Induction and persistence of chromosome aberrations in human lymphocytes exposed to neutrons in vitro or in vivo: Implications of findings in 'retrospective' biological dosimetry

Radiation Protection Dosimetry

Volumn 88, Issue 1, 2000, Pages 59-68

  Littlefield, L G ^a   McFee, A F ^a   Sayer, A M ^a   O'Neill, J P ^b   Kleinerman, R A ^c   Maor, M H ^d  

^a OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEAM THERAPY; CELL CYCLE; CELL DIVISION; CHROMOSOME ABERRATION; CHROMOSOME PAINTING; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; DOSIMETRY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE; NEUTRON; PERIPHERAL CIRCULATION; RADIATION EXPOSURE;

EID: 0034063433     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.rpd.a033021     Document Type: Conference Paper

References (24)

1. Buckton, K. E., Jacobs, P. A., Court-Brown, W. M. and Doll, R. A. A Study of the Chromosome Damage Persisting after X-ray Therapy for Ankylosing Spondylitis. The Lancet 676-682 (1962).
2. Awa, A. A. Review of Thirty Years Study of Hiroshima and Nagasaki Atomic Bomb Survivors. II Biological Effects. G. Chromosome Aberrations in Somatic Cells. J. Radiat. Res. Suppl. 16, 122-131 (1975).
3. Littlefield, L. G. and Joiner, E. E. Cytogenetic Follow-up Studies in Six Radiation Accident Victims (16 and 17 years Post-exposure). In: Late Biological Effects of Ionizing Radiation. (Vienna: International Atomic Energy Agency) Vol. 1, pp. 297-308 (1978).
4. Kleinerman, R. A., Littlefield, L. G., Tarone, R. E., Machado, S. G., Blettner, M., Peters, L. J. and Boice Jr, J. D. Chromosome Aberrations in Peripheral Lymphocytes find Radiation Dose to Active Bone Marrow in Patients Treated for Cancer of the Cervix. Radiat. Res. 6, 176-190 (1989).
5. Lucas, J. N., and 10 others. Rapid Translocation Frequency Analysis in Humans Decades after Exposure to Ionizing Radiation. Int. J. Radiat. Biol. 62, 53-63 (1992).
6. Salassidis, K., Georgiadou-Schumacher, V., Brazelmann, H., Muller, P., Peter, R. U. and Bauchinger, M. Chromosome Painting in Highly Irradiated Chernobyl Victims: a Follow-up Study to Evaluate the Stability of Symmetrical Translocations and the Influence of Clonal Aberrations for Retrospective Dose Estimation. Int. J. Radiat. Biol. 68, 257-262 (1995).
7. Stephan, G. and Pressl, S. Chromosome Aberrations in Human Lymphocytes Analyzed by Fluorescence in situ Hybridization after in vitro Irradiation, and in Radiation Workers, 11 years after an Accidental Radiation Exposure. Int. J. Radiat. Biol. 71, 293-299 (1997).
8. Tucker, J. D., Tawn, E. J., Holdsworth, D., Morris, S., Langlois, R., Ramsey, M. J., Kato, P., Boice, Jr., J. D., Tarone, R. E. and Jensen, R. H. Biological Dosimetry of Radiation Workers at the Sellafield Nuclear Facility. Radiat. Res. 148, 216-226 (1997).
9. Lindholm, C., Salomaa, S., Tekkel, M., Paile, W., Koivistoinen, A., Ilus, T. and Veidebaum, T. Biodosimetry after Accidental Radiation Exposure by Conventional Chromosome Analysis and FISH. Int. J. Radiat. Biol. 70, 647-656 (1996).
10. Lucas, J. M., Poggensee, M. and Straume, T. The Persistence of Chromosome Translocations in a Radiation Worker Accidentally Exposed to Tritium. Cytogenet. Cell Genet. 60, 255-256 (1992).
