107-16.
82. Fixdal J. Consensus conferences as extended peer groups. Sei Public Pol 1997;24:366-76.
83. www.etikkom.no