Augmentation of SR Ca2+ release by rapamycin and FK506 causes K+-channel activation and membrane hyperpolarization in bladder smooth muscle

British Journal of Pharmacology

Volumn 129, Issue 7, 2000, Pages 1293-1300

  Weidelt, Th ^a   Isenberg, G ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b NONE

Author keywords

FKBP; Relaxation; Smooth muscle cells; STOCs

Indexed keywords

CALCIUM ION; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL; POTASSIUM ION; RAPAMYCIN; TACROLIMUS;

ANIMAL CELL; ARTICLE; BLADDER MUSCLE; CALCIUM TRANSPORT; GUINEA PIG; HYPERPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE FIBER MEMBRANE; VOLTAGE CLAMP;

EID: 0034065210     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703223     Document Type: Article

References (29)

1. Ahern, G.P., Junakar, P.R. & Dulhunty, A.F. (1997). Ryanodine receptors from rabbit skeletal muscle are reversibly activated by rapamycin. Neurosci. Lett., 225, 81-84.
2. Benham, C.D., Bolton, T.B. & Lang, R.J. (1985). Acetylcholine activates an inward current in single mammalian smooth muscle cells. Nature, 316, 345-347.
3. Benham, C.D., Bolton, T.B., Lang, R.J. & Takewaki, T. (1986). Calcium-activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea-pig mesenteric artery. J. Physiol., 371, 45-67.
4. Bielefeldt, K., Sharma, R.V., Whiteis, C., Yedidag, E. & Abboud, F.M. (1997). Tacrolimus (FK506) modulates calcium release and contractility of intestinal smooth muscle. Cell Calcium, 22, 507-514.
5. Bolton, T.B. & Imaizumi, Y. (1996). Spontaneous transient outward currents in smooth muscle cells. Cell Calcium, 20, 141-152.
6. Brayden, J.E. & Nelson, M.T. (1992). Regulation of arterial tone by activation of calcium-dependent potassium channels. Science, 256, 532-535.
7. 2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. Proc. Nat. Acad. Sci. U.S.A., 91, 11953-11957.
8. Drake, M., Friberg, H., Boris-Möller, F., Sakata, K. & Wieloch, T. (1996). The immunosuppressant FK506 ameliorates ischemic damage in rat brain. Acta Physiol. Scand., 158, 155-159.
9. Ganitkevich, V. & Isenberg, G. (1990). Isolated guinea pig coronary smooth muscle cells: Acetylcholine induces hyperpolarization due to sarcoplasmic reticulum calcium release activating potassium channels. Circ. Res., 67, 525-528.
10. Ganitkevich, V. & Isenberg, G. (1991). Depolarization-mediated intracellular calcium transients in isolated smooth muscle cells of guinea-pig urinary bladder. J. Physiol., 435, 187-205.
11. 2+ transients in guinea pig coronary myocytes. J. Physiol., 470, 35-44.
12. 2+] in myocytes from guinea-pig coronary artery. J. Physiol., 490, 305-318.
13. Gordienko, D.V., Bolton, T.B. & Cannell, M.B. (1998). Variability in spontaneous subcellular calcium release in guinea-pig ileum smooth muscle cells. J. Physiol., 507, 707-720.
14. 2+ -release channels from cardiac muscle. Circ. Res., 78, 990-997.
15. Klöckner, U. & Isenberg, G. (1985). Action potential and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea-pig). Pflügers Arch., 405, 329-339.
16. Klöckner, U. & Isenberg, G. (1989). The dihydropyridine niguldipine modulates calcium and potassium currents in vascular smooth muscle cells. Br. J. Pharmacol., 97, 957-967.
17. c increase. J. Recept. Signal Transduct. Res., 17, 149-161.
18. Mayrleitner, M., Timerman, A.P., Wiederrecht, G. & Fleischer, S. (1994). The calcium release channel of sarcoplasmic reticulum is modulated by FK-506 binding protein: Effect of FKBP-12 on single channel activity of the skeletal muscle ryanodine receptor. Cell Calcium, 15, 99-108.
19. 2+ homeostasis in smooth muscle. Pharmac. Ther., 56, 191-231.
20. Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A.D., Knot, H.J. & Lederer, W.J. (1995). Relaxation of arterial smooth muscle by calcium sparks. Science, 270, 633-637.
21. Nelson, M.T. & Quayle, J.M. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol. (Cell Physiol.), 268, C799-C822.
22. 2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides. Am. J. Physiol. (Cell Physiol.), 274, C1346-C1355.
23. Stehno-Bittel, L. & Sturek, M. (1992). Spontaneous sarcoplasmic reticulum calcium release and extrusion from bovine, not porcine, coronary artery smooth muscle. J. Physiol., 451, 49-78.
24. 2+ -ions. Pflügers Arch., 414, S183-S184.
25. Wagenknecht, T., Grassucci, R., Berkowitz, J., Wiederrecht, G.J., Xin, H.B. & Fleischer, S. (1996). Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor. Biophys. J., 70, 1709-1715.
26. 2+ release apparatus in smooth muscle of the urinary bladder. Pflügers Arch., 435, P31.
27. 2+ release channel closure in rat heart. J. Physiol., 500, 343-354.
28. 2+ current by sarcoplasmic reticulum of guinea pig urinary bladder myocytes. Am. J. Physiol., 271, C833-C841.
29. Zarnt, T., Lang, K., Burtscher, H. & Fischer, G. (1995). Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond. Biochem. J., 305, 159-164.