11. Littlefield, L. G. and 13 others. Do Recorded Doses Overestimate True Doses Received by Chernobyl Cleanup Workers? Results of Estonian FISH studies. Radiat. Res. 150, 237-249 (1998).
12. Littlefield, L. G., Travis, L. B., Sayer, A. M., Voelz, G. L., Jensen, R. H. and Boice, Jr. J. D. Cumulative Genetic Damage in Hematopoietic Stem Cells in a Patient with a 40-year Exposure to Alpha Particles Emitted by Thorium Dioxide. Radiat. Res. 148, 135-144 (1997).
13. Boie, J. J. W. A., Vermeulen, S. and Natarajan, A. T. Detection of Chromosomal Aberrations by Fluorescence in situ Hybridization in the First Three Post-irradiation Divisions of Lymphocytes. Mutat. Res. 349, 127-135 (1996).
14. Matsumota, K., Ramsey, M. J., Nelson, D. O. and Tucker, J. D. Persistence of Radiation Induced Translocations in Human Peripheral Blood Determined by Chromosome Painting. Radiat. Res. 149, 602-613 (1998).
15. Hoffmann, G. R., Sayer, A. M., Joiner, E. E., McFee, A. F. and Littlefield, L. G. Analysis by FISH of the Spectrum of Chromosome Aberrations Induced by X-rays in G0 Lymphocytes and their Fate Through Mitotic Divisions in Culture. Environ. Mol. Mutagen. 33, 94-110 (1999).
16. McFee, A. F., Sayer, A. M., Salomaa, S., Lindholm, C. and Littlefield, L. G. Methods for Improving the Yield and Quality of Metaphase Preparations for FISH Probing of Human Lymphocyte Chromosomes. Environ. Mol. Mutagen. 29, 98-104 (1997).
17. O'Neill, J. P., McGinniss, M. J., Berman, J. K., Sullivan, L. M., Nicklas, J. A. and Albertini, R. J. Refinement of a T-lymphocyte Cloning Assay to Quantify the in vivo Thioguanine Resistant Mutant Frequency in Human Somatic Cells. Mutagenesis 2, 87-94 (1987).
18. Stovall, M., Smith, S. A. and Rosenstein, M. Tissue Doses from Radiotherapy of Cancer of the Uterine Cervix. Med. Phys. 16, 726-733 (1989).
19. Tucker, J. D., Morgan, W. F., Awa, A. A., Bauchinger, M., Blakey, D., Cornforth, M. N., Littlefield, L. G., Natarajan, A. T. and Shasserre, C. A Proposed System for Scoring Structural Aberrations Detected by Chromosome Painting. Cytogenet. Cell Genet. 68, 211-221 (1995).
20. Lloyd, D. C., Purrott, R. J., Dolphin, G. W. and Edwards, A. A. Chromosome Aberrations Induced in Human Lymphocytes by Neutron Irradiation. Int. J. Radiat. Biol. 29(2), 169-182 (1976).
21. Straume, T. and Bender, M. A. Issues in Cytogenetic Biological Dosimetry: Emphasis on Radiation Environments in Space. Radiat. Res. 148, S60-S70 (1997).
22. Buckton, K. E. Identification with G and R Banding of the Position of Breakage Points Induced in Human Lymphocytes by in vitro X-radiation. Int. J. Radiat. Biol. 29, 475-511 (1976).
23. Ohtaki, K., Shiumba, H., Awa, A. A. and Sofuni, T. Comparison of Type and Frequency of Chromosome Aberrations by Conventional and G-staining Methods in Hiroshima Atomic Bomb Survivors. J. Radiat. Res. 23, 441-449 (1982).
24. Lindholm, C., Tekkel, M., Veidebaum, T., Ilus, T. and Salomaa, S. Persistence of Translocations after Accidental Exposure to Ionizing Radiation. Int. J. Radiat. Biol. 75, 565-571 (1998).