Neonatal thrombocytopenia in two of six human platelet alloantigen (HPA) 5a-positive children of an HPA-5a-immunized mother

Transfusion Medicine

Volumn 10, Issue 1, 2000, Pages 81-85

  Kekomaki S ^a   Koskela, S ^a   Laes, M ^b   Teramo, K ^c   Kekomaki R ^a  

^a FINNISH RED CROSS BLOOD SERVICE   (Finland)

^b JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Neonatal thrombocytopenia; Platelet antibodies; Platelet antigens

Indexed keywords

5A ALLOANTIGEN, HUMAN; ALLOANTIGEN; EPITOPE; THROMBOCYTE ANTIGEN;

ADULT; ARTICLE; CASE REPORT; FEMALE; FETOMATERNAL TRANSFUSION; GENETIC POLYMORPHISM; GENETICS; HUMAN; IMMUNOLOGY; NEWBORN; PREGNANCY; THROMBOCYTOPENIA;

ADULT; ANTIGENS, HUMAN PLATELET; EPITOPES; FEMALE; HUMANS; INFANT, NEWBORN; ISOANTIGENS; MATERNAL-FETAL EXCHANGE; POLYMORPHISM, GENETIC; PREGNANCY; THROMBOCYTOPENIA;

EID: 0034063754     PISSN: 09587578     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3148.2000.00235.x     Document Type: Article

References (12)

1. b, a platelet alloantigen involved in neonatal alloimmune thrombocytopenia. Vox Sanguinis, 60, 230-234.
2. Hohlfeldt, P., Forestier, F., Kaplan, C., Tissot, J.D. & Daffos, F. (1994) Fetal thrombocytopenia: a retrospective survey of 5194 fetal blood samplings. Blood, 84, 1851-1856.
3. Joutsi, L. & Kekomäki, R. (1997) Comparison of the direct platelet immunofluorescence test (direct PIFT) with a modified direct monoclonal antibody-specific immobilization of platelet antigens (direct MAIPA) in detection of platelet-associated IgG. British Journal of Haematology, 96, 204-209.
4. Kanhai, H.H., Porcelijn, L., van Zoeren, D., Klumper, F., Vietor, H., Meerman, R.H. & Brand, A. (1996) Antenatal care in pregnancies at risk of alloimmune thrombocytopenia: report of 19 cases in 16 families. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 68, 67-73.
5. a) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases. British Journal of Haematology, 78, 425-429.
6. Kekomäki, S., Partanen, J. & Kekomäki, R. (1995) Platelet alloantigens HPA-1-2-3-5 and -6b in Finns. Transfusion Medicine, 5, 193-198.
7. Kiefel, V., Kroll, H., Bonnert, J., Unkelbach, K., Katzmann, B., Nebenführer, Z., Santoso, S. & Mueller-Eckhardt, C. (1993) Platelet alloantigen frequencies in Caucasians: a serological study. Transfusion Medicine, 3, 237-242.
8. b (HPA-5a). Report of three cases in two families. Vox Sanguinis, 60, 244-245.
9. 1 activity on platelets. Blood, 82, 2693-2703.
10. 2 gene coding sequence. Blood, 89, 1939-1943.
11. Reiner, A., Aramaki, K.M., Teramura, G. & Gaur, L. (1998) Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5) polymorphisms. Thrombosis and Haemostasis, 80, 449-456.
12. Santoso, S., Amrhein, J., Sachs, U., Mueller-Eckhardt, C. & Kiefel, V. (1997) Single point mutation in glycoprotein Ia is responsible for the formation of a new human platelet alloantigen (SIT) involved in neonatal alloimmune thrombocytopenia. Blood, 90 (Suppl. 1), 261a.